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    Ctla4 cytotoxic T-lymphocyte-associated protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 12477, updated on 25-May-2017
    Official Symbol
    Ctla4provided by MGI
    Official Full Name
    cytotoxic T-lymphocyte-associated protein 4provided by MGI
    Primary source
    MGI:MGI:88556
    See related
    Ensembl:ENSMUSG00000026011 Vega:OTTMUSG00000002278
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cd152; Ly-56; Ctla-4
    Summary
    This gene is a member of the immunoglobulin superfamily, and encodes a protein that functions as a negative regulator of T-cell responses. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2013]
    Orthologs
    Location:
    1 C2; 1 30.58 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (60909025..60915832)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (60965869..60972674)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 38137 Neighboring gene predicted gene, 39650 Neighboring gene ribosomal protein L18, pseudogene 1 Neighboring gene predicted gene, 34649 Neighboring gene dynein light chain LC8-type 1 pseudogene

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Autoimmune thyroid disease, organism-specific biosystem (from KEGG)
      Autoimmune thyroid disease, organism-specific biosystemThe classification of autoimmune throid disease (AITD) includes Hashimoto's thyroiditis (HT) or chronic autoimmune thyroiditis and its variants, Graves' disease (GD) and autoimmune atrophic thyroidi...
    • Autoimmune thyroid disease, conserved biosystem (from KEGG)
      Autoimmune thyroid disease, conserved biosystemThe classification of autoimmune throid disease (AITD) includes Hashimoto's thyroiditis (HT) or chronic autoimmune thyroiditis and its variants, Graves' disease (GD) and autoimmune atrophic thyroidi...
    • CTLA4 inhibitory signaling, organism-specific biosystem (from REACTOME)
      CTLA4 inhibitory signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Costimulation by the CD28 family, organism-specific biosystem (from REACTOME)
      Costimulation by the CD28 family, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Rheumatoid arthritis, organism-specific biosystem (from KEGG)
      Rheumatoid arthritis, organism-specific biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
    • Rheumatoid arthritis, conserved biosystem (from KEGG)
      Rheumatoid arthritis, conserved biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
    • T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
      T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • T cell receptor signaling pathway, conserved biosystem (from KEGG)
      T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
      XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    B cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    immune response IEA
    Inferred from Electronic Annotation
    more info
     
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of immune response ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of regulatory T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    clathrin-coated endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    protein complex involved in cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Preferred Names
    cytotoxic T-lymphocyte protein 4
    Names
    CD152 antigen
    cytotoxic T-lymphocyte-associated antigen 4

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001281976.1NP_001268905.1  cytotoxic T-lymphocyte protein 4 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001268905.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks the penultimate coding exon, which results in a frame-shift and early translation termination compared to variant 1. The resulting shorter isoform (2, also known as sCTLA-4) with a distinct C-terminus, lacks the transmembrane domain and is secreted (PMIDs: 10831323, 23400950).
      Source sequence(s)
      AI323635, AK138891, AL663047
      Consensus CDS
      CCDS69893.1
      UniProtKB/TrEMBL
      Q5SSM0
      Related
      ENSMUSP00000095327.3, OTTMUSP00000002172, ENSMUST00000097720.3, OTTMUST00000004536
      Conserved Domains (2) summary
      cd05721
      Location:39152
      IgV_CTLA-4; Immunoglobulin (Ig) domain of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)
      smart00410
      Location:43132
      IG_like; Immunoglobulin like
    2. NM_009843.4NP_033973.2  cytotoxic T-lymphocyte protein 4 isoform 1 precursor

      See identical proteins and their annotated locations for NP_033973.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer membrane-bound isoform (1).
      Source sequence(s)
      AI323635, AK138891, AL663047
      Consensus CDS
      CCDS14993.1
      UniProtKB/Swiss-Prot
      P09793
      UniProtKB/TrEMBL
      Q6GTR6
      Related
      ENSMUSP00000027164.2, OTTMUSP00000002168, ENSMUST00000027164.8, OTTMUST00000004524
      Conserved Domains (2) summary
      cd05721
      Location:39152
      IgV_CTLA-4; Immunoglobulin (Ig) domain of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)
      smart00410
      Location:43132
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      60909025..60915832
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 PATCHES

    Genomic

    1. NW_006763128.1 Reference GRCm38.p4 PATCHES

      Range
      240707..247494
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 NOD/MrkTac

    Genomic

    1. NT_187019.1 Reference GRCm38.p4 NOD/MrkTac

      Range
      279415..286202
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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