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    EDN1 endothelin 1 [ Homo sapiens (human) ]

    Gene ID: 1906, updated on 25-Jun-2017
    Official Symbol
    EDN1provided by HGNC
    Official Full Name
    endothelin 1provided by HGNC
    Primary source
    HGNC:HGNC:3176
    See related
    Ensembl:ENSG00000078401 MIM:131240; Vega:OTTHUMG00000014266
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ET1; QME; PPET1; ARCND3; HDLCQ7
    Summary
    This gene encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin/sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
    Orthologs
    Location:
    6p24.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 6 NC_000006.12 (12256464..12297194)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (12290529..12297427)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928253 Neighboring gene human immunodeficiency virus type I enhancer binding protein 1 Neighboring gene SUMO2 pseudogene 12 Neighboring gene uncharacterized LOC107986536

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Auriculocondylar syndrome 3
    MedGen: C3810332 OMIM: 615706 GeneReviews: Not available
    Compare labs
    Question mark ears, isolated
    MedGen: C2748545 OMIM: 612798 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    Genome-wide association study on plasma levels of midregional-proadrenomedullin and C-terminal-pro-endothelin-1.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 stimulates the secretion of endothelin-1, as well as TNF-alpha, from human cells in a concentration-dependent manner PubMed
    Nef nef The activation of extracellular signal-regulated kinase (ERK) by endothelin-1 (ET-1) is inhibited by HIV-1 Nef in human astrocytes; a similar inhibitory action of Nef on ERK activation was observed after direct stimulation of G proteins PubMed
    Tat tat HIV-1 Tat-linked intracellular third loop of the endothelin-1 type B receptor markedly enhances the endothelin-1 activation of ERK in the bone morphogenetic protein-2 receptor human pulmonary artery smooth muscle cells PubMed
    tat In HIV-1 Tat-expressing and HIV-infected astrocytes, endothelin-1 (ET-1) is significantly elevated through NF-kappaB (NF-kappaB)-responsive sites in the ET-1 promoter PubMed
    matrix gag HIV-1 MA-induced capillary-like structure formation is partially mediated by the ET-1/ETB receptor axis in human primary lymph node-derived lymphatic endothelial cells PubMed
    gag Exposure of human primary lymph node-derived lymphatic endothelial cells with HIV-1 MA induces release of ET-1 PubMed
    gag Treatment of human stellate cells with HIV-1 MA upregulates the expression of CXCR2, syndecan-2, collagen-I, alpha-SMA, vimentin, and endothelin-1 PubMed

    Go to the HIV-1, Human Interaction Database

    • AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystem (from KEGG)
      AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystemAdvanced glycation end products (AGEs) are a complex group of compounds produced through the non-enzymatic glycation and oxidation of proteins, lipids and nucleic acids, primarily due to aging and un...
    • AGE-RAGE signaling pathway in diabetic complications, conserved biosystem (from KEGG)
      AGE-RAGE signaling pathway in diabetic complications, conserved biosystemAdvanced glycation end products (AGEs) are a complex group of compounds produced through the non-enzymatic glycation and oxidation of proteins, lipids and nucleic acids, primarily due to aging and un...
    • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
      Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
    • EGFR-dependent Endothelin signaling events, organism-specific biosystem (from Pathway Interaction Database)
      EGFR-dependent Endothelin signaling events, organism-specific biosystem
      EGFR-dependent Endothelin signaling events
    • Endothelin Pathways, organism-specific biosystem (from WikiPathways)
      Endothelin Pathways, organism-specific biosystemEndothelin-1 is a bicyclic 21 amino acid peptide, produced primarily in the endothelium. It is a potent stimulus of long-lasting and persistent vasoconstriction. It also has a role as a stimulus of i...
    • Endothelins, organism-specific biosystem (from Pathway Interaction Database)
      Endothelins, organism-specific biosystem
      Endothelins
    • Fluid shear stress and atherosclerosis, organism-specific biosystem (from KEGG)
      Fluid shear stress and atherosclerosis, organism-specific biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
    • Fluid shear stress and atherosclerosis, conserved biosystem (from KEGG)
      Fluid shear stress and atherosclerosis, conserved biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
    • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
      Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
    • HIF-1 signaling pathway, organism-specific biosystem (from KEGG)
      HIF-1 signaling pathway, organism-specific biosystemHypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. It consists of two subunits: an inducibly-expressed HIF-1alpha subunit and a c...
    • HIF-1-alpha transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      HIF-1-alpha transcription factor network, organism-specific biosystem
      HIF-1-alpha transcription factor network
    • Lung fibrosis, organism-specific biosystem (from WikiPathways)
      Lung fibrosis, organism-specific biosystemLung fibrosis pathway linked to events (molecular initiating event, key events and associative events) in a putative Adverse Outcome Pathway for lung fibrosis.
    • Melanogenesis, organism-specific biosystem (from KEGG)
      Melanogenesis, organism-specific biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
    • Melanogenesis, conserved biosystem (from KEGG)
      Melanogenesis, conserved biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
    • Melatonin metabolism and effects, organism-specific biosystem (from WikiPathways)
      Melatonin metabolism and effects, organism-specific biosystemMelatonin is an important regulator of circadian rythmus and influences also insulin secretion, immune function, retinal function and neuroprotection. The synthesis starts with the amino acid tryptop...
    • MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem (from WikiPathways)
      MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystemThis pathway shows the role of microRNAs in the process of cardiac hypertrophy. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted interactions are shown in red dashed lin...
    • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
      Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
    • Photodynamic therapy-induced HIF-1 survival signaling, organism-specific biosystem (from WikiPathways)
      Photodynamic therapy-induced HIF-1 survival signaling, organism-specific biosystemPhotodynamic therapy may induce a hypoxic survival response mediated by HIF-1.
    • Physiological and Pathological Hypertrophy of the Heart, organism-specific biosystem (from WikiPathways)
      Physiological and Pathological Hypertrophy of the Heart, organism-specific biosystemPathways in physiological and pathological hypertrophy of the heart. Largely based on the article from Wang Y; ''Signal transduction in cardiac hypertrophy--dissecting compensatory versus pathologica...
    • Prostaglandin Synthesis and Regulation, organism-specific biosystem (from WikiPathways)
      Prostaglandin Synthesis and Regulation, organism-specific biosystemA prostaglandin is any member of a group of lipid compounds that are derived enzymatically from fatty acids and have important functions in the animal body. Every prostaglandin contains 20 carbon ato...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • TNF signaling pathway, organism-specific biosystem (from KEGG)
      TNF signaling pathway, organism-specific biosystemTumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF...
    • TNF signaling pathway, conserved biosystem (from KEGG)
      TNF signaling pathway, conserved biosystemTumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cytokine activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endothelin A receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endothelin B receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endothelin B receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    hormone activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    artery smooth muscle contraction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    artery smooth muscle contraction TAS
    Traceable Author Statement
    more info
    PubMed 
    body fluid secretion IEA
    Inferred from Electronic Annotation
    more info
     
    branching involved in blood vessel morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    calcium-mediated signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cartilage development IEA
    Inferred from Electronic Annotation
    more info
     
    cell growth IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to calcium ion IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to fatty acid IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to glucocorticoid stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to interferon-gamma IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to interleukin-1 IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to mineralocorticoid stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to peptide hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to transforming growth factor beta stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to tumor necrosis factor IEA
    Inferred from Electronic Annotation
    more info
     
    dorsal/ventral pattern formation IEA
    Inferred from Electronic Annotation
    more info
     
    epithelial fluid transport IEA
    Inferred from Electronic Annotation
    more info
     
    glucose transport IEA
    Inferred from Electronic Annotation
    more info
     
    heart development IEA
    Inferred from Electronic Annotation
    more info
     
    histamine secretion IEA
    Inferred from Electronic Annotation
    more info
     
    in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    inositol phosphate-mediated signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    leukocyte activation TAS
    Traceable Author Statement
    more info
    PubMed 
    maternal process involved in parturition IEA
    Inferred from Electronic Annotation
    more info
     
    membrane depolarization IEA
    Inferred from Electronic Annotation
    more info
     
    middle ear morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organism aging IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of blood coagulation TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of cAMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cellular protein metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of hormone secretion IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of nitric-oxide synthase biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of smooth muscle cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neural crest cell development IEA
    Inferred from Electronic Annotation
    more info
     
    NOT neutrophil chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nitric oxide transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptide hormone secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylinositol 3-kinase signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phospholipase D-activating G-protein coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of JUN kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cardiac muscle hypertrophy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell growth involved in cardiac muscle cell development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell growth involved in cardiac muscle cell development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell size IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of chemokine-mediated signaling pathway IC
    Inferred by Curator
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of endothelial cell migration TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of heart rate IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of hormone secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of mitotic nuclear division IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of neutrophil chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of nitric oxide biosynthetic process TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of odontogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of prostaglandin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of prostaglandin-endoperoxide synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of receptor biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of renal sodium excretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of sarcomere organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of sequence-specific DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of smooth muscle cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of urine volume IEA
    Inferred from Electronic Annotation
    more info
     
    prostaglandin biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase C deactivation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase C-activating G-protein coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of pH IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of sensory perception of pain IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of systemic arterial blood pressure by endothelin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
     
    respiratory gaseous exchange IEA
    Inferred from Electronic Annotation
    more info
     
    response to activity IEA
    Inferred from Electronic Annotation
    more info
     
    response to amino acid IEA
    Inferred from Electronic Annotation
    more info
     
    response to dexamethasone IEA
    Inferred from Electronic Annotation
    more info
     
    response to leptin IEA
    Inferred from Electronic Annotation
    more info
     
    response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    response to muscle stretch IEA
    Inferred from Electronic Annotation
    more info
     
    response to nicotine IEA
    Inferred from Electronic Annotation
    more info
     
    response to ozone IEA
    Inferred from Electronic Annotation
    more info
     
    response to prostaglandin F IEA
    Inferred from Electronic Annotation
    more info
     
    response to salt IEA
    Inferred from Electronic Annotation
    more info
     
    response to testosterone IEA
    Inferred from Electronic Annotation
    more info
     
    rhythmic excitation IEA
    Inferred from Electronic Annotation
    more info
     
    sensory perception of pain IEA
    Inferred from Electronic Annotation
    more info
     
    superoxide anion generation IEA
    Inferred from Electronic Annotation
    more info
     
    vasoconstriction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    vein smooth muscle contraction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    Weibel-Palade body IEA
    Inferred from Electronic Annotation
    more info
     
    basal part of cell IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    rough endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
     
    transport vesicle TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    endothelin-1
    Names
    preproendothelin-1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016196.1 RefSeqGene

      Range
      5001..11899
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001168319.1NP_001161791.1  endothelin-1 isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_001161791.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
      Source sequence(s)
      AL548191, AW044634, BQ009676, BX439515, S56805, Z98050
      UniProtKB/Swiss-Prot
      P05305
      Conserved Domains (3) summary
      PHA02659
      Location:472
      PHA02659; endothelin precursor; Provisional
      smart00272
      Location:107128
      END; Endothelin
      pfam00322
      Location:4876
      Endothelin; Endothelin family
    2. NM_001955.4NP_001946.3  endothelin-1 isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_001946.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL548191, AW044634, BQ009676, S56805, Z98050
      Consensus CDS
      CCDS4522.1
      UniProtKB/Swiss-Prot
      P05305
      UniProtKB/TrEMBL
      Q6FH53
      Related
      ENSP00000368683.5, OTTHUMP00000016038, ENST00000379375.5, OTTHUMT00000039872
      Conserved Domains (2) summary
      smart00272
      Location:108129
      END; Endothelin
      pfam00322
      Location:4977
      Endothelin; Endothelin family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p7 Primary Assembly

      Range
      12256464..12297194
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011514331.2XP_011512633.1  endothelin-1 isoform X1

      See identical proteins and their annotated locations for XP_011512633.1

      UniProtKB/Swiss-Prot
      P05305
      UniProtKB/TrEMBL
      Q6FH53
      Conserved Domains (2) summary
      smart00272
      Location:108129
      END; Endothelin
      pfam00322
      Location:4977
      Endothelin; Endothelin family
    2. XM_011514332.2XP_011512634.1  endothelin-1 isoform X2

      See identical proteins and their annotated locations for XP_011512634.1

      Conserved Domains (3) summary
      PHA02659
      Location:472
      PHA02659; endothelin precursor; Provisional
      smart00272
      Location:107128
      END; Endothelin
      pfam00322
      Location:4876
      Endothelin; Endothelin family
    3. XM_011514330.2XP_011512632.1  endothelin-1 isoform X1

      See identical proteins and their annotated locations for XP_011512632.1

      UniProtKB/Swiss-Prot
      P05305
      UniProtKB/TrEMBL
      Q6FH53
      Conserved Domains (2) summary
      smart00272
      Location:108129
      END; Endothelin
      pfam00322
      Location:4977
      Endothelin; Endothelin family
    4. XM_017010331.1XP_016865820.1  endothelin-1 isoform X1

      UniProtKB/Swiss-Prot
      P05305
      UniProtKB/TrEMBL
      Q6FH53
      Conserved Domains (2) summary
      smart00272
      Location:108129
      END; Endothelin
      pfam00322
      Location:4977
      Endothelin; Endothelin family

    Alternate CHM1_1.1

    Genomic

    1. NC_018917.2 Alternate CHM1_1.1

      Range
      12292671..12299570
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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