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    ANK1 ankyrin 1 [ Homo sapiens (human) ]

    Gene ID: 286, updated on 31-Dec-2017
    Official Symbol
    ANK1provided by HGNC
    Official Full Name
    ankyrin 1provided by HGNC
    Primary source
    HGNC:HGNC:492
    See related
    Ensembl:ENSG00000029534 MIM:612641; Vega:OTTHUMG00000150281
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ANK; SPH1; SPH2
    Summary
    Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified. [provided by RefSeq, Dec 2008]
    Expression
    Biased expression in bone marrow (RPKM 23.4) and heart (RPKM 5.1) See more
    Orthologs
    Location:
    8p11.21
    Exon count:
    49
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 8 NC_000008.11 (41653225..41896762, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (41510744..41754280, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723729 Neighboring gene glycerol-3-phosphate acyltransferase 4 Neighboring gene microRNA 486-1 Neighboring gene microRNA 486-2 Neighboring gene NK6 homeobox 3 Neighboring gene uncharacterized LOC105379392 Neighboring gene RNA, 7SL, cytoplasmic 149, pseudogene Neighboring gene lysine acetyltransferase 6A Neighboring gene uncharacterized LOC105379393 Neighboring gene ribosomal protein L17 pseudogene 30

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Spherocytosis type 1
    MedGen: C2674218 OMIM: 182900 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations.
    NHGRI GWA Catalog
    Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways.
    NHGRI GWA Catalog
    Genome-wide association study of lung function decline in adults with and without asthma.
    NHGRI GWA Catalog
    Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
    NHGRI GWA Catalog
    Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Ankyrin binds to the N-terminal region (residues 132-241) of the CA domain of HIV-1 Gag. Ankyrin decreases expression of Gag in HIV-1-infected SupT1 cells PubMed

    Go to the HIV-1, Human Interaction Database

    • Asparagine N-linked glycosylation, organism-specific biosystem (from REACTOME)
      Asparagine N-linked glycosylation, organism-specific biosystemN-linked glycosylation is the most important form of post-translational modification for proteins synthesized and folded in the Endoplasmic Reticulum (Stanley et al. 2009). An early study in 1999 rev...
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • CHL1 interactions, organism-specific biosystem (from REACTOME)
      CHL1 interactions, organism-specific biosystemClose homolog of L1 (CHL1) is a member of the L1 family of cell adhesion molecules expressed by subpopulations of neurons and glia in the central and peripheral nervous system. CHL1 like L1 promotes ...
    • COPI-mediated anterograde transport, organism-specific biosystem (from REACTOME)
      COPI-mediated anterograde transport, organism-specific biosystemThe ERGIC (ER-to-Golgi intermediate compartment, also known as vesicular-tubular clusters, VTCs) is a stable, biochemically distinct compartment located adjacent to ER exit sites (Ben-Tekaya et al, 2...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • ER to Golgi Anterograde Transport, organism-specific biosystem (from REACTOME)
      ER to Golgi Anterograde Transport, organism-specific biosystemSecretory cargo destined to be secreted or to arrive at the plasma membrane (PM) leaves the ER via distinct exit sites. This cargo is destined for the Golgi apparatus for further processing.
    • Interaction between L1 and Ankyrins, organism-specific biosystem (from REACTOME)
      Interaction between L1 and Ankyrins, organism-specific biosystemAnkyrins are a family of adaptor proteins that couple membrane proteins such as voltage gated Na+ channels and the Na+/K+ anion exchanger to the spectrin actin cytoskeleton. Ankyrins are encoded by t...
    • L1CAM interactions, organism-specific biosystem (from REACTOME)
      L1CAM interactions, organism-specific biosystemThe L1 family of cell adhesion molecules (L1CAMs) are a subfamily of the immunoglobulin superfamily of transmembrane receptors, comprised of four structurally related proteins: L1, Close Homolog of L...
    • Membrane Trafficking, organism-specific biosystem (from REACTOME)
      Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Neurofascin interactions, organism-specific biosystem (from REACTOME)
      Neurofascin interactions, organism-specific biosystemNeurofascin is an L1 family immunoglobulin cell adhesion molecule involved in axon subcellular targeting and synapse formation during neural development. There are a range of different isoforms ident...
    • NrCAM interactions, organism-specific biosystem (from REACTOME)
      NrCAM interactions, organism-specific biosystemThe NgCAM-related cell adhesion molecule (NrCAM) is member of the L1 family involved in the eye development and node of Ranvier. Like all the other members of L1 family NrCAM also has the ability to...
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
      Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • Proteoglycans in cancer, conserved biosystem (from KEGG)
      Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • Transport to the Golgi and subsequent modification, organism-specific biosystem (from REACTOME)
      Transport to the Golgi and subsequent modification, organism-specific biosystemAt least two mechanisms of transport of proteins from the ER to the Golgi have been described. One is a general flow requiring no export signals (Wieland et al, 1987; Martinez-Menarguez et al, 1999)....
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    cytoskeletal adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoskeletal adaptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enzyme binding TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    spectrin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spectrin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    spectrin binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    structural constituent of cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    structural molecule activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    ER to Golgi vesicle-mediated transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ER to Golgi vesicle-mediated transport TAS
    Traceable Author Statement
    more info
     
    cytoskeleton organization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    exocytosis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    maintenance of epithelial cell apical/basal polarity TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of organelle organization IEA
    Inferred from Electronic Annotation
    more info
     
    protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    M band IEA
    Inferred from Electronic Annotation
    more info
     
    Z disc IEA
    Inferred from Electronic Annotation
    more info
     
    axolemma IEA
    Inferred from Electronic Annotation
    more info
     
    basolateral plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cytoskeleton NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    sarcolemma IEA
    Inferred from Electronic Annotation
    more info
     
    sarcoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    spectrin-associated cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    ankyrin-1
    Names
    ANK-1
    ankyrin 1, erythrocytic
    ankyrin-R
    erythrocyte ankyrin

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012820.1 RefSeqGene

      Range
      5001..248537
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000037.3NP_000028.3  ankyrin-1 isoform 3

      See identical proteins and their annotated locations for NP_000028.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an alternate segment in the 3' coding region, which includes a stop codon, compared to variant 1. The resulting isoform (3) has a distinct and one aa shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AB209418, AC113133, M28880, N63745, X16609
      Consensus CDS
      CCDS6121.1
      UniProtKB/Swiss-Prot
      P16157
      Related
      ENSP00000289734.7, OTTHUMP00000196861, ENST00000289734.11, OTTHUMT00000317298
      Conserved Domains (10) summary
      smart00218
      Location:9111015
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      smart00248
      Location:601630
      ANK; ankyrin repeats
      COG0666
      Location:341554
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:365490
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08805
      Location:14011484
      Death_ank1; Death domain of Ankyrin-1
      pfam00023
      Location:337367
      Ank; Ankyrin repeat
      pfam12796
      Location:639730
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:1465
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:720774
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:403434
      ANK; ANK repeat [structural motif]
    2. NM_001142445.1NP_001135917.1  ankyrin-1 isoform 10 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) lacks multiple 5' exons, but has an alternate 5' exon which includes an AUG start codon, compared to variant 1. The resulting isoform (10) has a much shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC113133, BC014467, N63745
      Consensus CDS
      CCDS55227.1
      UniProtKB/Swiss-Prot
      P16157
      Related
      ENSP00000430368.1, OTTHUMP00000225820, ENST00000522543.5, OTTHUMT00000377169
    3. NM_001142446.1NP_001135918.1  ankyrin-1 isoform 9

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) has an alternate upstream 5' exon, which includes an AUG start codon, and has an additional exon in the middle region, but lacks a segment in the 3' coding region, compared to variant 1. The reading frame is not affected and the resulting isoform (9) is the longest, which has a distinct N-terminus and an internal additional segment as well as lacks a segment in the C-terminal region, compared to isoform 1.
      Source sequence(s)
      AB209418, AC027702, AC113133, N63745, X16609
      Consensus CDS
      CCDS47849.1
      UniProtKB/Swiss-Prot
      P16157
      Related
      ENSP00000265709.8, OTTHUMP00000225822, ENST00000265709.12, OTTHUMT00000377171
      Conserved Domains (10) summary
      smart00218
      Location:9521056
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      smart00248
      Location:634663
      ANK; ankyrin repeats
      COG0666
      Location:374587
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:398523
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08805
      Location:14421525
      Death_ank1; Death domain of Ankyrin-1
      pfam00023
      Location:370400
      Ank; Ankyrin repeat
      pfam12796
      Location:672763
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:4798
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:753807
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:436467
      ANK; ANK repeat [structural motif]
    4. NM_020475.2NP_065208.2  ankyrin-1 isoform 4

      See identical proteins and their annotated locations for NP_065208.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an in-frame segment in the 3' coding region, compared to variant 1. The resulting isoform (4) is therefore shorter than isoform 1.
      Source sequence(s)
      AA404587, AB209418, AC113133, M28880, N63745, X16609
      UniProtKB/Swiss-Prot
      P16157
      Conserved Domains (10) summary
      smart00218
      Location:9111015
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      smart00248
      Location:601630
      ANK; ankyrin repeats
      COG0666
      Location:341554
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:365490
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08805
      Location:14011484
      Death_ank1; Death domain of Ankyrin-1
      pfam00023
      Location:337367
      Ank; Ankyrin repeat
      pfam12796
      Location:639730
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:1465
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:720774
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:403434
      ANK; ANK repeat [structural motif]
    5. NM_020476.2NP_065209.2  ankyrin-1 isoform 1

      See identical proteins and their annotated locations for NP_065209.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1, also referred to as isoform 2.1.
      Source sequence(s)
      AB209418, AC113133, M28880, N63745, X16609
      Consensus CDS
      CCDS6119.1
      UniProtKB/Swiss-Prot
      P16157
      Related
      ENSP00000339620.4, OTTHUMP00000196860, ENST00000347528.8, OTTHUMT00000317297
      Conserved Domains (10) summary
      smart00218
      Location:9111015
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      smart00248
      Location:601630
      ANK; ankyrin repeats
      COG0666
      Location:341554
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:365490
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08805
      Location:14011484
      Death_ank1; Death domain of Ankyrin-1
      pfam00023
      Location:337367
      Ank; Ankyrin repeat
      pfam12796
      Location:639730
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:1465
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:720774
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:403434
      ANK; ANK repeat [structural motif]
    6. NM_020477.2NP_065210.2  ankyrin-1 isoform 2

      See identical proteins and their annotated locations for NP_065210.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame segment near to the 3' coding region, compared to variant 1. The resulting isoform (2, also referred to as isoform 2.2) is therefore shorter than isoform 1.
      Source sequence(s)
      AB209418, AC113133, AK126647, M28880, N63745, X16609
      UniProtKB/Swiss-Prot
      P16157
      UniProtKB/TrEMBL
      B3KX39
      Conserved Domains (10) summary
      smart00218
      Location:9111015
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      smart00248
      Location:601630
      ANK; ankyrin repeats
      COG0666
      Location:341554
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:365490
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08805
      Location:14011484
      Death_ank1; Death domain of Ankyrin-1
      pfam00023
      Location:337367
      Ank; Ankyrin repeat
      pfam12796
      Location:639730
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:1465
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:720774
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:403434
      ANK; ANK repeat [structural motif]
    7. NM_020478.4NP_065211.2  ankyrin-1 isoform 5 precursor

      See identical proteins and their annotated locations for NP_065211.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks multiple 5' exons, but has an alternate 5' exon, which includes an AUG start codon, and it also has an alternate segment in the 3' coding region, which includes a stop codon, compared to variant 1. The resulting isoform (5, also referred to as Ank 1.5 and sAnk1) has a much shorter and distinct N-terminus and also has a distinct C-terminus, compared to isoform 1. This small isoform binds to the C-terminus of obscurin, a giant protein surrounding the contractile apparatus in striated muscle, and the binding may be essential for the proper alignment of the network sarcoplasmic reticulum.
      Source sequence(s)
      AC113133, AK223578, BC014467, N63745
      Consensus CDS
      CCDS6122.1
      UniProtKB/Swiss-Prot
      P16157
      Related
      ENSP00000319123.8, OTTHUMP00000196862, ENST00000314214.12, OTTHUMT00000317299
    8. NM_020480.4NP_065213.2  ankyrin-1 isoform 7 precursor

      See identical proteins and their annotated locations for NP_065213.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks multiple 5' exons and an in-frame coding exon in the 3' region, but has an alternate 5' exon which includes an AUG start codon, compared to variant 1. The resulting isoform (7) has a much shorter and distinct N-terminus, and lacks a segment in the C-terminal region, compared to isoform 1.
      Source sequence(s)
      AC113133, BC014467, BC117121, N63745
      Consensus CDS
      CCDS6120.1
      UniProtKB/Swiss-Prot
      P16157
      Related
      ENSP00000297744.5, OTTHUMP00000196863, ENST00000348036.8, OTTHUMT00000317300

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p7 Primary Assembly

      Range
      41653225..41896762 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005273476.4XP_005273533.1  ankyrin-1 isoform X12

      Conserved Domains (10) summary
      smart00218
      Location:9521056
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      smart00248
      Location:634663
      ANK; ankyrin repeats
      COG0666
      Location:374587
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:398523
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08805
      Location:14421525
      Death_ank1; Death domain of Ankyrin-1
      pfam00023
      Location:370400
      Ank; Ankyrin repeat
      pfam12796
      Location:672763
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:4798
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:753807
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:436467
      ANK; ANK repeat [structural motif]
    2. XM_017013324.1XP_016868813.1  ankyrin-1 isoform X11

    3. XM_017013329.1XP_016868818.1  ankyrin-1 isoform X21

    4. XM_011544505.2XP_011542807.1  ankyrin-1 isoform X23

      Conserved Domains (10) summary
      smart00218
      Location:9441048
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      smart00248
      Location:634663
      ANK; ankyrin repeats
      COG0666
      Location:374587
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:398523
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08805
      Location:14341517
      Death_ank1; Death domain of Ankyrin-1
      pfam00023
      Location:370400
      Ank; Ankyrin repeat
      pfam12796
      Location:672763
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:4798
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:753807
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:436467
      ANK; ANK repeat [structural motif]
    5. XM_011544504.2XP_011542806.1  ankyrin-1 isoform X22

      Conserved Domains (10) summary
      smart00218
      Location:9441048
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      smart00248
      Location:634663
      ANK; ankyrin repeats
      COG0666
      Location:374587
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:398523
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08805
      Location:14341517
      Death_ank1; Death domain of Ankyrin-1
      pfam00023
      Location:370400
      Ank; Ankyrin repeat
      pfam12796
      Location:672763
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:4798
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:753807
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:436467
      ANK; ANK repeat [structural motif]
    6. XM_011544502.2XP_011542804.1  ankyrin-1 isoform X17

      Conserved Domains (10) summary
      smart00218
      Location:9441048
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      smart00248
      Location:634663
      ANK; ankyrin repeats
      COG0666
      Location:374587
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:398523
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08805
      Location:14341517
      Death_ank1; Death domain of Ankyrin-1
      pfam00023
      Location:370400
      Ank; Ankyrin repeat
      pfam12796
      Location:672763
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:4798
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:753807
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:436467
      ANK; ANK repeat [structural motif]
    7. XM_011544501.2XP_011542803.1  ankyrin-1 isoform X14

      Conserved Domains (10) summary
      smart00218
      Location:9441048
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      smart00248
      Location:634663
      ANK; ankyrin repeats
      COG0666
      Location:374587
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:398523
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08805
      Location:14341517
      Death_ank1; Death domain of Ankyrin-1
      pfam00023
      Location:370400
      Ank; Ankyrin repeat
      pfam12796
      Location:672763
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:4798
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:753807
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:436467
      ANK; ANK repeat [structural motif]
    8. XM_011544500.2XP_011542802.1  ankyrin-1 isoform X13

      Conserved Domains (10) summary
      smart00218
      Location:9441048
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      smart00248
      Location:634663
      ANK; ankyrin repeats
      COG0666
      Location:374587
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:398523
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08805
      Location:14341517
      Death_ank1; Death domain of Ankyrin-1
      pfam00023
      Location:370400
      Ank; Ankyrin repeat
      pfam12796
      Location:672763
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:4798
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:753807
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:436467
      ANK; ANK repeat [structural motif]
    9. XM_017013322.1XP_016868811.1  ankyrin-1 isoform X9

    10. XM_017013320.1XP_016868809.1  ankyrin-1 isoform X6

    11. XM_011544496.2XP_011542798.1  ankyrin-1 isoform X7

      Conserved Domains (9) summary
      smart00218
      Location:9841088
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      smart00248
      Location:666695
      ANK; ankyrin repeats
      COG0666
      Location:406619
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:430555
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08805
      Location:14741557
      Death_ank1; Death domain of Ankyrin-1
      pfam00023
      Location:402432
      Ank; Ankyrin repeat
      pfam12796
      Location:704795
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:785839
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:468499
      ANK; ANK repeat [structural motif]
    12. XM_011544490.2XP_011542792.1  ankyrin-1 isoform X1

      Conserved Domains (9) summary
      smart00218
      Location:9841088
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      smart00248
      Location:666695
      ANK; ankyrin repeats
      COG0666
      Location:406619
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:430555
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08805
      Location:14741557
      Death_ank1; Death domain of Ankyrin-1
      pfam00023
      Location:402432
      Ank; Ankyrin repeat
      pfam12796
      Location:704795
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:785839
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:468499
      ANK; ANK repeat [structural motif]
    13. XM_017013319.1XP_016868808.1  ankyrin-1 isoform X3

    14. XM_017013328.1XP_016868817.1  ankyrin-1 isoform X19

    15. XM_017013327.1XP_016868816.1  ankyrin-1 isoform X18

    16. XM_011544494.2XP_011542796.1  ankyrin-1 isoform X4

      Conserved Domains (9) summary
      smart00218
      Location:9841088
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      smart00248
      Location:666695
      ANK; ankyrin repeats
      COG0666
      Location:406619
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:430555
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08805
      Location:14741557
      Death_ank1; Death domain of Ankyrin-1
      pfam00023
      Location:402432
      Ank; Ankyrin repeat
      pfam12796
      Location:704795
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:785839
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:468499
      ANK; ANK repeat [structural motif]
    17. XM_011544491.2XP_011542793.1  ankyrin-1 isoform X2

      Conserved Domains (9) summary
      smart00218
      Location:9841088
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      smart00248
      Location:666695
      ANK; ankyrin repeats
      COG0666
      Location:406619
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:430555
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08805
      Location:14741557
      Death_ank1; Death domain of Ankyrin-1
      pfam00023
      Location:402432
      Ank; Ankyrin repeat
      pfam12796
      Location:704795
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:785839
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:468499
      ANK; ANK repeat [structural motif]
    18. XM_011544495.2XP_011542797.1  ankyrin-1 isoform X5

      Conserved Domains (9) summary
      smart00218
      Location:9841088
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      smart00248
      Location:666695
      ANK; ankyrin repeats
      COG0666
      Location:406619
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:430555
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08805
      Location:14741557
      Death_ank1; Death domain of Ankyrin-1
      pfam00023
      Location:402432
      Ank; Ankyrin repeat
      pfam12796
      Location:704795
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:785839
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:468499
      ANK; ANK repeat [structural motif]
    19. XM_011544503.2XP_011542805.1  ankyrin-1 isoform X20

      Conserved Domains (9) summary
      smart00218
      Location:9841088
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      smart00248
      Location:666695
      ANK; ankyrin repeats
      COG0666
      Location:406619
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:430555
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd08805
      Location:14741557
      Death_ank1; Death domain of Ankyrin-1
      pfam00023
      Location:402432
      Ank; Ankyrin repeat
      pfam12796
      Location:704795
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:785839
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:468499
      ANK; ANK repeat [structural motif]
    20. XM_017013323.1XP_016868812.1  ankyrin-1 isoform X10

    21. XM_017013321.1XP_016868810.1  ankyrin-1 isoform X8

    22. XM_017013325.1XP_016868814.1  ankyrin-1 isoform X15

    23. XM_017013326.1XP_016868815.1  ankyrin-1 isoform X16

    Alternate CHM1_1.1

    Genomic

    1. NC_018919.2 Alternate CHM1_1.1

      Range
      41558937..41802421 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_020479.2: Suppressed sequence

      Description
      NM_020479.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    2. NM_020481.2: Suppressed sequence

      Description
      NM_020481.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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