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    NRP1 neuropilin 1 [ Homo sapiens (human) ]

    Gene ID: 8829, updated on 11-Apr-2018
    Official Symbol
    NRP1provided by HGNC
    Official Full Name
    neuropilin 1provided by HGNC
    Primary source
    HGNC:HGNC:8004
    See related
    Ensembl:ENSG00000099250 MIM:602069; Vega:OTTHUMG00000019343
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NP1; NRP; BDCA4; CD304; VEGF165R
    Summary
    This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
    Expression
    Broad expression in placenta (RPKM 53.3), fat (RPKM 49.6) and 24 other tissues See more
    Orthologs
    Location:
    10p11.22
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (33177491..33334905, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (33466419..33623833, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ITGB1 divergent transcript Neighboring gene uncharacterized LOC101929447 Neighboring gene ribosomal protein L7a pseudogene 53 Neighboring gene RNA, 7SL, cytoplasmic 398, pseudogene Neighboring gene uncharacterized LOC105376489 Neighboring gene uncharacterized LOC105376490

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    DOCK4 and CEACAM21 as novel schizophrenia candidate genes in the Jewish population.
    NHGRI GWA Catalog
    Genome-wide association study identifies loci on 12q24 and 13q32 associated with tetralogy of Fallot.
    NHGRI GWA Catalog
    Genome-wide meta-analysis identifies new susceptibility loci for migraine.
    NHGRI GWA Catalog

    Replication interactions

    Interaction Pubs
    Knockdown of neuropilin 1 (NRP1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 Nef upregulates VEGFR2 and its co-receptor neuropilin-1 and downregulates the expression of semaphorin 3a in podocytes PubMed

    Go to the HIV-1, Human Interaction Database

    • Axon guidance, organism-specific biosystem (from KEGG)
      Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, conserved biosystem (from KEGG)
      Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • CHL1 interactions, organism-specific biosystem (from REACTOME)
      CHL1 interactions, organism-specific biosystemClose homolog of L1 (CHL1) is a member of the L1 family of cell adhesion molecules expressed by subpopulations of neurons and glia in the central and peripheral nervous system. CHL1 like L1 promotes ...
    • CRMPs in Sema3A signaling, organism-specific biosystem (from REACTOME)
      CRMPs in Sema3A signaling, organism-specific biosystemCRMPs are a small family of plexinA-interacting cytosolic phosphoproteins identified as mediators of Sema3A signaling and neuronal differentiation. After Sema3A activation Plexin-A bound CRMP's under...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • L1CAM interactions, organism-specific biosystem (from REACTOME)
      L1CAM interactions, organism-specific biosystemThe L1 family of cell adhesion molecules (L1CAMs) are a subfamily of the immunoglobulin superfamily of transmembrane receptors, comprised of four structurally related proteins: L1, Close Homolog of L...
    • Neurophilin interactions with VEGF and VEGFR, organism-specific biosystem (from REACTOME)
      Neurophilin interactions with VEGF and VEGFR, organism-specific biosystemThe plasma membrane-associated Neuropilin receptors NRP-1 and -2 bind some of the VEGF proteins and associate with VEGF receptor proteins. NRP-1 binds VEGF-A165, -B, and PLGF-2; NRP-2 also binds VEGF...
    • SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion, organism-specific biosystem (from REACTOME)
      SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion, organism-specific biosystemSema3A, a prototypical semaphorin, acts as a chemorepellent or a chemoattractant for axons by activating a receptor complex comprising neuropilin-1 as the ligand-binding subunit and plexin-A1 as the ...
    • Sema3A PAK dependent Axon repulsion, organism-specific biosystem (from REACTOME)
      Sema3A PAK dependent Axon repulsion, organism-specific biosystemActivated Rac1 bound to plexin-A might modulate actin dynamics through the sequential phosphorylation and activation of PAK, LIMK1 and cofilin.
    • Semaphorin interactions, organism-specific biosystem (from REACTOME)
      Semaphorin interactions, organism-specific biosystemSemaphorins are a large family of cell surface and secreted guidance molecules divided into eight classes on the basis of their structures. They all have an N-terminal conserved sema domain. Semaphor...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signal transduction by L1, organism-specific biosystem (from REACTOME)
      Signal transduction by L1, organism-specific biosystemBesides adhesive roles in cell cell interaction, L1 functions as a signal transducing receptor providing neurons with cues from their environment for axonal growth and guidance. L1 associates with be...
    • Signaling by VEGF, organism-specific biosystem (from REACTOME)
      Signaling by VEGF, organism-specific biosystemIn normal development vascular endothelial growth factors (VEGFs) are crucial regulators of vascular development during embryogenesis (vasculogenesis) and blood-vessel formation in the adult (angioge...
    • Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem
      Signaling events mediated by VEGFR1 and VEGFR2
    • VEGFR1 specific signals, organism-specific biosystem (from Pathway Interaction Database)
      VEGFR1 specific signals, organism-specific biosystem
      VEGFR1 specific signals
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • DKFZp781F1414, DKFZp686A03134

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTPase activator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    coreceptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    cytokine binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    growth factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    growth factor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    semaphorin receptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    vascular endothelial growth factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    vascular endothelial growth factor-activated receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    vascular endothelial growth factor-activated receptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    VEGF-activated neuropilin signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    VEGF-activated neuropilin signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    VEGF-activated neuropilin signaling pathway involved in axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    actin cytoskeleton reorganization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    angiogenesis involved in coronary vascular morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    animal organ morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    artery morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    axon extension involved in axon guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    axon guidance NAS
    Non-traceable Author Statement
    more info
    PubMed 
    axonal fasciculation IEA
    Inferred from Electronic Annotation
    more info
     
    axonogenesis involved in innervation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    basal dendrite arborization ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    basal dendrite development ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    branching involved in blood vessel morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    branchiomotor neuron axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    cell migration involved in sprouting angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular response to hepatocyte growth factor stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to vascular endothelial growth factor stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    commissural neuron axon guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    coronary artery morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    dichotomous subdivision of terminal units involved in salivary gland branching IEA
    Inferred from Electronic Annotation
    more info
     
    dorsal root ganglion morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    endothelial cell chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endothelial tip cell fate specification ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    facial nerve structural organization IEA
    Inferred from Electronic Annotation
    more info
     
    facioacoustic ganglion development IEA
    Inferred from Electronic Annotation
    more info
     
    gonadotrophin-releasing hormone neuronal migration to the hypothalamus IEA
    Inferred from Electronic Annotation
    more info
     
    hepatocyte growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    integrin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    motor neuron migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of axon extension involved in axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of extrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    nerve development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neural crest cell migration involved in autonomic nervous system development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuron migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuropilin signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    otic placode development IEA
    Inferred from Electronic Annotation
    more info
     
    outflow tract septum morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    platelet-derived growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of actin cytoskeleton reorganization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of axon extension involved in axon guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cell migration involved in sprouting angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cytokine activity TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of endothelial cell migration TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of endothelial cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of filopodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of focal adhesion assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of retinal ganglion cell axon guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of smooth muscle cell migration TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of stress fiber assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of substrate adhesion-dependent cell spreading IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein localization to early endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    regulation of Cdc42 protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of retinal ganglion cell axon guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of vesicle-mediated transport TAS
    Traceable Author Statement
    more info
    PubMed 
    renal artery morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    response to wounding IEA
    Inferred from Electronic Annotation
    more info
     
    retina vasculature morphogenesis in camera-type eye ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    retinal ganglion cell axon guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    semaphorin-plexin signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    semaphorin-plexin signaling pathway involved in axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    semaphorin-plexin signaling pathway involved in neuron projection guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    sensory neuron axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    sprouting angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    substrate adhesion-dependent cell spreading IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    substrate-dependent cell migration, cell extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sympathetic ganglion development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    sympathetic neuron projection extension ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    sympathetic neuron projection guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    toxin transport IEA
    Inferred from Electronic Annotation
    more info
     
    trigeminal ganglion development IEA
    Inferred from Electronic Annotation
    more info
     
    trigeminal nerve structural organization IEA
    Inferred from Electronic Annotation
    more info
     
    vascular endothelial growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vascular endothelial growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    ventral trunk neural crest cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    vestibulocochlear nerve structural organization IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic vesicle TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    early endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    extracellular space HDA PubMed 
    focal adhesion HDA PubMed 
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    growth cone IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neurofilament IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    receptor complex TAS
    Traceable Author Statement
    more info
    PubMed 
    semaphorin receptor complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    sorting endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Preferred Names
    neuropilin-1
    Names
    transmembrane receptor
    vascular endothelial cell growth factor 165 receptor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030328.1 RefSeqGene

      Range
      5001..162415
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001024628.2NP_001019799.1  neuropilin-1 isoform b precursor

      See identical proteins and their annotated locations for NP_001019799.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses a different splice site in the 3' end and contains a different segment for the 3' end of the coding region and the 3' UTR, compared to variant 1. The resulting protein (isoform b) has a shorter C-terminus when compared to isoform a. This variant has also been named S12NRP1 in PubMed ID: 11112349.
      Source sequence(s)
      AA973607, AL698999, BC007533, CR749333, DA702852
      Consensus CDS
      CCDS31180.1
      UniProtKB/Swiss-Prot
      O14786
      UniProtKB/TrEMBL
      Q68DN3
      Related
      ENSP00000363955.4, OTTHUMP00000020820, ENST00000374822.8, OTTHUMT00000051205
      Conserved Domains (2) summary
      cd00041
      Location:27140
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:277423
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    2. NM_001024629.2NP_001019800.1  neuropilin-1 isoform c precursor

      See identical proteins and their annotated locations for NP_001019800.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame coding region segment, uses a different splice site in the 3' end and contains a different segment for the 3' end of the coding region and the 3' UTR, compared to variant 1. The resulting protein (isoform c) has a shorter C-terminus when compared to isoform a.
      Source sequence(s)
      AA973607, AL698999, BC007737, CR749333, DA702852
      Consensus CDS
      CCDS31179.1
      UniProtKB/Swiss-Prot
      O14786
      UniProtKB/TrEMBL
      Q68DN3
      Related
      ENSP00000363954.5, OTTHUMP00000020821, ENST00000374821.9, OTTHUMT00000051206
      Conserved Domains (2) summary
      cd00041
      Location:27140
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:277423
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    3. NM_001244972.1NP_001231901.1  neuropilin-1 isoform d precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses two different splice sites in the coding region, compared to variant 1. The resulting protein (isoform d) is shorter when it is compared to isoform a.
      Source sequence(s)
      AB209641, AK292822, AL353600, BX648250
      UniProtKB/TrEMBL
      A8K9V7, Q59F20
      Conserved Domains (6) summary
      cd06263
      Location:643797
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      pfam11980
      Location:837914
      DUF3481; Domain of unknown function (DUF3481)
      smart00137
      Location:638798
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00231
      Location:274424
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:27140
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:277423
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    4. NM_001244973.1NP_001231902.1  neuropilin-1 isoform e precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses a different splice site in the coding region, compared to variant 1. The resulting protein (isoform e) is shorter when it is compared to isoform a.
      Source sequence(s)
      AB209641, AL121748, AL353600, BX648250
      UniProtKB/TrEMBL
      Q59F20
      Conserved Domains (6) summary
      cd06263
      Location:643796
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      pfam11980
      Location:836913
      DUF3481; Domain of unknown function (DUF3481)
      smart00137
      Location:638797
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00231
      Location:274424
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:27140
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:277423
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    5. NM_001330068.1NP_001316997.1  neuropilin-1 isoform f precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform f, which is shorter than isoform a.
      Source sequence(s)
      AF018956, AL121748, AL353600, AY249243, BU858030, BX648250
      Consensus CDS
      CCDS81448.1
      UniProtKB/Swiss-Prot
      O14786
      UniProtKB/TrEMBL
      Q6X907
      Related
      ENSP00000379317.1, ENST00000395995.5
    6. NM_003873.5NP_003864.4  neuropilin-1 isoform a precursor

      See identical proteins and their annotated locations for NP_003864.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform a).
      Source sequence(s)
      AB209641, AL698999, BX648025, BX648250, CR749333, DA702852
      Consensus CDS
      CCDS7177.1
      UniProtKB/Swiss-Prot
      O14786
      UniProtKB/TrEMBL
      Q59F20, Q68DN3, Q6AWA9
      Related
      ENSP00000364001.2, ENST00000374867.6
      Conserved Domains (6) summary
      cd06263
      Location:650803
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      pfam11980
      Location:843920
      DUF3481; Domain of unknown function (DUF3481)
      smart00137
      Location:645804
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00231
      Location:274424
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:27140
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:277423
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    RNA

    1. NR_045259.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AB209641, AL121748, AL353600, AL833608, BX648250
      Related
      ENST00000374875.5, OTTHUMT00000051204

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

      Range
      33177491..33334905 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006717525.2XP_006717588.1  neuropilin-1 isoform X5

      Conserved Domains (6) summary
      cd06263
      Location:615768
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      pfam11980
      Location:808885
      DUF3481; Domain of unknown function (DUF3481)
      smart00137
      Location:610769
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00231
      Location:274424
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:27140
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:277423
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    2. XM_006717524.2XP_006717587.1  neuropilin-1 isoform X4

      Conserved Domains (6) summary
      cd06263
      Location:615769
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      pfam11980
      Location:809886
      DUF3481; Domain of unknown function (DUF3481)
      smart00137
      Location:610770
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00231
      Location:274424
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:27140
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:277423
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    3. XM_006717522.2XP_006717585.1  neuropilin-1 isoform X2

      Conserved Domains (6) summary
      cd06263
      Location:650804
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      pfam11980
      Location:827904
      DUF3481; Domain of unknown function (DUF3481)
      smart00137
      Location:645805
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00231
      Location:274424
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:27140
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:277423
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    4. XM_006717521.2XP_006717584.1  neuropilin-1 isoform X1

      Conserved Domains (6) summary
      cd06263
      Location:650804
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      pfam11980
      Location:844921
      DUF3481; Domain of unknown function (DUF3481)
      smart00137
      Location:645805
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00231
      Location:274424
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:27140
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:277423
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    5. XM_017016866.2XP_016872355.1  neuropilin-1 isoform X6

    6. XM_017016865.2XP_016872354.1  neuropilin-1 isoform X3

    7. XM_011519756.2XP_011518058.1  neuropilin-1 isoform X9

      Conserved Domains (3) summary
      smart00231
      Location:274424
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:27140
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:277423
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    8. XM_011519755.3XP_011518057.1  neuropilin-1 isoform X8

      Conserved Domains (3) summary
      smart00231
      Location:274424
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:27140
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:277423
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    9. XM_006717526.2XP_006717589.1  neuropilin-1 isoform X7

      Conserved Domains (3) summary
      smart00231
      Location:274424
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:27140
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:277423
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
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