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    Crtc2 CREB regulated transcription coactivator 2 [ Mus musculus (house mouse) ]

    Gene ID: 74343, updated on 12-Mar-2017
    Official Symbol
    Crtc2provided by MGI
    Official Full Name
    CREB regulated transcription coactivator 2provided by MGI
    Primary source
    MGI:MGI:1921593
    See related
    Ensembl:ENSMUSG00000027936 Vega:OTTMUSG00000021260
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Torc2; mTORC2; 4632407F12Rik
    Orthologs
    Location:
    3; 3 F1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (90253863..90264125)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (90058203..90068047)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene cAMP responsive element binding protein 3-like 4 Neighboring gene solute carrier family 39 (zinc transporter), member 1 Neighboring gene DENN/MADD domain containing 4B Neighboring gene microRNA 7012 Neighboring gene GATA zinc finger domain containing 2B

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • AMPK signaling pathway, organism-specific biosystem (from KEGG)
      AMPK signaling pathway, organism-specific biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
    • AMPK signaling pathway, conserved biosystem (from KEGG)
      AMPK signaling pathway, conserved biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
    • Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, organism-specific biosystem (from WikiPathways)
      Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Glucagon signaling pathway, organism-specific biosystem (from KEGG)
      Glucagon signaling pathway, organism-specific biosystemGlucagon is conventionally regarded as a counterregulatory hormone for insulin and plays a critical anti-hypoglycemic role by maintaining glucose homeostasis in both animals and humans. To increase ...
    • Glucagon signaling pathway, conserved biosystem (from KEGG)
      Glucagon signaling pathway, conserved biosystemGlucagon is conventionally regarded as a counterregulatory hormone for insulin and plays a critical anti-hypoglycemic role by maintaining glucose homeostasis in both animals and humans. To increase ...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Insulin resistance, organism-specific biosystem (from KEGG)
      Insulin resistance, organism-specific biosystemInsulin resistance is a condition where cells become resistant to the effects of insulin. It is often found in people with health disorders, including obesity, type 2 diabetes mellitus, non-alcoholic...
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cAMP response element binding protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    gluconeogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    histone H3-K9 acetylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of CREB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein homotetramerization IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    toxin transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    CREB-regulated transcription coactivator 2
    Names
    TORC-2
    transducer of CREB protein 2
    transducer of regulated cAMP response element-binding protein 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028881.2NP_083157.1  CREB-regulated transcription coactivator 2

      See identical proteins and their annotated locations for NP_083157.1

      Status: VALIDATED

      Source sequence(s)
      AA276938, AA611164, AC119825, BU612513, BY085181, BY230198, CO040040, CV783724
      Consensus CDS
      CCDS38501.1
      UniProtKB/Swiss-Prot
      Q3U182
      Related
      ENSMUSP00000029545, OTTMUSP00000023505, ENSMUST00000029545, OTTMUST00000050376
      Conserved Domains (3) summary
      pfam12884
      Location:1872
      TORC_N; Transducer of regulated CREB activity, N terminus
      pfam12885
      Location:168317
      TORC_M; Transducer of regulated CREB activity middle domain
      pfam12886
      Location:614691
      TORC_C; Transducer of regulated CREB activity, C terminus

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      90253863..90264125
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502153.1XP_006502216.1  CREB-regulated transcription coactivator 2 isoform X2

      Conserved Domains (3) summary
      pfam12884
      Location:1872
      TORC_N; Transducer of regulated CREB activity, N terminus
      pfam12885
      Location:168317
      TORC_M; Transducer of regulated CREB activity middle domain
      pfam12886
      Location:526603
      TORC_C; Transducer of regulated CREB activity, C terminus
    2. XM_006502152.1XP_006502215.1  CREB-regulated transcription coactivator 2 isoform X1

      Conserved Domains (3) summary
      pfam12884
      Location:1872
      TORC_N; Transducer of regulated CREB activity, N terminus
      pfam12885
      Location:145294
      TORC_M; Transducer of regulated CREB activity middle domain
      pfam12886
      Location:591668
      TORC_C; Transducer of regulated CREB activity, C terminus
    3. XM_006502154.1XP_006502217.1  CREB-regulated transcription coactivator 2 isoform X3

      See identical proteins and their annotated locations for XP_006502217.1

      UniProtKB/TrEMBL
      Q8R1U3
      Conserved Domains (2) summary
      pfam12885
      Location:1138
      TORC_M; Transducer of regulated CREB activity middle domain
      pfam12886
      Location:435512
      TORC_C; Transducer of regulated CREB activity, C terminus

    RNA

    1. XR_001783763.1 RNA Sequence

    2. XR_001783761.1 RNA Sequence

    3. XR_375593.1 RNA Sequence

      Related
      ENSMUST00000184882, OTTMUST00000050380
    4. XR_001783762.1 RNA Sequence

      Related
      ENSMUST00000130002
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