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    SLCO2B1 solute carrier organic anion transporter family member 2B1 [ Homo sapiens (human) ]

    Gene ID: 11309, updated on 22-Apr-2017
    Official Symbol
    SLCO2B1provided by HGNC
    Official Full Name
    solute carrier organic anion transporter family member 2B1provided by HGNC
    Primary source
    HGNC:HGNC:10962
    See related
    Ensembl:ENSG00000137491 MIM:604988; Vega:OTTHUMG00000165420
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OATPB; OATP-B; OATP2B1; SLC21A9
    Summary
    This locus encodes a member of the organic anion-transporting polypeptide family of membrane proteins. The protein encoded by this locus may function in regulation of placental uptake of sulfated steroids. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010]
    Orthologs
    Location:
    11q13.4
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 11 NC_000011.10 (75150987..75206400)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (74862032..74917445)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984358 Neighboring gene olfactory receptor family 2 subfamily AT member 1 pseudogene Neighboring gene uncharacterized LOC105369388 Neighboring gene zinc finger DHHC-type containing 20 pseudogene 3

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • KIAA0880, DKFZp686E0517

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    sodium-independent organic anion transport TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    solute carrier organic anion transporter family member 2B1
    Names
    OATP-RP2
    organic anion transporter B
    organic anion transporter polypeptide-related protein 2
    solute carrier family 21 (organic anion transporter), member 9

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027921.1 RefSeqGene

      Range
      5001..60414
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001145211.2NP_001138683.1  solute carrier organic anion transporter family member 2B1 isoform 2

      See identical proteins and their annotated locations for NP_001138683.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon compared to transcript variant 1. This results in translation initiation from an in-frame downstream AUG and an isoform (2) with a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AF205073, BC041095, CK299190, DC362722
      Consensus CDS
      CCDS44683.1
      UniProtKB/Swiss-Prot
      O94956
      Related
      ENSP00000388912.2, OTTHUMP00000229681, ENST00000428359.6, OTTHUMT00000383944
      Conserved Domains (3) summary
      cd06174
      Location:34230
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:463520
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:28625
      OATP; Organic Anion Transporter Polypeptide (OATP) family
    2. NM_001145212.2NP_001138684.1  solute carrier organic anion transporter family member 2B1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) is missing 3 consecutive coding exons from the 5' end compared to transcript variant 1. However, it maintains the reading frame and results in a shorter isoform (3) lacking a protein segment from the N-terminus compared to isoform 1.
      Source sequence(s)
      BC041095, CK299190, DC343392
      Consensus CDS
      CCDS53679.1
      UniProtKB/Swiss-Prot
      O94956
      UniProtKB/TrEMBL
      A0A0A0MTF1
      Related
      ENSP00000436324.1, OTTHUMP00000229674, ENST00000525650.5, OTTHUMT00000383937
      Conserved Domains (2) summary
      cd01330
      Location:341398
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:48503
      OATP; Organic Anion Transporter Polypeptide (OATP) family
    3. NM_007256.4NP_009187.1  solute carrier organic anion transporter family member 2B1 isoform 1

      See identical proteins and their annotated locations for NP_009187.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      BC041095, CK299190, DC343392
      Consensus CDS
      CCDS8235.1
      UniProtKB/Swiss-Prot
      O94956
      UniProtKB/TrEMBL
      A0A024R5I4
      Related
      ENSP00000289575.5, OTTHUMP00000229671, ENST00000289575.9, OTTHUMT00000383933
      Conserved Domains (3) summary
      cd06174
      Location:56252
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:485542
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:50647
      OATP; Organic Anion Transporter Polypeptide (OATP) family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p7 Primary Assembly

      Range
      75150987..75206400
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017017157.1XP_016872646.1  solute carrier organic anion transporter family member 2B1 isoform X1

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      74745634..74801048
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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