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    Hras Harvey rat sarcoma virus oncogene [ Mus musculus (house mouse) ]

    Gene ID: 15461, updated on 22-Apr-2017
    Official Symbol
    Hrasprovided by MGI
    Official Full Name
    Harvey rat sarcoma virus oncogeneprovided by MGI
    Primary source
    MGI:MGI:96224
    See related
    Ensembl:ENSMUSG00000025499 Vega:OTTMUSG00000016471
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ras; H-ras; Hras1; Kras2; Ha-ras; Hras-1; c-H-ras; c-rasHa; c-Ha-ras; Harvey-ras
    Orthologs
    Location:
    7 F5; 7 86.48 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (141189934..141194004, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (148375833..148379903, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene ribonuclease/angiogenin inhibitor 1 Neighboring gene ribosomal protein S9 pseudogene Neighboring gene leucine rich repeat containing 56 Neighboring gene lamin tail domain containing 2 Neighboring gene Ras association (RalGDS/AF-6) domain family (N-terminal) member 7

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GDP binding ISO
    Inferred from Sequence Orthology
    more info
     
    GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    Ras protein signal transduction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    Ras protein signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    T cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    T-helper 1 type immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    cell aging IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell cycle arrest ISO
    Inferred from Sequence Orthology
    more info
     
    cell proliferation IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    cellular response to gamma radiation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular senescence ISO
    Inferred from Sequence Orthology
    more info
     
    defense response to protozoan IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intrinsic apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic cell cycle checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of neuron apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of actin cytoskeleton reorganization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of interferon-gamma production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of miRNA metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ruffle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    protein heterooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of long-term neuronal synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    small GTPase mediated signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Preferred Names
    GTPase HRas
    Names
    H-Ras-1
    H-ras 1 protein
    Harvey rat sarcoma virus oncogene 1
    c-Ha-ras p21 protein
    c-Ha-ras transgene
    p21ras
    transforming protein P21
    NP_001123915.1
    NP_001123916.1
    NP_032310.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130443.1NP_001123915.1  GTPase HRas isoform 1

      See identical proteins and their annotated locations for NP_001123915.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR, compared to variant 1, and encodes isoform 1. Isoform 1 is also known as p21. Variants 1 and 3 encode the same protein.
      Source sequence(s)
      BC061885, BU924724, CK788792
      Consensus CDS
      CCDS22003.1
      UniProtKB/Swiss-Prot
      Q61411
      Related
      ENSMUSP00000095570.4, OTTMUSP00000017718, ENSMUST00000097957.10, OTTMUST00000039711
      Conserved Domains (2) summary
      cd04138
      Location:3164
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
      smart00173
      Location:16166
      RAS; Ras subfamily of RAS small GTPases
    2. NM_001130444.1NP_001123916.1  GTPase HRas isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and includes an alternate exon in its 3' coding region, compared to variant 1. The resulting isoform (2) contains a distinct C-terminus and is shorter than isoform 1. Isoform 2 is also known as p21.
      Source sequence(s)
      BC061885, BI731283, BQ963436, CK788792
      Consensus CDS
      CCDS52439.1
      UniProtKB/Swiss-Prot
      Q61411
      Related
      ENSMUSP00000132110.1, ENSMUST00000168550.7
      Conserved Domains (2) summary
      cd04138
      Location:3150
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
      smart00010
      Location:16150
      small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
    3. NM_008284.2NP_032310.2  GTPase HRas isoform 1

      See identical proteins and their annotated locations for NP_032310.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform 1. Isoform 1 is also known as p21. Variants 1 and 3 encode the same protein.
      Source sequence(s)
      BC061885, CK788792
      Consensus CDS
      CCDS22003.1
      UniProtKB/Swiss-Prot
      Q61411
      Related
      ENSMUSP00000026572.4, OTTMUSP00000017719, ENSMUST00000026572.10, OTTMUST00000039712
      Conserved Domains (2) summary
      cd04138
      Location:3164
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
      smart00173
      Location:16166
      RAS; Ras subfamily of RAS small GTPases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      141189934..141194004 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006536159.2XP_006536222.2  GTPase HRas isoform X1

      See identical proteins and their annotated locations for XP_006536222.2

      UniProtKB/Swiss-Prot
      Q61411
      Conserved Domains (2) summary
      cd04138
      Location:3164
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
      smart00173
      Location:16166
      RAS; Ras subfamily of RAS small GTPases

    RNA

    1. XR_389950.2 RNA Sequence

    2. XR_389951.2 RNA Sequence

    3. XR_389952.2 RNA Sequence

      Related
      ENSMUST00000124971.1, OTTMUST00000039714
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