Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    PKD1 polycystin 1, transient receptor potential channel interacting [ Homo sapiens (human) ]

    Gene ID: 5310, updated on 20-Apr-2017
    Official Symbol
    PKD1provided by HGNC
    Official Full Name
    polycystin 1, transient receptor potential channel interactingprovided by HGNC
    Primary source
    HGNC:HGNC:9008
    See related
    Ensembl:ENSG00000008710 MIM:601313; Vega:OTTHUMG00000155795
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PBP; PC1; Pc-1; TRPP1
    Summary
    This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene. Also, six pseudogenes, closely linked in a known duplicated region on chromosome 16p, have been described. [provided by RefSeq, Oct 2008]
    Orthologs
    Location:
    16p13.3
    Exon count:
    51
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 16 NC_000016.10 (2088708..2135898, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2138709..2185899, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene SLC9A3 regulator 2 Neighboring gene nth like DNA glycosylase 1 Neighboring gene tuberous sclerosis 2 Neighboring gene uncharacterized LOC105371049 Neighboring gene microRNA 1225 Neighboring gene microRNA 6511b-1 Neighboring gene microRNA 3180-5 Neighboring gene microRNA 4516 Neighboring gene RAB26, member RAS oncogene family

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Polycystic kidney disease, adult type
    MedGen: C0085413 OMIM: 173900 GeneReviews: Not available
    Compare labs

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated (2012-02-22)

    ClinGen Genome Curation Page
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated (2012-02-22)

    ClinGen Genome Curation Page

    Replication interactions

    Interaction Pubs
    Knockdown of polycystic kidney disease 1, autosomal dominant (PKD1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    • Cargo trafficking to the periciliary membrane, organism-specific biosystem (from REACTOME)
      Cargo trafficking to the periciliary membrane, organism-specific biosystemProteomic studies suggest that the cilium is home to approximately a thousand proteins, and has a unique protein and lipid make up relative to the bulk cytoplasm and plasma membrane (Pazour et al, 20...
    • Cilium Assembly, organism-specific biosystem (from REACTOME)
      Cilium Assembly, organism-specific biosystemCilia are membrane covered organelles that extend from the surface of eukaryotic cells. Cilia may be motile, such as respiratory cilia) or non-motile (such as the primary cilium) and are distinguishe...
    • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
      Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...
    • Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway, organism-specific biosystem (from WikiPathways)
      Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway, organism-specific biosystemThis pathway Involved in chemo-resistance of cells in bladder cancer begins with LOXL2 activation of CDC37 and COL2A1. COL2A1 activates the complex NRF1/2 and two other complexes that trigger RTK/MAP...
    • VxPx cargo-targeting to cilium, organism-specific biosystem (from REACTOME)
      VxPx cargo-targeting to cilium, organism-specific biosystemA number of membrane proteins destined for the ciliary membrane are recognized by ARF4 in the trans-Golgi network, initiating the formation of a ciliary targeting complex that directs the passage of ...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    calcium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    ion channel binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    JAK-STAT cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    anatomical structure morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    branching morphogenesis of an epithelial tube IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    calcium-independent cell-matrix adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    cartilage condensation IEA
    Inferred from Electronic Annotation
    more info
     
    cartilage development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cell cycle arrest ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell-matrix adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    cytoplasmic sequestering of transcription factor ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    detection of mechanical stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    detection of mechanical stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    digestive tract development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    embryonic placenta development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    establishment of cell polarity IEA
    Inferred from Electronic Annotation
    more info
     
    genitalia development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    heart development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    homophilic cell adhesion via plasma membrane adhesion molecules TAS
    Traceable Author Statement
    more info
    PubMed 
    in utero embryonic development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    kidney development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    liver development IEA
    Inferred from Electronic Annotation
    more info
     
    lung epithelium development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    lymph vessel morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    mesonephric duct development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    mesonephric tubule development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    metanephric ascending thin limb development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    metanephric collecting duct development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    metanephric distal tubule morphogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    metanephric proximal tubule development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    neural tube development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    peptidyl-serine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    placenta blood vessel development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein export from nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of mitotic spindle organization IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of proteasomal protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to fluid shear stress IEA
    Inferred from Electronic Annotation
    more info
     
    single organismal cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    skin development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    spinal cord development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi membrane TAS
    Traceable Author Statement
    more info
     
    Golgi-associated vesicle membrane TAS
    Traceable Author Statement
    more info
     
    basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    ciliary membrane TAS
    Traceable Author Statement
    more info
     
    cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    lateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    motile cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    polycystin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    polycystin-1
    Names
    autosomal dominant polycystic kidney disease 1 protein
    polycystic kidney disease 1 (autosomal dominant)
    polycystic kidney disease-associated protein
    transient receptor potential cation channel, subfamily P, member 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008617.1 RefSeqGene

      Range
      5001..54511
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000296.3NP_000287.3  polycystin-1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_000287.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate acceptor splice site, 3 nt downstream of that used by transcript variant 1, at the junction of one of the coding exons. This results in an isoform (2) that is 1 aa shorter than isoform 1.
      Source sequence(s)
      AC093513, L33243, U24497
      Consensus CDS
      CCDS45385.1
      UniProtKB/Swiss-Prot
      P98161
      Related
      ENSP00000399501.1, OTTHUMP00000208670, ENST00000423118.5, OTTHUMT00000341689
      Conserved Domains (12) summary
      TIGR00864
      Location:972728
      PCC; polycystin cation channel protein
      smart00303
      Location:30113060
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00034
      Location:406531
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      smart00082
      Location:125177
      LRRCT; Leucine rich repeat C-terminal domain
      smart00089
      Location:11281209
      PKD; Repeats in polycystic kidney disease 1 (PKD1) and other proteins
      smart00321
      Location:177271
      WSC; present in yeast cell wall integrity and stress response component proteins
      COG4886
      Location:50126
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd01752
      Location:31183237
      PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...
      sd00031
      Location:7092
      LRR_1; leucine-rich repeat [structural motif]
      pfam00801
      Location:17231792
      PKD; PKD domain
      pfam04479
      Location:38743956
      RTA1; RTA1 like protein
      pfam08016
      Location:37104112
      PKD_channel; Polycystin cation channel
    2. NM_001009944.2NP_001009944.2  polycystin-1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001009944.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC093513, L33243, U24497
      Consensus CDS
      CCDS32369.1
      UniProtKB/Swiss-Prot
      P98161
      Related
      ENSP00000262304.4, OTTHUMP00000208669, ENST00000262304.8, OTTHUMT00000341688
      Conserved Domains (12) summary
      TIGR00864
      Location:972728
      PCC; polycystin cation channel protein
      smart00303
      Location:30113060
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00034
      Location:406531
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      smart00082
      Location:125177
      LRRCT; Leucine rich repeat C-terminal domain
      smart00089
      Location:11281209
      PKD; Repeats in polycystic kidney disease 1 (PKD1) and other proteins
      smart00321
      Location:177271
      WSC; present in yeast cell wall integrity and stress response component proteins
      COG4886
      Location:50126
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd01752
      Location:31183237
      PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...
      sd00031
      Location:7092
      LRR_1; leucine-rich repeat [structural motif]
      pfam00801
      Location:17231792
      PKD; PKD domain
      pfam04479
      Location:38753957
      RTA1; RTA1 like protein
      pfam08016
      Location:37114113
      PKD_channel; Polycystin cation channel

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p7 Primary Assembly

      Range
      2088708..2135898 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011522532.2XP_011520834.1  polycystin-1 isoform X4

      Conserved Domains (11) summary
      TIGR00864
      Location:732712
      PCC; polycystin cation channel protein
      smart00303
      Location:29953044
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00034
      Location:382507
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      smart00082
      Location:101153
      LRRCT; Leucine rich repeat C-terminal domain
      smart00089
      Location:11121193
      PKD; Repeats in polycystic kidney disease 1 (PKD1) and other proteins
      smart00321
      Location:153247
      WSC; present in yeast cell wall integrity and stress response component proteins
      cd01752
      Location:31023221
      PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...
      sd00031
      Location:4868
      LRR_1; leucine-rich repeat [structural motif]
      pfam00801
      Location:17071776
      PKD; PKD domain
      pfam04479
      Location:38593941
      RTA1; RTA1 like protein
      pfam08016
      Location:36954097
      PKD_channel; Polycystin cation channel
    2. XM_011522530.2XP_011520832.1  polycystin-1 isoform X3

      Conserved Domains (12) summary
      TIGR00864
      Location:972736
      PCC; polycystin cation channel protein
      smart00303
      Location:30193068
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00034
      Location:406531
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      smart00082
      Location:125177
      LRRCT; Leucine rich repeat C-terminal domain
      smart00089
      Location:11361217
      PKD; Repeats in polycystic kidney disease 1 (PKD1) and other proteins
      smart00321
      Location:177271
      WSC; present in yeast cell wall integrity and stress response component proteins
      COG4886
      Location:50126
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd01752
      Location:31263245
      PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...
      sd00031
      Location:7092
      LRR_1; leucine-rich repeat [structural motif]
      pfam00801
      Location:17311800
      PKD; PKD domain
      pfam04479
      Location:38833965
      RTA1; RTA1 like protein
      pfam08016
      Location:37194121
      PKD_channel; Polycystin cation channel
    3. XM_011522534.2XP_011520836.1  polycystin-1 isoform X5

      Conserved Domains (11) summary
      TIGR00864
      Location:272666
      PCC; polycystin cation channel protein
      smart00303
      Location:29492998
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00034
      Location:336461
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      smart00082
      Location:55107
      LRRCT; Leucine rich repeat C-terminal domain
      smart00089
      Location:10661147
      PKD; Repeats in polycystic kidney disease 1 (PKD1) and other proteins
      smart00321
      Location:107201
      WSC; present in yeast cell wall integrity and stress response component proteins
      cd01752
      Location:30563175
      PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...
      sd00031
      Location:2346
      LRR_1; leucine-rich repeat [structural motif]
      pfam00801
      Location:16611730
      PKD; PKD domain
      pfam04479
      Location:38133895
      RTA1; RTA1 like protein
      pfam08016
      Location:36494051
      PKD_channel; Polycystin cation channel
    4. XM_011522529.2XP_011520831.1  polycystin-1 isoform X2

      Conserved Domains (11) summary
      TIGR00864
      Location:1152746
      PCC; polycystin cation channel protein
      smart00303
      Location:30293078
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00034
      Location:424549
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      smart00082
      Location:143195
      LRRCT; Leucine rich repeat C-terminal domain
      smart00089
      Location:11461227
      PKD; Repeats in polycystic kidney disease 1 (PKD1) and other proteins
      smart00321
      Location:195289
      WSC; present in yeast cell wall integrity and stress response component proteins
      cd01752
      Location:31363255
      PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...
      sd00031
      Location:111134
      LRR_1; leucine-rich repeat [structural motif]
      pfam00801
      Location:17411810
      PKD; PKD domain
      pfam04479
      Location:38923974
      RTA1; RTA1 like protein
      pfam08016
      Location:37284130
      PKD_channel; Polycystin cation channel
    5. XM_011522528.2XP_011520830.1  polycystin-1 isoform X1

      Conserved Domains (11) summary
      TIGR00864
      Location:1152746
      PCC; polycystin cation channel protein
      smart00303
      Location:30293078
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00034
      Location:424549
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      smart00082
      Location:143195
      LRRCT; Leucine rich repeat C-terminal domain
      smart00089
      Location:11461227
      PKD; Repeats in polycystic kidney disease 1 (PKD1) and other proteins
      smart00321
      Location:195289
      WSC; present in yeast cell wall integrity and stress response component proteins
      cd01752
      Location:31363255
      PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...
      sd00031
      Location:111134
      LRR_1; leucine-rich repeat [structural motif]
      pfam00801
      Location:17411810
      PKD; PKD domain
      pfam04479
      Location:38933975
      RTA1; RTA1 like protein
      pfam08016
      Location:37294131
      PKD_channel; Polycystin cation channel
    6. XM_011522535.2XP_011520837.1  polycystin-1 isoform X6

      Conserved Domains (8) summary
      smart00303
      Location:23112360
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00089
      Location:428509
      PKD; Repeats in polycystic kidney disease 1 (PKD1) and other proteins
      COG3291
      Location:355581
      COG3291; PKD repeat [Function unknown]
      cd01752
      Location:24182537
      PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...
      pfam00801
      Location:10231092
      PKD; PKD domain
      pfam02010
      Location:14711914
      REJ; REJ domain
      pfam04479
      Location:31753257
      RTA1; RTA1 like protein
      pfam08016
      Location:30113413
      PKD_channel; Polycystin cation channel
    7. XM_017023285.1XP_016878774.1  polycystin-1 isoform X8

    8. XM_005255370.3XP_005255427.1  polycystin-1 isoform X9

      Conserved Domains (8) summary
      smart00303
      Location:19962045
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00089
      Location:113194
      PKD; Repeats in polycystic kidney disease 1 (PKD1) and other proteins
      COG3291
      Location:40266
      COG3291; PKD repeat [Function unknown]
      cd01752
      Location:21032222
      PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...
      pfam00801
      Location:708777
      PKD; PKD domain
      pfam02010
      Location:11561599
      REJ; REJ domain
      pfam04479
      Location:28602942
      RTA1; RTA1 like protein
      pfam08016
      Location:26963098
      PKD_channel; Polycystin cation channel
    9. XM_011522537.2XP_011520839.1  polycystin-1 isoform X7

      Conserved Domains (8) summary
      smart00303
      Location:20372086
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00089
      Location:154235
      PKD; Repeats in polycystic kidney disease 1 (PKD1) and other proteins
      COG3291
      Location:81307
      COG3291; PKD repeat [Function unknown]
      cd01752
      Location:21442263
      PLAT_polycystin; PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological ...
      pfam00801
      Location:749818
      PKD; PKD domain
      pfam02010
      Location:11971640
      REJ; REJ domain
      pfam04479
      Location:29012983
      RTA1; RTA1 like protein
      pfam08016
      Location:27373139
      PKD_channel; Polycystin cation channel

    Alternate CHM1_1.1

    Genomic

    1. NC_018927.2 Alternate CHM1_1.1

      Range
      2138626..2185837 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center