Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    Hspa1a heat shock 70kD protein 1A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24472, updated on 9-Apr-2017
    Official Symbol
    Hspa1aprovided by RGD
    Official Full Name
    heat shock 70kD protein 1Aprovided by RGD
    Primary source
    RGD:2840
    See related
    Ensembl:ENSRNOG00000050647 Vega:OTTRNOG00000001807
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    HSP72; Hspa1; Hspa2; Hspa1b; HSP70.1; Hsp70-1; Hsp70-2
    Summary
    heat inducible gene; induced by global ischemia and kainic acid-induced seizures [RGD, Feb 2006]
    Annotation information
    Annotation category: partial on reference assembly
    Location:
    20p12
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (4877638..4880112, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 20 NC_005119.3 (7029038..7033025, complement) , (4802576..4804849, complement)

    Chromosome 20 - NC_005119.4Genomic Context describing neighboring genes Neighboring gene lymphotoxin-beta Neighboring gene uncharacterized LOC102549726 Neighboring gene heat shock protein family A (Hsp70) member 1 like Neighboring gene RT1 class I, locus CE5 Neighboring gene LOC224733l-4 pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    ATPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    ATPase activity, coupled ISO
    Inferred from Sequence Orthology
    more info
     
    C3HC4-type RING finger domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    G-protein coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    NF-kappaB binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II transcription corepressor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cadherin binding ISO
    Inferred from Sequence Orthology
    more info
     
    denatured protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    disordered domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding involved in protein folding ISO
    Inferred from Sequence Orthology
    more info
     
    receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    unfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    ATP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    binding of sperm to zona pellucida ISO
    Inferred from Sequence Orthology
    more info
     
    cellular heat acclimation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to heat ISO
    Inferred from Sequence Orthology
    more info
     
    chaperone-mediated protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    defense response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell growth ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of inclusion body assembly ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    NOT negative regulation of myeloid cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription from RNA polymerase II promoter in response to stress ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription from RNA polymerase II promoter in response to stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of vasoconstriction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of T cell mediated cytotoxicity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of endoribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mRNA endonucleolytic cleavage involved in unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of microtubule nucleation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of microtubule nucleation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    protein refolding ISO
    Inferred from Sequence Orthology
    more info
     
    protein refolding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    NOT regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitotic spindle assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    response to heat ISO
    Inferred from Sequence Orthology
    more info
     
    response to unfolded protein IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to unfolded protein ISO
    Inferred from Sequence Orthology
    more info
     
    response to unfolded protein ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    aggresome ISO
    Inferred from Sequence Orthology
    more info
     
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    blood microparticle ISO
    Inferred from Sequence Orthology
    more info
     
    cell body ISO
    Inferred from Sequence Orthology
    more info
     
    centriole ISO
    Inferred from Sequence Orthology
    more info
     
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    inclusion body ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     
    membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear speck ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    zona pellucida receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    heat shock 70 kDa protein 1B
    Names
    HSP70-1/HSP70-2
    HSP70.1/2
    HSP70.1/HSP70.2
    Heat shock 70 kDa protein 1
    heat shock 70 kDa protein 1/2
    heat shock 70 kDa protein 1A/1B
    heat shock protein 70-1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031971.2NP_114177.2  heat shock 70 kDa protein 1B

      See identical proteins and their annotated locations for NP_114177.2

      Status: PROVISIONAL

      Source sequence(s)
      BX883045
      UniProtKB/Swiss-Prot
      P0DMW0, P0DMW1
      Related
      ENSRNOP00000075599.1, OTTRNOP00000001715, ENSRNOT00000081924.1, OTTRNOT00000002910
      Conserved Domains (2) summary
      cd10233
      Location:6381
      HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins
      PTZ00009
      Location:1641
      PTZ00009; heat shock 70 kDa protein; Provisional

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005119.4 Reference Rnor_6.0 Primary Assembly

      Range
      4877638..4880112 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000088.1 Alternate Rn_Celera

      Range
      4167705..4171749 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center