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    Gja1 gap junction protein, alpha 1 [ Mus musculus (house mouse) ]

    Gene ID: 14609, updated on 25-Mar-2017
    Official Symbol
    Gja1provided by MGI
    Official Full Name
    gap junction protein, alpha 1provided by MGI
    Primary source
    MGI:MGI:95713
    See related
    Ensembl:ENSMUSG00000050953
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cx43; Npm1; Cnx43; Gja-1; AU042049; AW546267; Cx43alpha1; connexin43
    Orthologs
    Location:
    10 B4; 10 28.64 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (56377300..56390419)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (56097106..56110225)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene TBC1 domain family, member 32 Neighboring gene male-specific lethal 3-like 2 (Drosophila) Neighboring gene UPF0183 protein C16orf70 homolog Neighboring gene ribosomal protein S8, pseudogene 1 Neighboring gene predicted gene, 36460 Neighboring gene predicted gene, 36517

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    beta-tubulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    connexin binding ISO
    Inferred from Sequence Orthology
    more info
     
    gap junction channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    gap junction channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    gap junction channel activity involved in cardiac conduction electrical coupling TAS
    Traceable Author Statement
    more info
    PubMed 
    gap junction channel activity involved in cell communication by electrical coupling ISO
    Inferred from Sequence Orthology
    more info
     
    ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein tyrosine kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    scaffold protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    signal transducer activity ISO
    Inferred from Sequence Orthology
    more info
     
    transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    ATP transport ISO
    Inferred from Sequence Orthology
    more info
     
    adult heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    atrial ventricular junction remodeling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac conduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell communication ISO
    Inferred from Sequence Orthology
    more info
     
    cell communication by chemical coupling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell communication by electrical coupling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell communication by electrical coupling ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell junction organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell-cell signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell signaling ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to pH IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chronic inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    embryonic digit morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic heart tube development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epicardial cell to mesenchymal cell transition TAS
    Traceable Author Statement
    more info
    PubMed 
    epithelial cell maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment of epithelial cell polarity TAS
    Traceable Author Statement
    more info
    PubMed 
    heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart looping IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    lens development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    milk ejection reflex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cardiac muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron projection morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of behavioral fear response ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of blood vessel diameter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell communication by chemical coupling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of glomerular filtration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of striated muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
     
    protein oligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of atrial cardiac muscle cell membrane depolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of bicellular tight junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of blood vessel remodeling TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of bone remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of ventricular cardiac muscle cell membrane depolarization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of ventricular cardiac muscle cell membrane depolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of ventricular cardiac muscle cell membrane repolarization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of ventricular cardiac muscle cell membrane repolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to pH ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    skeletal muscle tissue regeneration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    vascular transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    connexin complex ISO
    Inferred from Sequence Orthology
    more info
     
    contractile fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    endosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    fascia adherens IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fascia adherens ISO
    Inferred from Sequence Orthology
    more info
     
    focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    gap junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    gap junction ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intercalated disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intercalated disc ISO
    Inferred from Sequence Orthology
    more info
     
    intermediate filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    late endosome ISO
    Inferred from Sequence Orthology
    more info
     
    lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    multivesicular body ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    gap junction alpha-1 protein
    Names
    alpha 1 connexin
    connexin-43
    gap junction 43 kDa heart protein
    gap junction membrane channel protein alpha 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010288.3NP_034418.1  gap junction alpha-1 protein

      See identical proteins and their annotated locations for NP_034418.1

      Status: VALIDATED

      Source sequence(s)
      AK081668, AK145692, BY061175
      Consensus CDS
      CCDS23851.1
      UniProtKB/Swiss-Prot
      P23242
      UniProtKB/TrEMBL
      Q8C4N2
      Related
      ENSMUSP00000064536, ENSMUST00000068581
      Conserved Domains (4) summary
      smart00037
      Location:4376
      CNX; Connexin homologues
      smart01089
      Location:165231
      Connexin_CCC; Gap junction channel protein cysteine-rich domain
      pfam00029
      Location:3233
      Connexin; Connexin
      pfam03508
      Location:293312
      Connexin43; Gap junction alpha-1 protein (Cx43)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      56377300..56390419
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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