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    Kcnj10 potassium voltage-gated channel subfamily J member 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29718, updated on 7-May-2017
    Official Symbol
    Kcnj10provided by RGD
    Official Full Name
    potassium voltage-gated channel subfamily J member 10provided by RGD
    Primary source
    RGD:61822
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    inwardly rectifying K+ channel; specifically expressed in brain [RGD, Feb 2006]
    Orthologs
    Location:
    13q24
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (90722945..90753338)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 13 NC_005112.3 (95245046..95274535)

    Chromosome 13 - NC_005112.4Genomic Context describing neighboring genes Neighboring gene ATPase Na+/K+ transporting subunit alpha 2 Neighboring gene immunoglobulin superfamily, member 8 Neighboring gene potassium voltage-gated channel subfamily J member 9 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class M Neighboring gene uncharacterized LOC103692291

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP-activated inward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    inward rectifier potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    inward rectifier potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    L-glutamate import IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    adult walking behavior IEA
    Inferred from Electronic Annotation
    more info
     
    adult walking behavior ISO
    Inferred from Sequence Orthology
    more info
     
    central nervous system myelination IEA
    Inferred from Electronic Annotation
    more info
     
    central nervous system myelination ISO
    Inferred from Sequence Orthology
    more info
     
    glutamate reuptake IEA
    Inferred from Electronic Annotation
    more info
     
    glutamate reuptake ISO
    Inferred from Sequence Orthology
    more info
     
    inflammatory response IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    membrane hyperpolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oligodendrocyte development ISO
    Inferred from Sequence Orthology
    more info
     
    optic nerve development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    potassium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    potassium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    potassium ion import IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of long-term neuronal synaptic plasticity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of long-term neuronal synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of resting membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of resting membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to blue light IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to glucocorticoid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to mineralocorticoid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    visual perception IEA
    Inferred from Electronic Annotation
    more info
     
    visual perception ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    astrocyte projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    microvillus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    presynapse IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    ATP-sensitive inward rectifier potassium channel 10
    Names
    ATP-sensitive inward rectifier potassium channel KAB-2
    BIR10
    BIRK1
    brain-specific inwardly rectifying K(+) channel 1
    inward rectifier K(+) channel Kir4.1
    kir4.1
    potassium channel, inwardly rectifying subfamily J member 10
    potassium inwardly-rectifying channel, subfamily J, member 10

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031602.2NP_113790.2  ATP-sensitive inward rectifier potassium channel 10

      See identical proteins and their annotated locations for NP_113790.2

      Status: VALIDATED

      Source sequence(s)
      AC095300, AC112551
      UniProtKB/Swiss-Prot
      P49655
      Conserved Domains (1) summary
      pfam01007
      Location:31362
      IRK; Inward rectifier potassium channel

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005112.4 Reference Rnor_6.0 Primary Assembly

      Range
      90722945..90753338
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017598774.1XP_017454263.1  ATP-sensitive inward rectifier potassium channel 10 isoform X1

      UniProtKB/Swiss-Prot
      P49655
      Conserved Domains (1) summary
      pfam01007
      Location:31362
      IRK; Inward rectifier potassium channel
    2. XM_008769737.2XP_008767959.1  ATP-sensitive inward rectifier potassium channel 10 isoform X1

      See identical proteins and their annotated locations for XP_008767959.1

      UniProtKB/Swiss-Prot
      P49655
      Conserved Domains (1) summary
      pfam01007
      Location:31362
      IRK; Inward rectifier potassium channel
    3. XM_017598775.1XP_017454264.1  ATP-sensitive inward rectifier potassium channel 10 isoform X2

    Alternate Rn_Celera

    Genomic

    1. AC_000081.1 Alternate Rn_Celera

      Range
      84412223..84441711
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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