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    Chrna7 cholinergic receptor nicotinic alpha 7 subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25302, updated on 12-Sep-2017
    Official Symbol
    Chrna7provided by RGD
    Official Full Name
    cholinergic receptor nicotinic alpha 7 subunitprovided by RGD
    Primary source
    RGD:2348
    See related
    Ensembl:ENSRNOG00000010853
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    BTX; NARAD; nAChRa7
    Summary
    subunit of nicotinic acetylcholline receptor; may mediate nicotine induced increase in tyrosine hydroxylase expression; may play a role in neuroprotection [RGD, Feb 2006]
    Annotation information
    Annotation category: suggests misassembly
    Orthologs
    Location:
    1q22
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (123897341..124039263, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (125029451..125158153, complement)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548067 Neighboring gene similar to non-POU domain containing, octamer-binding Neighboring gene F-box/WD repeat-containing protein 11-like Neighboring gene uncharacterized LOC102548165 Neighboring gene uncharacterized LOC102548323 Neighboring gene OTU deubiquitinase 7A Neighboring gene similar to ribosomal protein L36

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ATPase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acetylcholine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acetylcholine binding IEA
    Inferred from Electronic Annotation
    more info
     
    acetylcholine binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acetylcholine binding ISO
    Inferred from Sequence Orthology
    more info
     
    acetylcholine receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    acetylcholine-gated cation-selective channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acetylcholine-gated cation-selective channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    acetylcholine-gated cation-selective channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acetylcholine-gated cation-selective channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    adenylate cyclase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    amyloid-beta binding IEA
    Inferred from Electronic Annotation
    more info
     
    amyloid-beta binding ISO
    Inferred from Sequence Orthology
    more info
     
    chloride channel regulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    chloride channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    drug binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ion channel activity IC
    Inferred by Curator
    more info
    PubMed 
    ion channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    scaffold protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    toxic substance binding IEA
    Inferred from Electronic Annotation
    more info
     
    toxic substance binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    B cell activation IEA
    Inferred from Electronic Annotation
    more info
     
    B cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    T cell activation IEA
    Inferred from Electronic Annotation
    more info
     
    T cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    acetylcholine receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    activation of MAPK activity IEA
    Inferred from Electronic Annotation
    more info
     
    activation of MAPK activity ISO
    Inferred from Sequence Orthology
    more info
     
    associative learning IEA
    Inferred from Electronic Annotation
    more info
     
    associative learning ISO
    Inferred from Sequence Orthology
    more info
     
    behavioral response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    behavioral response to ethanol ISO
    Inferred from Sequence Orthology
    more info
     
    behavioral response to nicotine IEA
    Inferred from Electronic Annotation
    more info
     
    behavioral response to nicotine ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    cellular calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    cellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    cognition ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite arborization IEA
    Inferred from Electronic Annotation
    more info
     
    dendrite arborization ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic spine organization IEA
    Inferred from Electronic Annotation
    more info
     
    dendritic spine organization ISO
    Inferred from Sequence Orthology
    more info
     
    dopamine biosynthetic process IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
     
    flagellated sperm motility IEA
    Inferred from Electronic Annotation
    more info
     
    flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
     
    generation of ovulation cycle rhythm IEA
    Inferred from Electronic Annotation
    more info
     
    generation of ovulation cycle rhythm ISO
    Inferred from Sequence Orthology
    more info
     
    ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    learning or memory ISO
    Inferred from Sequence Orthology
    more info
     
    memory IDA
    Inferred from Direct Assay
    more info
    PubMed 
    memory IEA
    Inferred from Electronic Annotation
    more info
     
    memory ISO
    Inferred from Sequence Orthology
    more info
     
    modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    modulation of excitatory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of amyloid-beta formation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of amyloid-beta formation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interleukin-1 beta production IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interleukin-6 production IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of tumor necrosis factor production IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal action potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ovulation cycle ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of CoA-transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of CoA-transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of amyloid-beta formation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of amyloid-beta formation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of excitatory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of long-term synaptic potentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of long-term synaptic potentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of amyloid fibril formation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of amyloid fibril formation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of amyloid precursor protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of membrane potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of neuron death IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of norepinephrine secretion IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of norepinephrine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of synaptic transmission, dopaminergic IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of synaptic transmission, dopaminergic ISO
    Inferred from Sequence Orthology
    more info
     
    response to acetylcholine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to acetylcholine IEA
    Inferred from Electronic Annotation
    more info
     
    response to acetylcholine ISO
    Inferred from Sequence Orthology
    more info
     
    response to amyloid-beta IEA
    Inferred from Electronic Annotation
    more info
     
    response to amyloid-beta ISO
    Inferred from Sequence Orthology
    more info
     
    response to cold IEA
    Inferred from Electronic Annotation
    more info
     
    response to cold ISO
    Inferred from Sequence Orthology
    more info
     
    response to ethanol ISO
    Inferred from Sequence Orthology
    more info
     
    response to food IEA
    Inferred from Electronic Annotation
    more info
     
    response to food ISO
    Inferred from Sequence Orthology
    more info
     
    response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    response to nicotine IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to nicotine ISO
    Inferred from Sequence Orthology
    more info
     
    sensory processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sensory processing IEA
    Inferred from Electronic Annotation
    more info
     
    sensory processing ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    synapse organization IEA
    Inferred from Electronic Annotation
    more info
     
    synapse organization ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic transmission, cholinergic IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic transmission, cholinergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    synaptic transmission, cholinergic ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    acetylcholine-gated channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acetylcholine-gated channel complex IEA
    Inferred from Electronic Annotation
    more info
     
    acetylcholine-gated channel complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acetylcholine-gated channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    acetylcholine-gated channel complex TAS
    Traceable Author Statement
    more info
    PubMed 
    apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    asymmetric synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axolemma IEA
    Inferred from Electronic Annotation
    more info
     
    axolemma ISO
    Inferred from Sequence Orthology
    more info
     
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendritic shaft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    neuronal acetylcholine receptor subunit alpha-7
    Names
    C holinergic receptor, nicotinic, alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha)
    bungarotoxin alpha
    cholinergic receptor, nicotinic, alpha 7 (neuronal)
    cholinergic receptor, nicotinic, alpha polypeptide 7
    neuronal nicotinic acetycholine receptor alpha 7
    nicotinic receptor alpha 7 subunit

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012832.3NP_036964.3  neuronal acetylcholine receptor subunit alpha-7 precursor

      See identical proteins and their annotated locations for NP_036964.3

      Status: PROVISIONAL

      Source sequence(s)
      AY574256
      UniProtKB/Swiss-Prot
      Q05941
      Related
      ENSRNOP00000073551.1, ENSRNOT00000082487.1
      Conserved Domains (3) summary
      TIGR00860
      Location:4490
      LIC; Cation transporter family protein
      pfam02931
      Location:26230
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:237486
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      123897341..124039263 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008759498.2XP_008757720.1  neuronal acetylcholine receptor subunit alpha-7 isoform X1

      See identical proteins and their annotated locations for XP_008757720.1

      UniProtKB/TrEMBL
      Q5UMH9
      Related
      ENSRNOP00000045255.4, ENSRNOT00000051883.4
      Conserved Domains (3) summary
      TIGR00860
      Location:4519
      LIC; Cation transporter family protein
      pfam02931
      Location:26259
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:266515
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      108976664..109097764 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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