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    Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24300, updated on 12-Mar-2017
    Symbol
    Cyp2b1provided by RGD
    Full Name
    cytochrome P450, family 2, subfamily b, polypeptide 1provided by RGD
    Primary source
    RGD:2466
    See related
    Ensembl:ENSRNOG00000033680
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cypbe; Cyp2b-1
    Summary
    phenobarbitol-inducible member of the p450 xenobiotic-inducible superfamily involved in hydroxylation of decanoic and other fatty acids [RGD, Feb 2006]
    Location:
    7q33
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (99142431..99183540)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 7 NC_005106.3 (99752108..99777546)

    Chromosome 7 - NC_005106.4Genomic Context describing neighboring genes Neighboring gene MTSS1, I-BAR domain containing Neighboring gene uncharacterized LOC102551419 Neighboring gene ubiquitin-conjugating enzyme E2 variant 1-like Neighboring gene ubiquitin-conjugating enzyme E2 variant 1 pseudogene Neighboring gene uncharacterized LOC102551151

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC188065

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    arachidonic acid epoxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    aromatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    heme binding IEA
    Inferred from Electronic Annotation
    more info
     
    iron ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IEA
    Inferred from Electronic Annotation
    more info
     
    steroid hydroxylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    drug metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    epoxygenase P450 pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    response to calcium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to insulin IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to metal ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to sulfur dioxide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    organelle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    cytochrome P450 2B1
    Names
    CYPIIB1
    Cytochrome P450, subfamily IIB (phenobarbital-inducible) (b, e)
    P450-B
    P450-LM2
    P450-PB1 and P450-PB2
    P450b
    cytochrome P450-B
    cytochrome P450-LM2
    cytochrome P450-PB1
    cytochrome P450-PB2
    cytochrome P450b
    NP_001128316.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134844.1NP_001128316.1  cytochrome P450 2B1 precursor

      See identical proteins and their annotated locations for NP_001128316.1

      Status: PROVISIONAL

      Source sequence(s)
      BC166502
      UniProtKB/TrEMBL
      B2GV28
      Conserved Domains (1) summary
      pfam00067
      Location:48488
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005106.4 Reference Rnor_6.0 Primary Assembly

      Range
      99142431..99183540
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008765491.1XP_008763713.1  cytochrome P450 2B1 isoform X1

      UniProtKB/TrEMBL
      A0A140UHW7
      Conserved Domains (1) summary
      pfam00067
      Location:48496
      p450; Cytochrome P450
    2. XM_017594657.1XP_017450146.1  cytochrome P450 2B1 isoform X1

      UniProtKB/TrEMBL
      A0A140UHW7
      Related
      ENSRNOP00000049925, ENSRNOT00000044127
      Conserved Domains (1) summary
      pfam00067
      Location:48496
      p450; Cytochrome P450
    3. XM_008765492.1XP_008763714.1  cytochrome P450 2B1 isoform X2

      See identical proteins and their annotated locations for XP_008763714.1

      UniProtKB/TrEMBL
      B2GV28
      Conserved Domains (1) summary
      pfam00067
      Location:48488
      p450; Cytochrome P450
    4. XM_008765493.1XP_008763715.1  cytochrome P450 2B1 isoform X3

      Conserved Domains (1) summary
      pfam00067
      Location:8448
      p450; Cytochrome P450
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