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    Ctnnb1 catenin (cadherin associated protein), beta 1 [ Mus musculus (house mouse) ]

    Gene ID: 12387, updated on 28-Mar-2017
    Official Symbol
    Ctnnb1provided by MGI
    Official Full Name
    catenin (cadherin associated protein), beta 1provided by MGI
    Primary source
    MGI:MGI:88276
    See related
    Ensembl:ENSMUSG00000006932 Vega:OTTMUSG00000016490
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bfc; Mesc; Catnb
    Summary
    This gene encodes not only an important cytoplasmic component of the classical cadherin adhesion complex that forms the adherens junction in epithelia and mediates cell-cell adhesion in many other tissues but also a key signaling molecule in the canonical Wnt signaling pathway that controls cell growth and differentiation during both normal development and tumorigenesis. The gene product contains a central armadillo-repeat containing domain through which it binds the cytoplasmic tail of classical cadherins; meanwhile, it also binds alpha-catenin, which further links the cadherin complex to the actin cytoskeleton either directly or indirectly. Beta-catenin is therefore necessary for the adhesive function of classical cadherins. Another key function of this protein is to mediate the canonical Wnt signaling pathway and regulate gene transcription. Without Wnt signal, cytoplasmic beta-catenin that is not associated with the cadherin complex is quickly phosphorylated at the N-terminal Ser/Thr residues by the so called degradation complex containing axin, adenomatous polyposis coli (APC), casein kinase I, and GSK3B, then ubiquitylated by beta-TrCP, and degraded by the proteasome. However, in the presence of Wnt signal, the degradation complex is disrupted and the stabilized cytoplasmic beta-catenin translocates into the nucleus, where it binds various transcription factors and, together with these factors, regulates the transcription of many downstream genes. Mutations of this gene have been linked with various types of tumors. Alternatively spliced variants have been found for this gene. [provided by RefSeq, Sep 2009]
    Orthologs
    Location:
    9 F4; 9 72.19 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (120933400..120960507)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (120842518..120869625)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700020M21 gene Neighboring gene RIKEN cDNA 4930593C16 gene Neighboring gene predicted gene, 38502 Neighboring gene microRNA 7090 Neighboring gene unc-51-like kinase 4 Neighboring gene predicted gene, 34945 Neighboring gene zinc finger protein 606 pseudogene

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    I-SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II activating transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II core promoter proximal region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II core promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    alpha-catenin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    alpha-catenin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    alpha-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    cadherin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    cadherin binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin binding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    disordered domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone methyltransferase binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    ion channel binding ISO
    Inferred from Sequence Orthology
    more info
     
    ionotropic glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    nitric-oxide synthase binding ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear hormone receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    nuclear hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    repressing transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    signal transducer activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor activity, sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription regulatory region DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    Schwann cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    T cell differentiation in thymus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    adherens junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    adherens junction organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    animal organ development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    anterior/posterior axis specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    bone resorption IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    bone resorption IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    branching involved in blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    branching involved in ureteric bud morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    canonical Wnt signaling pathway involved in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac muscle cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    cardiac vascular smooth muscle cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell fate determination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell maturation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell morphogenesis involved in differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to indole-3-methanol ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to insulin-like growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to mechanical stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    central nervous system vasculogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chromatin-mediated maintenance of transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    coronary artery morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    cranial ganglion development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cranial skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dorsal root ganglion development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dorsal/ventral axis specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ectoderm development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic axis specification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    embryonic brain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic digit morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    embryonic digit morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic foregut morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic forelimb morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    embryonic heart tube development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic hindlimb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic skeletal limb joint morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    endoderm formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endodermal cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endothelial tube morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    epicardium-derived cardiac vascular smooth muscle cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    epithelial cell differentiation involved in prostate gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epithelial tube branching involved in lung morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    forebrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fungiform papilla formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    gastrulation with mouth forming second IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    genitalia morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glial cell fate determination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hair cycle process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hair follicle morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hair follicle placode formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    hair follicle placode formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hemopoiesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hindbrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    in utero embryonic development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    layer formation in cerebral cortex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lens morphogenesis in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    limb development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lung cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lung induction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lung-associated mesenchyme development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    male genitalia development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mesenchymal cell proliferation involved in lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mesenchyme development TAS
    Traceable Author Statement
    more info
    PubMed 
    mesenchyme morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    metanephros morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    midbrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    midbrain dopaminergic neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    morphogenesis of embryonic epithelium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of chondrocyte differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of mitotic cell cycle, embryonic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuron death IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of oligodendrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of oxidative stress-induced neuron death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    nephron tubule formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    neural plate development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    odontogenesis of dentin-containing tooth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oocyte development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oviduct development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pancreas development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of DNA-templated transcription, initiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of MAPK cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of branching involved in lung morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of chromatin-mediated maintenance of transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of core promoter binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of core promoter binding ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of determination of dorsal identity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of endothelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of epithelial cell proliferation involved in prostate gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of epithelial to mesenchymal transition TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of fibroblast growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of heparan sulfate proteoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mesenchymal cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuroblast proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of neuroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of sequence-specific DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of sequence-specific DNA binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of skeletal muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of telomerase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of telomere maintenance via telomerase IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    protein heterooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    proximal/distal pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of calcium ion import ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of centriole-centriole cohesion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of centromeric sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of centromeric sister chromatid cohesion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of chromatin-mediated maintenance of transcription NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of core promoter binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of euchromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of histone H3-K4 methylation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of histone H3-K4 methylation TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of histone demethylase activity (H3-K4 specific) TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of myelination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of nephron tubule epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of secondary heart field cardioblast proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    renal inner medulla development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    renal outer medulla development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    renal system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    renal vesicle formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to cytokine ISO
    Inferred from Sequence Orthology
    more info
     
    response to estradiol ISO
    Inferred from Sequence Orthology
    more info
     
    response to estrogen ISO
    Inferred from Sequence Orthology
    more info
     
    single organismal cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    single organismal cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    skin development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    smooth muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    stem cell population maintenance TAS
    Traceable Author Statement
    more info
    PubMed 
    sympathetic ganglion development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    synaptic vesicle transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    thymus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    trachea formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    trachea morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vasculogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ventricular compact myocardium morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    Scrib-APC-beta-catenin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Wnt signalosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Z disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    apical junction complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    beta-catenin destruction complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    beta-catenin destruction complex ISO
    Inferred from Sequence Orthology
    more info
     
    beta-catenin-TCF complex IC
    Inferred by Curator
    more info
    PubMed 
    beta-catenin-TCF complex ISO
    Inferred from Sequence Orthology
    more info
     
    beta-catenin-TCF7L2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    bicellular tight junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    catenin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    catenin complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    catenin complex ISO
    Inferred from Sequence Orthology
    more info
     
    catenin-TCF7L2 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    cell periphery ISO
    Inferred from Sequence Orthology
    more info
     
    cell projection membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic shaft ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    fascia adherens IDA
    Inferred from Direct Assay
    more info
    PubMed 
    flotillin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    intercalated disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular ISO
    Inferred from Sequence Orthology
    more info
     
    lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    microvillus membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear euchromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear euchromatin ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear transcription factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein-DNA complex ISO
    Inferred from Sequence Orthology
    more info
     
    synapse ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    catenin beta-1
    Names
    beta-catenin

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001165902.1NP_001159374.1  catenin beta-1

      See identical proteins and their annotated locations for NP_001159374.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC145731, BC048153
      Consensus CDS
      CCDS23630.1
      UniProtKB/Swiss-Prot
      Q02248
      Related
      ENSMUSP00000136294, OTTMUSP00000079042, ENSMUST00000178812, OTTMUST00000152499
      Conserved Domains (3) summary
      smart00185
      Location:350390
      ARM; Armadillo/beta-catenin-like repeats
      cd00020
      Location:399518
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:402427
      ARM; armadillo repeat [structural motif]
    2. NM_007614.3NP_031640.1  catenin beta-1

      See identical proteins and their annotated locations for NP_031640.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC053065, BY766878
      Consensus CDS
      CCDS23630.1
      UniProtKB/Swiss-Prot
      Q02248
      Related
      ENSMUSP00000007130, OTTMUSP00000017750, ENSMUST00000007130, OTTMUST00000039790
      Conserved Domains (3) summary
      smart00185
      Location:350390
      ARM; Armadillo/beta-catenin-like repeats
      cd00020
      Location:399518
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:402427
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      120933400..120960507
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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