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    CRTAC1 cartilage acidic protein 1 [ Homo sapiens (human) ]

    Gene ID: 55118, updated on 8-May-2017
    Official Symbol
    CRTAC1provided by HGNC
    Official Full Name
    cartilage acidic protein 1provided by HGNC
    Primary source
    HGNC:HGNC:14882
    See related
    Ensembl:ENSG00000095713 MIM:606276; Vega:OTTHUMG00000018871
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ASPIC; ASPIC1; CEP-68
    Summary
    This gene encodes a glycosylated extracellular matrix protein that is found in the interterritorial matrix of articular deep zone cartilage. This protein is used as a marker to distinguish chondrocytes from osteoblasts and mesenchymal stem cells in culture. The presence of FG-GAP motifs and an RGD integrin-binding motif suggests that this protein may be involved in cell-cell or cell-matrix interactions. Copy number alterations in this gene have been observed in neurofibromatosis type 1-associated glomus tumors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
    Orthologs
    Location:
    10q24.2
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 10 NC_000010.11 (97854711..98030828, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (99624757..99790585, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene secreted frizzled related protein 5 Neighboring gene uncharacterized LOC107984260 Neighboring gene long intergenic non-protein coding RNA 866 Neighboring gene golgin A7 family member B Neighboring gene R3H domain and coiled-coil containing 1 like Neighboring gene lysyl oxidase like 4

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ10320

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    axonal fasciculation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    olfactory bulb development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    growth cone IEA
    Inferred from Electronic Annotation
    more info
     
    proteinaceous extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    cartilage acidic protein 1
    Names
    acidic secreted protein in cartilage
    chondrocyte expressed protein 68 kDa CEP-68

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029831.1 RefSeqGene

      Range
      5001..170829
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001206528.2NP_001193457.1  cartilage acidic protein 1 isoform B precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as CRTAC1-B) includes alternate exon structure at its 3' end, and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (B) has a shorter and distinct C-terminus, compared to isoform A. This variant is supported by data in PMID:17074475.
      Source sequence(s)
      AJ421515, AK057190, R60584
      Consensus CDS
      CCDS55723.1
      UniProtKB/Swiss-Prot
      Q9NQ79
      Related
      ENSP00000359623.2, ENST00000370591.6
      Conserved Domains (3) summary
      pfam07593
      Location:460518
      UnbV_ASPIC; ASPIC and UnbV
      pfam07645
      Location:559605
      EGF_CA; Calcium-binding EGF domain
      pfam13517
      Location:299363
      VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
    2. NM_018058.6NP_060528.3  cartilage acidic protein 1 isoform A precursor

      See identical proteins and their annotated locations for NP_060528.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also known as CRTAC1-A) represents the longer transcript and encodes the longer isoform (A).
      Source sequence(s)
      AA485276, AJ276171, AK057190
      Consensus CDS
      CCDS31266.1
      UniProtKB/Swiss-Prot
      Q9NQ79
      Related
      ENSP00000359629.3, OTTHUMP00000020233, ENST00000370597.7, OTTHUMT00000049754
      Conserved Domains (3) summary
      pfam07593
      Location:460518
      UnbV_ASPIC; ASPIC and UnbV
      pfam07645
      Location:559605
      EGF_CA; Calcium-binding EGF domain
      pfam13517
      Location:299363
      VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p7 Primary Assembly

      Range
      97854711..98030828 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011539917.1XP_011538219.1  cartilage acidic protein 1 isoform X2

      Conserved Domains (3) summary
      pfam07593
      Location:460518
      UnbV_ASPIC; ASPIC and UnbV
      pfam07645
      Location:559605
      EGF_CA; Calcium-binding EGF domain
      pfam13517
      Location:299363
      VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
    2. XM_017016367.1XP_016871856.1  cartilage acidic protein 1 isoform X4

    3. XM_017016366.1XP_016871855.1  cartilage acidic protein 1 isoform X1

    4. XM_005269938.4XP_005269995.1  cartilage acidic protein 1 isoform X3

      Conserved Domains (3) summary
      pfam07593
      Location:460518
      UnbV_ASPIC; ASPIC and UnbV
      pfam07645
      Location:559605
      EGF_CA; Calcium-binding EGF domain
      pfam13517
      Location:299363
      VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella

    Alternate CHM1_1.1

    Genomic

    1. NC_018921.2 Alternate CHM1_1.1

      Range
      99906455..100072353 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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