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    IL5 interleukin 5 [ Homo sapiens (human) ]

    Gene ID: 3567, updated on 25-May-2017
    Official Symbol
    IL5provided by HGNC
    Official Full Name
    interleukin 5provided by HGNC
    Primary source
    HGNC:HGNC:6016
    See related
    Ensembl:ENSG00000113525 MIM:147850; Vega:OTTHUMG00000059496
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EDF; TRF; IL-5
    Summary
    This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2013]
    Orthologs
    Location:
    5q31.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 5 NC_000005.10 (132539194..132556827, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (131877136..131892555, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene chromosome 5 open reading frame 56 Neighboring gene uncharacterized LOC105379175 Neighboring gene interferon regulatory factor 1 Neighboring gene RAD50 double strand break repair protein Neighboring gene T helper type 2 locus control region associated RNA Neighboring gene interleukin 13

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    NHGRI GWA Catalog
    Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction.
    NHGRI GWA Catalog
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    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
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    • SOS-mediated signalling, organism-specific biosystem (from REACTOME)
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    • Signal Transduction, organism-specific biosystem (from REACTOME)
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    • Signaling by VEGF, organism-specific biosystem (from REACTOME)
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    • Signalling by NGF, organism-specific biosystem (from REACTOME)
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    • Signalling to ERKs, organism-specific biosystem (from REACTOME)
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    • Signalling to RAS, organism-specific biosystem (from REACTOME)
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    • Signalling to p38 via RIT and RIN, organism-specific biosystem (from REACTOME)
      Signalling to p38 via RIT and RIN, organism-specific biosystemRIT and RIN are two small guanine nucleotide binding proteins that share more than 50% sequence identity with RAS, including highly conserved core effector domains. Unlike RAS, the C termini of RIT a...
    • T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
      T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • T cell receptor signaling pathway, conserved biosystem (from KEGG)
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    • T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection, organism-specific biosystem (from WikiPathways)
      T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection, organism-specific biosystemThis pathway is based on Figure 4 of "A Model of an Integrated Immune System Pathway in Homo sapiens and Its Interaction with Superantigen Producing Expression Regulatory Pathway in Staphylococcus au...
    • Th1 and Th2 cell differentiation, organism-specific biosystem (from KEGG)
      Th1 and Th2 cell differentiation, organism-specific biosystemImmunity to different classes of microorganisms is orchestrated by separate lineages of effector T helper (TH)-cells, which differentiate from naive CD4+ precursor cells in response to cues provided ...
    • Th1 and Th2 cell differentiation, conserved biosystem (from KEGG)
      Th1 and Th2 cell differentiation, conserved biosystemImmunity to different classes of microorganisms is orchestrated by separate lineages of effector T helper (TH)-cells, which differentiate from naive CD4+ precursor cells in response to cues provided ...
    • VEGFA-VEGFR2 Pathway, organism-specific biosystem (from REACTOME)
      VEGFA-VEGFR2 Pathway, organism-specific biosystemAngiogenesis is the formation of new blood vessels from preexisting vasculature. One of the most important proangiogenic factors is vascular endothelial growth factor (VEGF). VEGF exerts its biologic...
    • VEGFR2 mediated cell proliferation, organism-specific biosystem (from REACTOME)
      VEGFR2 mediated cell proliferation, organism-specific biosystemVEGFR2 stimulates ERK not via GRB2-SOS-RAS, but via pY1175-dependent phosphorylation of PLC gamma and subsequent activation of PKCs. PKC plays an important mediatory role in the proliferative Ras/Raf...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    Ras guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
     
    cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    interleukin-5 receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    MAPK cascade TAS
    Traceable Author Statement
    more info
     
    cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    immune response IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of B cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of JAK-STAT cascade IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of eosinophil differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of immunoglobulin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of podosome assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of sequence-specific DNA binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space TAS
    Traceable Author Statement
    more info
    PubMed 
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    interleukin-5
    Names
    B-cell differentiation factor I
    T-cell replacing factor
    colony-stimulating factor, eosinophil
    eosinophil differentiation factor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033019.1 RefSeqGene

      Range
      5001..7079
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000879.2NP_000870.1  interleukin-5 precursor

      See identical proteins and their annotated locations for NP_000870.1

      Status: REVIEWED

      Source sequence(s)
      X04688
      Consensus CDS
      CCDS4156.1
      UniProtKB/Swiss-Prot
      P05113
      Related
      ENSP00000231454.1, OTTHUMP00000065830, ENST00000231454.5, OTTHUMT00000132339
      Conserved Domains (1) summary
      pfam02025
      Location:22133
      IL5; Interleukin 5

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p7 Primary Assembly

      Range
      132539194..132556827 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005271988.3XP_005272045.1  interleukin-5 isoform X1

      Conserved Domains (1) summary
      pfam02025
      Location:44155
      IL5; Interleukin 5
    2. XM_011543374.2XP_011541676.1  interleukin-5 isoform X2

      See identical proteins and their annotated locations for XP_011541676.1

      UniProtKB/Swiss-Prot
      P05113
      Conserved Domains (1) summary
      pfam02025
      Location:22133
      IL5; Interleukin 5
    3. XM_011543373.2XP_011541675.1  interleukin-5 isoform X2

      See identical proteins and their annotated locations for XP_011541675.1

      UniProtKB/Swiss-Prot
      P05113
      Conserved Domains (1) summary
      pfam02025
      Location:22133
      IL5; Interleukin 5

    Alternate CHM1_1.1

    Genomic

    1. NC_018916.2 Alternate CHM1_1.1

      Range
      131310410..131312488 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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