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    Txnrd1 thioredoxin reductase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 58819, updated on 5-Nov-2017
    Official Symbol
    Txnrd1provided by RGD
    Official Full Name
    thioredoxin reductase 1provided by RGD
    Primary source
    RGD:61959
    See related
    Ensembl:ENSRNOG00000009088
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tr
    Summary
    The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms. [provided by RefSeq, Jun 2017]
    Orthologs
    Location:
    7q13
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (26946124..26984400, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 7 NC_005106.3 (27065819..27104095, complement)

    Chromosome 7 - NC_005106.4Genomic Context describing neighboring genes Neighboring gene vegetative cell wall protein gp1-like Neighboring gene solute carrier family 41 member 2 Neighboring gene carbohydrate sulfotransferase 11 Neighboring gene uncharacterized LOC103692813 Neighboring gene uncharacterized LOC108351425 Neighboring gene EP300 interacting inhibitor of differentiation 3 Neighboring gene uncharacterized LOC103692815

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC93353

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NAD(P)H oxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    electron transfer activity IEA
    Inferred from Electronic Annotation
    more info
     
    flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    mercury ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    selenate reductase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    thioredoxin-disulfide reductase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    thioredoxin-disulfide reductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    thioredoxin-disulfide reductase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    NADPH oxidation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    benzene-containing compound metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell redox homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cell redox homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to copper ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to hyperoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    gastrulation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    halogen metabolic process IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    hydrogen peroxide catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mesoderm formation IEA
    Inferred from Electronic Annotation
    more info
     
    mesoderm formation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    placenta development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    positive regulation of cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein tetramerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to axon injury IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to hyperoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to oxygen radical IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    response to selenium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    selenocysteine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cell IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    fibrillar center IEA
    Inferred from Electronic Annotation
    more info
     
    fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Preferred Names
    thioredoxin reductase 1, cytoplasmic
    Names
    NADPH-dependent thioredoxin reductase
    selenoprotein oxidoreductase
    thioredoxin reductase TR1
    NP_113802.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001351981.1NP_001338910.1  thioredoxin reductase 1, cytoplasmic isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks a 5' non-coding exon; therefore, has a shorter 5' UTR compared to variant 1. Variants 1-3 encode the same isoform (1).
      Source sequence(s)
      AF220761, BC085726, BF415095, CB579100
      Conserved Domains (1) summary
      TIGR01438
      Location:11499
      TGR; thioredoxin and glutathione reductase selenoprotein
    2. NM_001351983.1NP_001338912.1  thioredoxin reductase 1, cytoplasmic isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same isoform (1).
      Source sequence(s)
      BC085726, BF415095, FQ090798, FQ225805
      Conserved Domains (1) summary
      TIGR01438
      Location:11499
      TGR; thioredoxin and glutathione reductase selenoprotein
    3. NM_001351984.1NP_001338913.1  thioredoxin reductase 1, cytoplasmic isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents use of an alternate upstream promoter, and contains additional exons at the 5' end compared to variant 1. The encoded isoform (2) has a longer and distinct N-terminus, resulting from translation initiation at an in-frame upstream start codon, compared to isoform 1.
      Source sequence(s)
      BC085726, BF415095
      Conserved Domains (1) summary
      TIGR01438
      Location:92580
      TGR; thioredoxin and glutathione reductase selenoprotein
    4. NM_031614.3NP_113802.2  thioredoxin reductase 1, cytoplasmic isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1. Variants 1-3 encode the same isoform.
      Source sequence(s)
      BC085726, BF415095, CB579100
      Related
      ENSRNOP00000013612.7, ENSRNOT00000013613.7
      Conserved Domains (1) summary
      TIGR01438
      Location:11499
      TGR; thioredoxin and glutathione reductase selenoprotein

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005106.4 Reference Rnor_6.0 Primary Assembly

      Range
      26946124..26984400 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000075.1 Alternate Rn_Celera

      Range
      18009974..18048177 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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