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    FOXO1 forkhead box O1 [ Bos taurus (cattle) ]

    Gene ID: 506618, updated on 31-Oct-2016
    Gene symbol
    FOXO1
    Gene description
    forkhead box O1
    See related
    BGD:BT10280
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    FOXO1A
    Orthologs
    Location:
    chromosome: 12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    105 current Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 12 AC_000169.1 (21915296..22009081)

    Chromosome 12 - AC_000169.1Genomic Context describing neighboring genes Neighboring gene testis-specific Y-encoded-like protein 5 Neighboring gene mitochondrial ribosomal protein S31 Neighboring gene component of oligomeric golgi complex 6 Neighboring gene lipoma HMGIC fusion partner

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    beta-catenin binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphatase 2A binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transcription factor activity, transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    blood vessel development IEA
    Inferred from Electronic Annotation
    more info
     
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to hyperoxia ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to insulin stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to nitric oxide ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to oxidative stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to starvation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of stress-activated MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal stem cell population maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of autophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of neural precursor cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of reactive oxygen species metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    forkhead box protein O1
    Names
    forkhead box protein O1A
    forkhead in rhabdomyosarcoma

    RefSeqs of Annotated Genomes: Bos taurus Annotation Release 105 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Bos_taurus_UMD_3.1.1 Primary Assembly

    Genomic

    1. AC_000169.1 Reference Bos_taurus_UMD_3.1.1 Primary Assembly

      Range
      21915296..22009081
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015473787.1XP_015329273.1  

      Conserved Domains (3) summary
      cd00059
      Location:121201
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
      pfam16675
      Location:384460
      FOXO_KIX_bdg; KIX-binding domain of forkhead box O, CR2
      pfam16676
      Location:557593
      FOXO-TAD; Transactivation domain of FOXO protein family

    Alternate Btau_5.0.1

    Genomic

    1. NC_007310.6 Alternate Btau_5.0.1

      Range
      21991463..22086208
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015465638.1XP_015321124.1  

      Conserved Domains (3) summary
      cd00059
      Location:172252
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
      pfam16675
      Location:435511
      FOXO_KIX_bdg; KIX-binding domain of forkhead box O, CR2
      pfam16676
      Location:608644
      FOXO-TAD; Transactivation domain of FOXO protein family
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