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    FUS FUS RNA binding protein [ Homo sapiens (human) ]

    Gene ID: 2521, updated on 6-Dec-2016
    Official Symbol
    FUSprovided by HGNC
    Official Full Name
    FUS RNA binding proteinprovided by HGNC
    Primary source
    HGNC:HGNC:4010
    See related
    Ensembl:ENSG00000089280 MIM:137070; Vega:OTTHUMG00000132395
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TLS; ALS6; ETM4; FUS1; POMP75; HNRNPP2
    Summary
    This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009]
    Orthologs
    Location:
    16p11.2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 16 NC_000016.10 (31179444..31194871)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (31191431..31206192)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene protease, serine 36 Neighboring gene NADH:ubiquinone oxidoreductase subunit A3 pseudogene 6 Neighboring gene PYCARD antisense RNA 1 Neighboring gene PYD and CARD domain containing Neighboring gene tripartite motif containing 72 Neighboring gene pyrin domain containing 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev interacting protein, FUS (fused in sarcoma; HNRNPP2), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with FUS is increased by RRE PubMed
    Tat tat FUS RNA binding protein (FUS) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS PubMed

    Go to the HIV-1, Human Interaction Database

    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
      Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
    • Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
      Transcriptional misregulation in cancer, organism-specific biosystem
      Transcriptional misregulation in cancer
    • Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
      Transcriptional misregulation in cancer, conserved biosystem
      Transcriptional misregulation in cancer
    • mRNA Processing, organism-specific biosystem (from WikiPathways)
      mRNA Processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...
    • mRNA Splicing, organism-specific biosystem (from REACTOME)
      mRNA Splicing, organism-specific biosystemThe process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing...
    • mRNA Splicing - Major Pathway, organism-specific biosystem (from REACTOME)
      mRNA Splicing - Major Pathway, organism-specific biosystemThe splicing of pre-mRNA occurs within a large, very dynamic complex, designated the 'spliceosome'. The 50-60S spliceosomes are estimated to be 40-60 nm in diameter, and have molecular weights in the...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    estrogen receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ionotropic glutamate receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    myosin V binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    poly(A) RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    retinoid X receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    thyroid hormone receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cellular response to calcium ion IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA splicing, via spliceosome TAS
    Traceable Author Statement
    more info
     
    regulation of nucleic acid-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    dendritic spine head IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    polysome IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    RNA-binding protein FUS
    Names
    75 kDa DNA-pairing protein
    fus-like protein
    fused in sarcoma
    fusion gene in myxoid liposarcoma
    heterogeneous nuclear ribonucleoprotein P2
    oncogene FUS
    oncogene TLS
    translocated in liposarcoma protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012889.2 RefSeqGene

      Range
      4979..19740
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_655

    mRNA and Protein(s)

    1. NM_001170634.1NP_001164105.1  RNA-binding protein FUS isoform 2

      See identical proteins and their annotated locations for NP_001164105.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a shorter isoform (2), compared to isoform 1.
      Source sequence(s)
      AC009088, AI333366, DC361263
      Consensus CDS
      CCDS58454.1
      UniProtKB/Swiss-Prot
      P35637
      Related
      ENSP00000369594, OTTHUMP00000255007, ENST00000380244, OTTHUMT00000433551
      Conserved Domains (3) summary
      COG0724
      Location:263373
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12535
      Location:282367
      RRM_FUS_TAF15; RNA recognition motif in vertebrate fused in Ewing's sarcoma protein (FUS), TATA-binding protein-associated factor 15 (TAF15) and similar proteins
      pfam00641
      Location:421448
      zf-RanBP; Zn-finger in Ran binding protein and others
    2. NM_001170937.1NP_001164408.1  RNA-binding protein FUS isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
      Source sequence(s)
      AC009088, AI333366, DA541747, DC361263, U36561
      UniProtKB/TrEMBL
      Q13344
      Conserved Domains (3) summary
      COG0724
      Location:260370
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12535
      Location:279364
      RRM_FUS_TAF15; RNA recognition motif in vertebrate fused in Ewing's sarcoma protein (FUS), TATA-binding protein-associated factor 15 (TAF15) and similar proteins
      pfam00641
      Location:418445
      zf-RanBP; Zn-finger in Ran binding protein and others
    3. NM_004960.3NP_004951.1  RNA-binding protein FUS isoform 1

      See identical proteins and their annotated locations for NP_004951.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC009088, AI333366, AW408771, BC002459, DC361263
      Consensus CDS
      CCDS10707.1
      UniProtKB/Swiss-Prot
      P35637
      UniProtKB/TrEMBL
      Q6IBQ5
      Related
      ENSP00000254108, OTTHUMP00000163228, ENST00000254108, OTTHUMT00000255526
      Conserved Domains (3) summary
      COG0724
      Location:264374
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12535
      Location:283368
      RRM_FUS_TAF15; RNA recognition motif in vertebrate fused in Ewing's sarcoma protein (FUS), TATA-binding protein-associated factor 15 (TAF15) and similar proteins
      pfam00641
      Location:422449
      zf-RanBP; Zn-finger in Ran binding protein and others

    RNA

    1. NR_028388.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) omits an exon in the coding sequence, compared to variant 1, resulting in a frameshift and premature stop codon. The transcript is predicted to be subject to nonsense-mediated decay and thus the truncated protein is not annotated.
      Source sequence(s)
      AC009088, AI333366, AW408771, DC361263

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p7 Primary Assembly

      Range
      31179444..31194871
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005255233.4XP_005255290.1  

      See identical proteins and their annotated locations for XP_005255290.1

      Conserved Domains (3) summary
      COG0724
      Location:63169
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12535
      Location:78163
      RRM_FUS_TAF15; RNA recognition motif in vertebrate fused in Ewing's sarcoma protein (FUS), TATA-binding protein-associated factor 15 (TAF15) and similar proteins
      pfam00641
      Location:217244
      zf-RanBP; Zn-finger in Ran binding protein and others
    2. XM_011545781.1XP_011544083.1  

      Related
      ENSP00000455282, OTTHUMP00000255009, ENST00000568685, OTTHUMT00000433552
      Conserved Domains (3) summary
      COG0724
      Location:262372
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12535
      Location:281366
      RRM_FUS_TAF15; RNA recognition motif in vertebrate fused in Ewing's sarcoma protein (FUS), TATA-binding protein-associated factor 15 (TAF15) and similar proteins
      pfam00641
      Location:420447
      zf-RanBP; Zn-finger in Ran binding protein and others
    3. XM_011545782.2XP_011544084.1  

      See identical proteins and their annotated locations for XP_011544084.1

      Conserved Domains (3) summary
      COG0724
      Location:63169
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12535
      Location:78163
      RRM_FUS_TAF15; RNA recognition motif in vertebrate fused in Ewing's sarcoma protein (FUS), TATA-binding protein-associated factor 15 (TAF15) and similar proteins
      pfam00641
      Location:217244
      zf-RanBP; Zn-finger in Ran binding protein and others

    Alternate CHM1_1.1

    Genomic

    1. NC_018927.2 Alternate CHM1_1.1

      Range
      32509148..32523909
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001010850.1: Suppressed sequence

      Description
      NM_001010850.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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