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    Map3k7 mitogen-activated protein kinase kinase kinase 7 [ Mus musculus (house mouse) ]

    Gene ID: 26409, updated on 19-Nov-2017
    Official Symbol
    Map3k7provided by MGI
    Official Full Name
    mitogen-activated protein kinase kinase kinase 7provided by MGI
    Primary source
    MGI:MGI:1346877
    See related
    Ensembl:ENSMUSG00000028284 Vega:OTTMUSG00000004905
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tak1; C87327; B430101B05
    Orthologs
    Location:
    4; 4 A5
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (31963395..32023470)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (32051082..32110442)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 42265 Neighboring gene predicted gene, 32412 Neighboring gene predicted gene 11927 Neighboring gene predicted gene, 42266

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    MAP kinase kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    MAP kinase kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    I-kappaB phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    activation of MAPKK activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    anoikis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of necroptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of ripoptosome assembly involved in necroptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neural tube formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of JNK cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    mitogen-activated protein kinase kinase kinase 7
    Names
    TGF-beta-activated kinase 1
    transforming growth factor-beta-activated kinase 1
    NP_033342.1
    NP_766276.1
    XP_006538011.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009316.1NP_033342.1  mitogen-activated protein kinase kinase kinase 7 isoform B

      See identical proteins and their annotated locations for NP_033342.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (B) represents the longer transcript and encodes the longer isoform (B).
      Source sequence(s)
      AK137046, AL833781, CV559615
      Consensus CDS
      CCDS51133.1
      UniProtKB/TrEMBL
      Q543B5, Q923A8
      Related
      ENSMUSP00000040307.4, OTTMUSP00000005099, ENSMUST00000037607.10, OTTMUST00000010919
      Conserved Domains (1) summary
      cd14058
      Location:42292
      STKc_TAK1; Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Activated Kinase-1
    2. NM_172688.3NP_766276.1  mitogen-activated protein kinase kinase kinase 7 isoform A

      See identical proteins and their annotated locations for NP_766276.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (A) lacks an in-frame coding segment, compared to variant B. The resulting isoform (A) lacks an internal region, as compared to isoform B.
      Source sequence(s)
      AK137046, AL833781
      Consensus CDS
      CCDS18014.1
      UniProtKB/Swiss-Prot
      Q62073
      UniProtKB/TrEMBL
      Q543B5
      Related
      ENSMUSP00000079734.6, OTTMUSP00000005100, ENSMUST00000080933.12, OTTMUST00000010920
      Conserved Domains (1) summary
      cd14058
      Location:42292
      STKc_TAK1; Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Activated Kinase-1

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      31963395..32023470
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006537948.3XP_006538011.1  mitogen-activated protein kinase kinase kinase 7 isoform X1

      Conserved Domains (1) summary
      cl21453
      Location:1162
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_390323.3 RNA Sequence

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