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    NTG1 bifunctional N-glycosylase/AP lyase NTG1 [ Saccharomyces cerevisiae S288c ]

    Gene ID: 851218, updated on 25-May-2017
    Gene symbol
    NTG1
    Gene description
    bifunctional N-glycosylase/AP lyase NTG1
    Primary source
    SGD:S000000013
    Locus tag
    YAL015C
    Gene type
    protein coding
    RNA name
    bifunctional N-glycosylase/AP lyase NTG1
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    FUN33; ogg2; SCR1
    See NTG1 in Map Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_001133.9 (126903..128102, complement)

    Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene serine/threonine protein kinase PSK1 Neighboring gene protein phosphatase 2A structural subunit TPD3 Neighboring gene syntaxin Neighboring gene Rpd3L histone deacetylase complex subunit DEP1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    DNA N-glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-(apurinic or apyrimidinic site) lyase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-(apurinic or apyrimidinic site) lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
     
    lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    oxidized purine nucleobase lesion DNA N-glycosylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA repair IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    base-excision repair IDA
    Inferred from Direct Assay
    more info
    PubMed 
    base-excision repair IEA
    Inferred from Electronic Annotation
    more info
     
    base-excision repair, AP site formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    base-excision repair, AP site formation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide-excision repair, DNA incision, 5'-to lesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of mitochondrial DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Names
    bifunctional N-glycosylase/AP lyase NTG1
    NP_009387.1
    • DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; required for maintaining mitochondrial genome integrity; NTG1 has a paralog, NTG2, that arose from the whole genome duplication

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001133.9 Reference assembly

      Range
      126903..128102 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178160.1NP_009387.1  TPA: bifunctional N-glycosylase/AP lyase NTG1 [Saccharomyces cerevisiae S288c]

      See identical proteins and their annotated locations for NP_009387.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P31378
      Conserved Domains (2) summary
      smart00478
      Location:152312
      ENDO3c; endonuclease III
      COG0177
      Location:140318
      Nth; Endonuclease III [Replication, recombination and repair]
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