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    Tph1 tryptophan hydroxylase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24848, updated on 22-Apr-2017
    Official Symbol
    Tph1provided by RGD
    Official Full Name
    tryptophan hydroxylase 1provided by RGD
    Primary source
    RGD:3895
    See related
    Ensembl:ENSRNOG00000011672
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tph
    Summary
    catalyzes the conversion of l-tryptophan to 5-hydroxy-l-tryptophan; member of pterin-dependent aromatic amino acid hydroxylase family [RGD, Feb 2006]
    Orthologs
    Location:
    1q22
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (102669868..102699442, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (103746878..103774100, complement)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel subfamily C member 1 Neighboring gene secretion regulating guanine nucleotide exchange factor Neighboring gene similar to Serum amyloid A-3 protein precursor Neighboring gene serum amyloid A-like 1

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    amino acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    iron ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    tryptophan 5-monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    tryptophan 5-monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    bone remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    bone remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    mammary gland alveolus development IEA
    Inferred from Electronic Annotation
    more info
     
    mammary gland alveolus development ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of ossification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    response to immobilization stress IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    serotonin biosynthetic process from tryptophan TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    tryptophan 5-hydroxylase 1
    Names
    tryptophan 5-monooxygenase 1
    NP_001094104.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100634.2NP_001094104.1  tryptophan 5-hydroxylase 1

      See identical proteins and their annotated locations for NP_001094104.1

      Status: VALIDATED

      Source sequence(s)
      AABR07003260, AABR07003262
      UniProtKB/Swiss-Prot
      P09810
      Related
      ENSRNOP00000052959.2, ENSRNOT00000056109.3
      Conserved Domains (3) summary
      TIGR01270
      Location:3439
      Trp_5_monoox; tryptophan 5-monooxygenase, tetrameric
      cd04929
      Location:1991
      ACT_TPH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tryptophan hydroxylases (TPH), both peripheral (TPH1) and neuronal (TPH2) enzymes
      pfam00351
      Location:106435
      Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      102669868..102699442 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006229219.2XP_006229281.1  tryptophan 5-hydroxylase 1 isoform X2

      See identical proteins and their annotated locations for XP_006229281.1

      UniProtKB/Swiss-Prot
      P09810
      Conserved Domains (3) summary
      TIGR01270
      Location:3439
      Trp_5_monoox; tryptophan 5-monooxygenase, tetrameric
      cd04929
      Location:1991
      ACT_TPH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tryptophan hydroxylases (TPH), both peripheral (TPH1) and neuronal (TPH2) enzymes
      pfam00351
      Location:106435
      Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase
    2. XM_006229218.3XP_006229280.1  tryptophan 5-hydroxylase 1 isoform X1

      Conserved Domains (3) summary
      TIGR01270
      Location:69505
      Trp_5_monoox; tryptophan 5-monooxygenase, tetrameric
      cd04929
      Location:85157
      ACT_TPH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tryptophan hydroxylases (TPH), both peripheral (TPH1) and neuronal (TPH2) enzymes
      pfam00351
      Location:172501
      Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      91404769..91425505 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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