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    Lat linker for activation of T cells [ Mus musculus (house mouse) ]

    Gene ID: 16797, updated on 25-May-2017
    Official Symbol
    Latprovided by MGI
    Official Full Name
    linker for activation of T cellsprovided by MGI
    Primary source
    MGI:MGI:1342293
    See related
    Ensembl:ENSMUSG00000030742 Vega:OTTMUSG00000058212
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    pp36; p36-38
    Orthologs
    Location:
    7; 7 F3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (126363827..126369588, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (133507341..133513048, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein L21 pseudogene Neighboring gene predicted gene, 30928 Neighboring gene microRNA 7058 Neighboring gene spinster homolog 1 Neighboring gene nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    SH3/SH2 adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    signal transducer activity, downstream of receptor TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    cellular defense response TAS
    Traceable Author Statement
    more info
    PubMed 
    gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    homeostasis of number of cells IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    immune response ISO
    Inferred from Sequence Orthology
    more info
     
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    lymphocyte homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mast cell degranulation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of T cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane receptor protein tyrosine kinase signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    COP9 signalosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    immunological synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    immunological synapse ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    linker for activation of T-cells family member 1
    Names
    36 kDa phospho-tyrosine adapter protein
    linker protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010689.3NP_034819.1  linker for activation of T-cells family member 1 precursor

      See identical proteins and their annotated locations for NP_034819.1

      Status: VALIDATED

      Source sequence(s)
      AC125322, AK134003, BE947351
      Consensus CDS
      CCDS21825.1
      UniProtKB/Swiss-Prot
      O54957
      UniProtKB/TrEMBL
      Q546H1
      Related
      ENSMUSP00000032997.6, OTTMUSP00000074541, ENSMUST00000032997.7, OTTMUST00000142943
      Conserved Domains (1) summary
      pfam15234
      Location:24242
      LAT; Linker for activation of T-cells

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      126363827..126369588 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507398.3XP_006507461.1  linker for activation of T-cells family member 1 isoform X3

      Conserved Domains (1) summary
      pfam15234
      Location:8180
      LAT; Linker for activation of T-cells
    2. XM_006507397.2XP_006507460.2  linker for activation of T-cells family member 1 isoform X2

      Conserved Domains (1) summary
      pfam15234
      Location:24228
      LAT; Linker for activation of T-cells
    3. XM_006507396.2XP_006507459.2  linker for activation of T-cells family member 1 isoform X1

      UniProtKB/TrEMBL
      A0A0U1RP03
      Related
      ENSMUSP00000145773.1, OTTMUSP00000074540, ENSMUST00000206793.1, OTTMUST00000142942
      Conserved Domains (1) summary
      pfam15234
      Location:24232
      LAT; Linker for activation of T-cells
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