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    FOXK2 forkhead box K2 [ Homo sapiens (human) ]

    Gene ID: 3607, updated on 25-May-2017
    Official Symbol
    FOXK2provided by HGNC
    Official Full Name
    forkhead box K2provided by HGNC
    Primary source
    HGNC:HGNC:6036
    See related
    Ensembl:ENSG00000141568 MIM:147685; Vega:OTTHUMG00000140374
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ILF; ILF1; ILF-1
    Summary
    The protein encoded by this gene contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) promoter. It may be involved in the regulation of viral and cellular promoter elements. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    17q25.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 17 NC_000017.11 (82519718..82604607)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (80477594..80562483)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene nuclear prelamin A recognition factor Neighboring gene transfer RNA-iMet (CAT) 1-8 Neighboring gene uncharacterized LOC105371942 Neighboring gene ADP ribosylation factor like GTPase 2 binding protein pseudogene 9 Neighboring gene WD repeat domain 45B Neighboring gene RAB40B, member RAS oncogene family Neighboring gene microRNA 4525

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Deubiquitination, organism-specific biosystem (from REACTOME)
      Deubiquitination, organism-specific biosystemUbiquitination, the modification of proteins by the covalent attachment of ubiquitin (Ub), is a key regulatory mechanism for many many cellular processes, including protein degradation by the 26S pro...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • UCH proteinases, organism-specific biosystem (from REACTOME)
      UCH proteinases, organism-specific biosystemDUBs of the Ub C-terminal Hydrolase (UCH) family are thiol proteases that have an N-terminal catalytic domain sometimes followed by C-terminal extensions that mediate protein-protein interactions. Hu...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Preferred Names
    forkhead box protein K2
    Names
    FOXK1
    cellular transcription factor ILF-1
    interleukin enhancer-binding factor 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004514.3NP_004505.2  forkhead box protein K2

      See identical proteins and their annotated locations for NP_004505.2

      Status: REVIEWED

      Source sequence(s)
      AC124283, AC124287, U58196
      Consensus CDS
      CCDS11813.1
      UniProtKB/Swiss-Prot
      Q01167
      Related
      ENSP00000335677.5, OTTHUMP00000179134, ENST00000335255.9, OTTHUMT00000277099
      Conserved Domains (3) summary
      COG5025
      Location:180577
      COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
      cd00060
      Location:47154
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam00250
      Location:258344
      Forkhead; Forkhead domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p7 Primary Assembly

      Range
      82519718..82604607
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001752506.1 RNA Sequence

    2. XR_933935.2 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      80541303..80648238
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_181430.1: Suppressed sequence

      Description
      NM_181430.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    2. NM_181431.1: Suppressed sequence

      Description
      NM_181431.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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