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    Lefty1 left right determination factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 13590, updated on 10-Oct-2017
    Official Symbol
    Lefty1provided by MGI
    Official Full Name
    left right determination factor 1provided by MGI
    Primary source
    MGI:MGI:107405
    See related
    Ensembl:ENSMUSG00000038793 Vega:OTTMUSG00000021473
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ebaf; Leftb; Stra3; Tgfb4; lefty; lefty-1; AI450052
    Summary
    This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. Mice lacking a functional copy of this gene exhibit embryonic lethality and defects in left-right patterning. [provided by RefSeq, Aug 2016]
    Location:
    1; 1 H4
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (180935039..180938401)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (182865170..182868532)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene pyrroline-5-carboxylate reductase family, member 2 Neighboring gene predicted gene, 32199 Neighboring gene predicted gene, 39715 Neighboring gene transmembrane protein 63a Neighboring gene epoxide hydrolase 1, microsomal

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    nodal binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transforming growth factor beta receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    SMAD protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    anterior/posterior axis specification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cell growth IEA
    Inferred from Electronic Annotation
    more info
     
    cell migration involved in gastrulation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    determination of left/right symmetry IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heart morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of nodal receptor complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of nodal signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of pathway-restricted SMAD protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    response to retinoic acid IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    left-right determination factor 1
    Names
    TGF-beta-4
    left-right determination, factor B
    protein lefty-1
    stimulated by retinoic acid gene 3 protein
    transforming growth factor beta-4

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010094.4NP_034224.1  left-right determination factor 1 preproprotein

      See identical proteins and their annotated locations for NP_034224.1

      Status: REVIEWED

      Source sequence(s)
      AA216877, AC117673, AK131943
      Consensus CDS
      CCDS15577.1
      UniProtKB/Swiss-Prot
      Q64280
      Related
      ENSMUSP00000041427.8, OTTMUSP00000023876, ENSMUST00000037361.8, OTTMUST00000050907
      Conserved Domains (2) summary
      pfam00019
      Location:263355
      TGF_beta; Transforming growth factor beta like domain
      pfam00688
      Location:106211
      TGFb_propeptide; TGF-beta propeptide

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      180935039..180938401
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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