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    COL2A1 collagen type II alpha 1 chain [ Equus caballus (horse) ]

    Gene ID: 791241, updated on 12-Mar-2017
    Gene symbol
    COL2A1
    Gene description
    collagen type II alpha 1 chain
    See related
    Ensembl:ENSECAG00000022313
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    Location:
    chromosome: 6
    Exon count:
    54
    Annotation release Status Assembly Chr Location
    102 current EquCab2.0 (GCF_000002305.2) 6 NC_009149.2 (65628784..65660156, complement)

    Chromosome 6 - NC_009149.2Genomic Context describing neighboring genes Neighboring gene vitamin D (1,25- dihydroxyvitamin D3) receptor Neighboring gene transmembrane protein 106C Neighboring gene SUMO1/sentrin specific peptidase 1 Neighboring gene phosphofructokinase, muscle

    Genomic Sequence:
    NC_009149.2 Chromosome 6 Reference EquCab2.0 Primary Assembly
    • ECM-receptor interaction, organism-specific biosystem (from KEGG)
      ECM-receptor interaction, organism-specific biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • ECM-receptor interaction, conserved biosystem (from KEGG)
      ECM-receptor interaction, conserved biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • Protein digestion and absorption, organism-specific biosystem (from KEGG)
      Protein digestion and absorption, organism-specific biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...
    • Protein digestion and absorption, conserved biosystem (from KEGG)
      Protein digestion and absorption, conserved biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...

    Markers

    Homology

    Preferred Names
    collagen alpha-1(II) chain
    Names
    collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital)
    type II collagen

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081764.1NP_001075233.1  collagen alpha-1(II) chain precursor

      See identical proteins and their annotated locations for NP_001075233.1

      Status: PROVISIONAL

      Source sequence(s)
      U62528
      UniProtKB/TrEMBL
      Q28396
      Related
      ENSECAP00000021299, ENSECAT00000025597
      Conserved Domains (2) summary
      pfam01391
      Location:732791
      Collagen; Collagen triple helix repeat (20 copies)
      pfam01410
      Location:11851417
      COLFI; Fibrillar collagen C-terminal domain

    RefSeqs of Annotated Genomes: Equus caballus Annotation Release 102 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab2.0 Primary Assembly

    Genomic

    1. NC_009149.2 Reference EquCab2.0 Primary Assembly

      Range
      65628784..65660156 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005611082.2XP_005611139.1  collagen alpha-1(II) chain isoform X1

      UniProtKB/TrEMBL
      F6Y8T1
      Related
      ENSECAP00000021294, ENSECAT00000025592
      Conserved Domains (3) summary
      pfam01391
      Location:801860
      Collagen; Collagen triple helix repeat (20 copies)
      pfam00093
      Location:3489
      VWC; von Willebrand factor type C domain
      pfam01410
      Location:12541486
      COLFI; Fibrillar collagen C-terminal domain
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