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    Gad2 glutamic acid decarboxylase 2 [ Mus musculus (house mouse) ]

    Gene ID: 14417, updated on 25-Apr-2017
    Official Symbol
    Gad2provided by MGI
    Official Full Name
    glutamic acid decarboxylase 2provided by MGI
    Primary source
    MGI:MGI:95634
    See related
    Ensembl:ENSMUSG00000026787 Vega:OTTMUSG00000011505
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GAD65; Gad-2; GAD(65); 6330404F12Rik
    Orthologs
    Location:
    2 A3; 2 15.15 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (22621422..22693877)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (22477847..22549397)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene 3-phosphoglycerate dehydrogenase pseudogene Neighboring gene myosin IIIA Neighboring gene guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 pseudogene Neighboring gene microRNA 3967 Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3-like Neighboring gene amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    carboxy-lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    glutamate binding ISO
    Inferred from Sequence Orthology
    more info
     
    glutamate decarboxylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    pyridoxal phosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    carboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    glutamate decarboxylation to succinate ISO
    Inferred from Sequence Orthology
    more info
     
    neurotransmitter biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    anchored component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    inhibitory synapse ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    glutamate decarboxylase 2
    Names
    65 kDa glutamic acid decarboxylase
    GAD-65
    glutamate decarboxylase 65 kDa isoform
    NP_032104.2
    XP_011237325.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008078.2NP_032104.2  glutamate decarboxylase 2

      See identical proteins and their annotated locations for NP_032104.2

      Status: VALIDATED

      Source sequence(s)
      AL928693, BC018380, BQ571205
      Consensus CDS
      CCDS15724.1
      UniProtKB/Swiss-Prot
      P48320
      UniProtKB/TrEMBL
      Q548L4
      Related
      ENSMUSP00000028123.3, OTTMUSP00000012268, ENSMUST00000028123.3, OTTMUST00000026891
      Conserved Domains (1) summary
      pfam00282
      Location:138509
      Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      22621422..22693877
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239023.2XP_011237325.1  glutamate decarboxylase 2 isoform X1

      Conserved Domains (1) summary
      cl18945
      Location:138307
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
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