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    InR Insulin-like receptor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42549, updated on 8-Oct-2017
    Official Symbol
    InRprovided by FlyBase
    Official Full Name
    Insulin-like receptorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0283499
    Locus tag
    Dmel_CG18402
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    18402; CG18402; DIHR; DILR; dinr; dInr; dInR; dINR; DInr; DInR; dInsR; dir; dIR; DIR; Dir-a; Dir-b; DIRbeta; dIRH; DIRH; Dmel\CG18402; er10; inr; inR; Inr; INR; Inr-alpha; Inr-beta; INS; InsR; insulin/insulin-like growth factor receptor; IR; l(3)05545; l(3)93Dj; l(3)er10; lnR; sprout
    Location:
    93E4-93E9
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.13 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21570248..21619321, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (17395970..17445043, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene slouch Neighboring gene CG15498 gene product from transcript CG15498-RA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene mir-998 stem loop Neighboring gene mir-11 stem loop Neighboring gene E2F transcription factor 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Autophagy - animal, organism-specific biosystem (from KEGG)
      Autophagy - animal, organism-specific biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Autophagy - animal, conserved biosystem (from KEGG)
      Autophagy - animal, conserved biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • FoxO signaling pathway, organism-specific biosystem (from KEGG)
      FoxO signaling pathway, organism-specific biosystemThe forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative str...
    • Longevity regulating pathway - multiple species, organism-specific biosystem (from KEGG)
      Longevity regulating pathway - multiple species, organism-specific biosystemAging is a complex process of accumulation of molecular, cellular, and organ damage, leading to loss of function and increased vulnerability to disease and death. Despite the complexity of aging, rec...
    • Longevity regulating pathway - multiple species, conserved biosystem (from KEGG)
      Longevity regulating pathway - multiple species, conserved biosystemAging is a complex process of accumulation of molecular, cellular, and organ damage, leading to loss of function and increased vulnerability to disease and death. Despite the complexity of aging, rec...
    • mTOR signaling pathway, organism-specific biosystem (from KEGG)
      mTOR signaling pathway, organism-specific biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
    • mTOR signaling pathway, conserved biosystem (from KEGG)
      mTOR signaling pathway, conserved biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    mobile_element

    • Loc: c21610044-21609899 mobile_element_type = transposon:NOF{}1401

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    ATP binding IC
    Inferred by Curator
    more info
    PubMed 
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    insulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    insulin receptor substrate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    insulin-activated receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    insulin-activated receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    phosphatidylinositol 3-kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein tyrosine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein tyrosine kinase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    aging IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axon guidance TAS
    Traceable Author Statement
    more info
    PubMed 
    carbohydrate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to DNA damage stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cholesterol homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    determination of adult lifespan TAS
    Traceable Author Statement
    more info
    PubMed 
    developmental growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dorsal closure TAS
    Traceable Author Statement
    more info
    PubMed 
    embryo development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    embryonic development via the syncytial blastoderm IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    embryonic development via the syncytial blastoderm TAS
    Traceable Author Statement
    more info
    PubMed 
    female germ-line stem cell asymmetric division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    female gonad development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    female mating behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    germ-band shortening IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    germ-band shortening TAS
    Traceable Author Statement
    more info
    PubMed 
    germ-line stem-cell niche homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    growth TAS
    Traceable Author Statement
    more info
    PubMed 
    imaginal disc growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    insulin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    insulin receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    insulin receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    intestinal stem cell homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    male germ-line stem cell asymmetric division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of circadian sleep/wake cycle, sleep IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of peptide hormone secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    open tracheal system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ovarian follicle cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell growth NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell size NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of cell size TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of multicellular organism growth TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of organ growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of organ growth NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of organ growth TAS
    Traceable Author Statement
    more info
    PubMed 
    primary spermatocyte growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein autophosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein heterotetramerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell size NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of glucose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of multicellular organism growth TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of organ growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of organ growth NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to anoxia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to cocaine IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to nutrient TAS
    Traceable Author Statement
    more info
    PubMed 
    response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    somatic muscle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vitellogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    insulin receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Preferred Names
    CG18402 gene product from transcript CG18402-RB
    Names
    CG18402-PA
    CG18402-PB
    CG18402-PC
    CG18402-PD
    InR-PA
    InR-PB
    InR-PC
    InR-PD
    Insulin-like receptor
    Insulin-receptor
    drosophila insulin receptor
    insulin
    insulin receptor
    insulin receptor homolog
    insulin receptor homologue
    insulin-like receptor
    lethal(3)93Dj
    sprout
    NP_001138093.1
    NP_001138094.1
    NP_001138095.1
    NP_524436.2

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      21570248..21619321 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144621.3NP_001138093.1  Insulin-like receptor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138093.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P09208
      Related
      FBpp0288669.1, FBtr0290230
      Conserved Domains (6) summary
      cd05032
      Location:13641652
      PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
      cd00063
      Location:12241302
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00064
      Location:545592
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam00757
      Location:512645
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:356465
      Recep_L_domain; Receptor L domain
      pfam07714
      Location:13711650
      Pkinase_Tyr; Protein tyrosine kinase
    2. NM_079712.6NP_524436.2  Insulin-like receptor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524436.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P09208
      Related
      FBpp0083519.1, FBtr0084121
      Conserved Domains (6) summary
      cd05032
      Location:13641652
      PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
      cd00063
      Location:12241302
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00064
      Location:545592
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam00757
      Location:512645
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:356465
      Recep_L_domain; Receptor L domain
      pfam07714
      Location:13711650
      Pkinase_Tyr; Protein tyrosine kinase
    3. NM_001144622.2NP_001138094.1  Insulin-like receptor, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138094.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P09208
      Related
      FBpp0288670.1, FBtr0290231
      Conserved Domains (6) summary
      cd05032
      Location:13641652
      PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
      cd00063
      Location:12241302
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00064
      Location:545592
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam00757
      Location:512645
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:356465
      Recep_L_domain; Receptor L domain
      pfam07714
      Location:13711650
      Pkinase_Tyr; Protein tyrosine kinase
    4. NM_001144623.2NP_001138095.1  Insulin-like receptor, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138095.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P09208
      Related
      FBpp0288671.1, FBtr0290232
      Conserved Domains (6) summary
      cd05032
      Location:13641652
      PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
      cd00063
      Location:12241302
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00064
      Location:545592
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam00757
      Location:512645
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:356465
      Recep_L_domain; Receptor L domain
      pfam07714
      Location:13711650
      Pkinase_Tyr; Protein tyrosine kinase
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