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    Xrcc5 X-ray repair complementing defective repair in Chinese hamster cells 5 [ Mus musculus (house mouse) ]

    Gene ID: 22596, updated on 25-May-2017
    Official Symbol
    Xrcc5provided by MGI
    Official Full Name
    X-ray repair complementing defective repair in Chinese hamster cells 5provided by MGI
    Primary source
    MGI:MGI:104517
    See related
    Ensembl:ENSMUSG00000026187
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ku80; Ku86; AI314015
    Orthologs
    Location:
    1 C3; 1 36.5 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (72307417..72394953)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (72353995..72441527)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D230017M19 gene Neighboring gene peroxisomal trans-2-enoyl-CoA reductase Neighboring gene transmembrane protein 169 Neighboring gene predicted gene, 39661 Neighboring gene membrane-associated ring finger (C3HC4) 4 Neighboring gene ribosomal protein L17 pseudogene

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to 5'-deoxyribose-5-phosphate lyase activity ISO
    Inferred from Sequence Orthology
    more info
     
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP-dependent DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to double-stranded telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity, acting on acid anhydrides IEA
    Inferred from Electronic Annotation
    more info
     
    macromolecular complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA recombination IEA
    Inferred from Electronic Annotation
    more info
     
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular hyperosmotic salinity response ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to X-ray ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to gamma radiation ISO
    Inferred from Sequence Orthology
    more info
     
    double-strand break repair IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
     
    double-strand break repair via nonhomologous end joining ISO
    Inferred from Sequence Orthology
    more info
     
    hematopoietic stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    leptotene IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of t-circle formation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    telomere maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Ku70:Ku80 complex ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nonhomologous end joining complex ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear chromosome, telomeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nuclear chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    protein-DNA complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    X-ray repair cross-complementing protein 5
    Names
    ATP-dependent DNA helicase 2 subunit 2
    ATP-dependent DNA helicase II 80 kDa subunit
    CTC box-binding factor 85 kDa subunit
    CTC85
    CTCBF
    DNA repair protein XRCC5
    Ku p80
    ku autoantigen protein p86 homolog
    nuclear factor IV
    NP_033559.2
    XP_006495955.1
    XP_006495956.1
    XP_017175361.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009533.2NP_033559.2  X-ray repair cross-complementing protein 5

      See identical proteins and their annotated locations for NP_033559.2

      Status: VALIDATED

      Source sequence(s)
      AK081633, AK165470, CJ220465
      Consensus CDS
      CCDS35608.1
      UniProtKB/Swiss-Prot
      P27641
      Related
      ENSMUSP00000027379.8, ENSMUST00000027379.8
      Conserved Domains (4) summary
      cd00873
      Location:244542
      KU80; Ku-core domain, Ku80 subfamily; Ku80 is a subunit of the Ku protein, which plays a key role in multiple nuclear processes such as DNA repair, chromosome maintenance, transcription regulation, and V(D)J recombination. The mechanism underlying the ...
      TIGR00578
      Location:9577
      ku70; ATP-dependent DNA helicase II, 70 kDa subunit (ku70)
      pfam03731
      Location:9244
      Ku_N; Ku70/Ku80 N-terminal alpha/beta domain
      pfam08785
      Location:594706
      Ku_PK_bind; Ku C terminal domain like

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      72307417..72394953
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006495892.2XP_006495955.1  X-ray repair cross-complementing protein 5 isoform X1

      Conserved Domains (4) summary
      cd00873
      Location:244542
      KU80; Ku-core domain, Ku80 subfamily; Ku80 is a subunit of the Ku protein, which plays a key role in multiple nuclear processes such as DNA repair, chromosome maintenance, transcription regulation, and V(D)J recombination. The mechanism underlying the ...
      TIGR00578
      Location:9577
      ku70; ATP-dependent DNA helicase II, 70 kDa subunit (ku70)
      pfam03731
      Location:9244
      Ku_N; Ku70/Ku80 N-terminal alpha/beta domain
      pfam08785
      Location:594722
      Ku_PK_bind; Ku C terminal domain like
    2. XM_017319872.1XP_017175361.1  X-ray repair cross-complementing protein 5 isoform X3

    3. XM_006495893.3XP_006495956.1  X-ray repair cross-complementing protein 5 isoform X2

      Conserved Domains (3) summary
      cd00873
      Location:225523
      KU80; Ku-core domain, Ku80 subfamily; Ku80 is a subunit of the Ku protein, which plays a key role in multiple nuclear processes such as DNA repair, chromosome maintenance, transcription regulation, and V(D)J recombination. The mechanism underlying the ...
      pfam03731
      Location:1225
      Ku_N; Ku70/Ku80 N-terminal alpha/beta domain
      pfam08785
      Location:575703
      Ku_PK_bind; Ku C terminal domain like
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