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    Rgs4 regulator of G-protein signaling 4 [ Mus musculus (house mouse) ]

    Gene ID: 19736, updated on 25-May-2017
    Official Symbol
    Rgs4provided by MGI
    Official Full Name
    regulator of G-protein signaling 4provided by MGI
    Primary source
    MGI:MGI:108409
    See related
    Ensembl:ENSMUSG00000038530 Vega:OTTMUSG00000020909
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ESTM48; ESTM50; AA004315; AA597169
    Orthologs
    Location:
    1 H2.3; 1 76.84 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (169741477..169747642, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (171671608..171677773, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 18900 Neighboring gene regulator of G-protein signaling 5 Neighboring gene predicted gene, 39698 Neighboring gene predicted gene, 39699

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
      Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
    • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
      Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    G-protein alpha-subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    GTPase activator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of G-protein coupled receptor protein signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    regulator of G-protein signaling 4

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009062.3NP_033088.2  regulator of G-protein signaling 4

      See identical proteins and their annotated locations for NP_033088.2

      Status: VALIDATED

      Source sequence(s)
      AK030536, BB459021, CD741379
      Consensus CDS
      CCDS15465.1
      UniProtKB/Swiss-Prot
      O08899
      UniProtKB/TrEMBL
      Q5D078
      Related
      ENSMUSP00000027991.5, OTTMUSP00000022896, ENSMUST00000027991.11, OTTMUST00000049422
      Conserved Domains (1) summary
      cd08714
      Location:63176
      RGS_RGS4; Regulator of G protein signaling (RGS) domain found in the RGS4 protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      169741477..169747642 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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