Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    HMGB1 high mobility group box 1 [ Homo sapiens (human) ]

    Gene ID: 3146, updated on 25-May-2017
    Official Symbol
    HMGB1provided by HGNC
    Official Full Name
    high mobility group box 1provided by HGNC
    Primary source
    HGNC:HGNC:4983
    See related
    Ensembl:ENSG00000189403 MIM:163905; Vega:OTTHUMG00000016670
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HMG1; HMG3; HMG-1; SBP-1
    Summary
    This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2015]
    Orthologs
    Location:
    13q12.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 13 NC_000013.11 (30457916..30617597, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (31032877..31191942, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984577 Neighboring gene ubiquitin conjugating enzyme E2 L5, pseudogene Neighboring gene RNA binding motif protein 22 pseudogene 2 Neighboring gene microfibril associated protein 1 pseudogene 1 Neighboring gene protein tyrosine phosphatase, non-receptor type 2 pseudogene 2 Neighboring gene ubiquitin specific peptidase like 1 Neighboring gene transfer RNA-Asn (GTT) 2-4 Neighboring gene arachidonate 5-lipoxygenase activating protein

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.
    NHGRI GWA Catalog

    Replication interactions

    Interaction Pubs
    Knockdown of high mobility group box 1 (HMGB1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    • Activated TLR4 signalling, organism-specific biosystem (from REACTOME)
      Activated TLR4 signalling, organism-specific biosystemTLR4 is unique among the TLR family in its ability to recruit four adapters to activate two distinct signaling pathways. One pathway is activated by the pair of the adapters Mal or TIRAP (Toll/inter...
    • Activation of DNA fragmentation factor, organism-specific biosystem (from REACTOME)
      Activation of DNA fragmentation factor, organism-specific biosystemDNA fragmentation in response to apoptotic signals is achieved, in part, through the activity of apoptotic nucleases, termed DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) (reviewed ...
    • Advanced glycosylation endproduct receptor signaling, organism-specific biosystem (from REACTOME)
      Advanced glycosylation endproduct receptor signaling, organism-specific biosystemAdvanced Glycosylation End- product-specific Receptor (AGER) also known as Receptor for Advanced Glycation End-products (RAGE) is a multi-ligand membrane receptor belonging to the immunoglobulin supe...
    • Apoptosis, organism-specific biosystem (from REACTOME)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Apoptosis induced DNA fragmentation, organism-specific biosystem (from REACTOME)
      Apoptosis induced DNA fragmentation, organism-specific biosystemDNA fragmentation in response to apoptotic signals is achieved through the activity of two apoptotic nucleases, termed DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) and endonuclease...
    • Apoptotic execution phase, organism-specific biosystem (from REACTOME)
      Apoptotic execution phase, organism-specific biosystemIn the execution phase of apoptosis, effector caspases cleave vital cellular proteins leading to the morphological changes that characterize apoptosis. These changes include destruction of the nucle...
    • Autophagy - animal, organism-specific biosystem (from KEGG)
      Autophagy - animal, organism-specific biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Autophagy - animal, conserved biosystem (from KEGG)
      Autophagy - animal, conserved biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Base excision repair, organism-specific biosystem (from KEGG)
      Base excision repair, organism-specific biosystemBase excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair ...
    • Base excision repair, conserved biosystem (from KEGG)
      Base excision repair, conserved biosystemBase excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair ...
    • Cytosolic sensors of pathogen-associated DNA, organism-specific biosystem (from REACTOME)
      Cytosolic sensors of pathogen-associated DNA, organism-specific biosystemPresence of pathogen-associated DNA in cytosol induces type I IFN production. Several intracellular receptors have been implicated to some degree. These include DNA-dependent activator of interferon ...
    • DEx/H-box helicases activate type I IFN and inflammatory cytokines production, organism-specific biosystem (from REACTOME)
      DEx/H-box helicases activate type I IFN and inflammatory cytokines production, organism-specific biosystemDHX36 and DHX9 are aspartate-glutamate-any amino acid aspartate/histidine (DExD/H) box helicase (DHX) proteins that localize in the cytosol. The DHX RNA helicases family includes a large number of pr...
    • DNA Damage Response (only ATM dependent), organism-specific biosystem (from WikiPathways)
      DNA Damage Response (only ATM dependent), organism-specific biosystemThis is the second pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and TP53) which are connected with the first DNA damage response pathway. In...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • MyD88 cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
      MyD88 cascade initiated on plasma membrane, organism-specific biosystemMammalian myeloid differentiation factor 88 (MyD88) is Toll/interleukin (IL)-1 (TIR)-domain containing adapter protein which plays crucial role in TLR signaling. All TLRs, with only one exception of...
    • MyD88 dependent cascade initiated on endosome, organism-specific biosystem (from REACTOME)
      MyD88 dependent cascade initiated on endosome, organism-specific biosystemUpon binding of their ligands, TLR7/8 and TLR9 recruit a cytoplasmic adaptor MyD88 and IRAKs, downstream of which the signaling pathways are divided to induce either inflammatory cytokines or type I ...
    • MyD88-independent TLR3/TLR4 cascade, organism-specific biosystem (from REACTOME)
      MyD88-independent TLR3/TLR4 cascade, organism-specific biosystemMyD88-independent signaling pathway is shared by TLR3 and TLR4 cascades. TIR-domain-containing adapter-inducing interferon-beta (TRIF or TICAM1) is a key adapter molecule in transducing signals from ...
    • MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
      MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystemThe first known downstream component of TLR4 and TLR2 signaling is the adaptor MyD88. Another adapter MyD88-adaptor-like (Mal; also known as TIR-domain-containing adaptor protein or TIRAP) has also b...
    • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
      Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
    • Programmed Cell Death, organism-specific biosystem (from REACTOME)
      Programmed Cell Death, organism-specific biosystemCell death is a fundamental cellular response that has a crucial role in shaping our bodies during development and in regulating tissue homeostasis by eliminating unwanted cells. There are a number o...
    • RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystem (from REACTOME)
      RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystemRIG-I-like helicases (RLHs) the retinoic acid inducible gene-I (RIG-I) and melanoma differentiation associated gene 5 (MDA5) are RNA helicases that recognize viral RNA present within the cytoplasm. F...
    • RIP-mediated NFkB activation via ZBP1, organism-specific biosystem (from REACTOME)
      RIP-mediated NFkB activation via ZBP1, organism-specific biosystemOverexpression of human or murine ZBP1 (DAI) in human embryonic kidney 293T cells (HEK293T) activated NF-kB-dependent promoter in a dose-dependent manner. Two RHIM-contaning kinases RIP1 and RIP3 are...
    • Regulation of TLR by endogenous ligand, organism-specific biosystem (from REACTOME)
      Regulation of TLR by endogenous ligand, organism-specific biosystemDiverse molecules of host-cell origin may serve as endogenous ligands of Toll-like receptors (TLRs) (Erridge C 2010; Piccinini AM & Midwood KS 2010). These molecules are known as damage-associated mo...
    • Retinoblastoma (RB) in Cancer, organism-specific biosystem (from WikiPathways)
      Retinoblastoma (RB) in Cancer, organism-specific biosystemDescribes the role of retinoblastoma (RB) gene in cancer.
    • TAK1 activates NFkB by phosphorylation and activation of IKKs complex, organism-specific biosystem (from REACTOME)
      TAK1 activates NFkB by phosphorylation and activation of IKKs complex, organism-specific biosystemNF-kappaB is sequestered in the cytoplasm in a complex with inhibitor of NF-kappaB (IkB). Almost all NF-kappaB activation pathways are mediated by IkB kinase (IKK), which phosphorylates IkB resulting...
    • TRAF6 mediated NF-kB activation, organism-specific biosystem (from REACTOME)
      TRAF6 mediated NF-kB activation, organism-specific biosystemThe TRAF6/TAK1 signal activates a canonical IKK complex, resulting in the activation of NF-kB as well as MAPK cascades leading to the activation of AP-1. Although TRAF6/TAK1 has been implicated in To...
    • TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystem (from REACTOME)
      TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystemTRAF6 mediates NFkB activation via canonical phosphorylation of IKK complex by TAK1. TRAF6 and TAK1 also regulate MAPK cascades leading to the activation of AP-1.
    • TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystem (from REACTOME)
      TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystemTRIF(TICAM1) was shown to induce IRF3/7 and NF-?B activation and apoptosis through distinct intracellular signaling pathways [Han KJ et al 2004; Kaiser WJ and Offermann MK et al 2005]. TRIF consists...
    • Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystemLittle is known about TLR10 ligands. It has been established that the receptor homodimerizes upon binding and signals in an MyD88-dependent manner (Hasan U et al 2005; Nyman T et al 2008). It may als...
    • Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystemTLR2 is involved in recognition of peptidoglycan from gram-positive bacteria, bacterial lipoproteins, mycoplasma lipoprotein and mycobacterial products. It is quite possible that recognition of at le...
    • Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystemToll-like receptor 3 (TLR3) as was shown for mammals is expressed on myeloid dendritic cells, respiratory epithelium, macrophages, and appears to play a central role in mediating the antiviral and in...
    • Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystemToll-like Receptor 4 is a Microbe Associated Molecular Pattern receptor well known for it's sensitivity to Bacterial Lipopolysaccharides (LPS). LPS is assembled within diverse Gram-negative bacteria,...
    • Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystemTLR5 is the receptor for flagellin, the protein that forms bacterial flagella. Unlike most other Pathogen-Associated Molecular Patterns (PAMPs), flagellin does not undergo any posttranslational modif...
    • Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystemRNA can serve as a danger signal, both in its double-stranded form (that is associated with viral infection), as well as single-stranded RNA (ssRNA). Specifically, guanosine (G)- and uridine (U)-rich...
    • Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystemCpG DNA is an unusual Pathogen-Associated Molecular Pattern (PAMP). Cytosine methylation exists in mammalian but not bacterial cells, and most (but not all) CpG in the mammalian genome is methylated....
    • Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystemTLR1 is expressed by monocytes. TLR1 and TLR2 cotranslationally form heterodimeric complexes on the cell surface and in the cytosol. The TLR2:TLR1 complex recognizes Neisserial PorB and Mycobacterial...
    • Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystemTLR2 and TLR4 recognize different bacterial cell wall components. While TLR4 is trained onto Gram-negative lipopolysaccharide components, TLR2 - in combination with TLR6 - plays a major role in recog...
    • Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
      Toll-Like Receptors Cascades, organism-specific biosystemIn human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) doma...
    • ZBP1(DAI) mediated induction of type I IFNs, organism-specific biosystem (from REACTOME)
      ZBP1(DAI) mediated induction of type I IFNs, organism-specific biosystemZ-DNA-binding protein-1 (ZBP1), also known as, DNA-dependent activator of IFN-regulatory factors (DAI) was reported to initiate innate immune responses in murine L929 cells upon stimulation by multip...
    • amb2 Integrin signaling, organism-specific biosystem (from Pathway Interaction Database)
      amb2 Integrin signaling, organism-specific biosystem
      amb2 Integrin signaling
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • DKFZp686A04236

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    C-X-C chemokine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA binding, bending IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA binding, bending ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    DNA polymerase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RAGE receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    bubble DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    calcium-dependent protein kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    chemoattractant activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytokine activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    damaged DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    damaged DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    double-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    double-stranded RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    four-way junction DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lipopolysaccharide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lyase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylserine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    repressing transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    single-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    single-stranded RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    supercoiled DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transcription factor activity, sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA geometric change ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    DNA ligation involved in DNA repair ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    DNA recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    DNA topological change ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    T-helper 1 cell activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    T-helper 1 cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    V(D)J recombination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    activation of innate immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    activation of protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic DNA fragmentation TAS
    Traceable Author Statement
    more info
     
    apoptotic cell clearance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    base-excision repair IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin assembly IEA
    Inferred from Electronic Annotation
    more info
     
    dendritic cell chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    endothelial cell chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    eye development IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    inflammatory response to antigenic stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    innate immune response TAS
    Traceable Author Statement
    more info
     
    lung development IEA
    Inferred from Electronic Annotation
    more info
     
    macrophage activation involved in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    myeloid dendritic cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of CD4-positive, alpha-beta T cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of RNA polymerase II transcriptional preinitiation complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of apoptotic cell clearance IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of blood vessel endothelial cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of interferon-gamma production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neutrophil clearance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neutrophil degranulation TAS
    Traceable Author Statement
    more info
     
    plasmacytoid dendritic cell activation IEA
    Inferred from Electronic Annotation
    more info
     
    positive chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of DNA ligation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of NIK/NF-kappaB signaling IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of activated T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of dendritic cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of glycogen catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interferon-alpha production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interferon-beta production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-1 beta secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-1 secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of interleukin-10 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of interleukin-12 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interleukin-6 secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of mismatch repair IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of monocyte chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of myeloid cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of sprouting angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of toll-like receptor 2 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of toll-like receptor 4 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of toll-like receptor 9 signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of tumor necrosis factor production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of wound healing IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of T cell mediated immune response to tumor cell ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of nucleotide-excision repair IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of restriction endodeoxyribonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of tolerance induction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to glucocorticoid IEA
    Inferred from Electronic Annotation
    more info
     
    toll-like receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    tumor necrosis factor secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    condensed chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    early endosome IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum-Golgi intermediate compartment IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ficolin-1-rich granule lumen TAS
    Traceable Author Statement
    more info
     
    neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    secretory granule lumen TAS
    Traceable Author Statement
    more info
     
    colocalizes_with transcriptional repressor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    high mobility group protein B1
    Names
    Amphoterin
    Sulfoglucuronyl carbohydrate binding protein
    high-mobility group (nonhistone chromosomal) protein 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313892.1NP_001300821.1  high mobility group protein B1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK122825, AL353648, AV763680, BC030981, CB051582
      Consensus CDS
      CCDS9335.1
      UniProtKB/Swiss-Prot
      P09429
      UniProtKB/TrEMBL
      A0A024RDR0
      Related
      ENSP00000343040.4, OTTHUMP00000018196, ENST00000339872.8, OTTHUMT00000044356
      Conserved Domains (2) summary
      pfam00505
      Location:95162
      HMG_box; HMG (high mobility group) box
      pfam09011
      Location:778
      HMG_box_2; HMG-box domain
    2. NM_001313893.1NP_001300822.1  high mobility group protein B1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK122825, AL353648
      Consensus CDS
      CCDS9335.1
      UniProtKB/Swiss-Prot
      P09429
      UniProtKB/TrEMBL
      A0A024RDR0
      Related
      ENSP00000384678.1, OTTHUMP00000200117, ENST00000405805.5, OTTHUMT00000303998
      Conserved Domains (2) summary
      pfam00505
      Location:95162
      HMG_box; HMG (high mobility group) box
      pfam09011
      Location:778
      HMG_box_2; HMG-box domain
    3. NM_002128.5NP_002119.1  high mobility group protein B1

      See identical proteins and their annotated locations for NP_002119.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AA430980, AK122825, AL353648, BC030981
      Consensus CDS
      CCDS9335.1
      UniProtKB/Swiss-Prot
      P09429
      UniProtKB/TrEMBL
      A0A024RDR0
      Related
      ENSP00000345347.5, OTTHUMP00000018199, ENST00000341423.9, OTTHUMT00000044359
      Conserved Domains (2) summary
      pfam00505
      Location:95162
      HMG_box; HMG (high mobility group) box
      pfam09011
      Location:778
      HMG_box_2; HMG-box domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p7 Primary Assembly

      Range
      30457916..30617597 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018924.2 Alternate CHM1_1.1

      Range
      30999610..31159427 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center