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    Bmp4 bone morphogenetic protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 12159, updated on 16-May-2017
    Official Symbol
    Bmp4provided by MGI
    Official Full Name
    bone morphogenetic protein 4provided by MGI
    Primary source
    MGI:MGI:88180
    See related
    Ensembl:ENSMUSG00000021835 Vega:OTTMUSG00000019526
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bmp-4; Bmp2b; Bmp2b1; Bmp2b-1
    Summary
    This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Homozygous knockout mice die in utero, while a conditional knockout mouse exhibits defects in heart development. Transgenic mice overexpressing this gene in a neuron-specific manner exhibit a phenotype resembling the rare hereditary connective tissue disease, fibrodysplasia ossificans progressiva. [provided by RefSeq, Jul 2016]
    Orthologs
    Location:
    14 C1; 14 23.95 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (46383525..46390669, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (47003195..47010274, complement)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene ubiquitin pseudogene Neighboring gene predicted gene, 34499 Neighboring gene uncharacterized LOC102638002 Neighboring gene predicted gene 15217 Neighboring gene predicted gene, 34756 Neighboring gene RIKEN cDNA E130120K24 gene

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Adipogenesis genes, organism-specific biosystem (from WikiPathways)
      Adipogenesis genes, organism-specific biosystemThe different classes of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compos...
    • BMP Signaling Pathway in Eyelid Development, organism-specific biosystem (from WikiPathways)
      BMP Signaling Pathway in Eyelid Development, organism-specific biosystemThe signaling pathways involved in eyelid development are displayed with interactions that are known (solid arrows) and proposed (dotted arrows). The four main pathways shown are activated by Fgf10 a...
    • BMP signaling, organism-specific biosystem (from KEGG)
      BMP signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
    • BMP signaling, conserved biosystem (from KEGG)
      BMP signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
    • Basal cell carcinoma, organism-specific biosystem (from KEGG)
      Basal cell carcinoma, organism-specific biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
    • Basal cell carcinoma, conserved biosystem (from KEGG)
      Basal cell carcinoma, conserved biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
    • ESC Pluripotency Pathways, organism-specific biosystem (from WikiPathways)
      ESC Pluripotency Pathways, organism-specific biosystemThe cytokine LIF and its downstream effector STAT3 are essential for maintenance of pluripotency in mouse ES cells. The requirement for the transcription factor Oct3/4 for ES cell pluripotency is als...
    • Elastic fibre formation, organism-specific biosystem (from REACTOME)
      Elastic fibre formation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
      Extracellular matrix organization, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Fluid shear stress and atherosclerosis, organism-specific biosystem (from KEGG)
      Fluid shear stress and atherosclerosis, organism-specific biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
    • Fluid shear stress and atherosclerosis, conserved biosystem (from KEGG)
      Fluid shear stress and atherosclerosis, conserved biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
    • Heart Development, organism-specific biosystem (from WikiPathways)
      Heart Development, organism-specific biosystemThis pathway has been largely adapted from an article by Deepak Srivastava, Cell. 2006 Sep 22;126(6):1037-48. In this pathway are known transcription factors, miRNAs and regulatory proteins that impa...
    • Hippo signaling pathway, organism-specific biosystem (from KEGG)
      Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
    • Hippo signaling pathway, conserved biosystem (from KEGG)
      Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
    • Molecules associated with elastic fibres, organism-specific biosystem (from REACTOME)
      Molecules associated with elastic fibres, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • PluriNetWork, organism-specific biosystem (from WikiPathways)
      PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...
    • PodNet: protein-protein interactions in the podocyte, organism-specific biosystem (from WikiPathways)
      PodNet: protein-protein interactions in the podocyte, organism-specific biosystemPodNet is a manually curated network of protein-protein interactions occurring in the podocyte.
    • Signaling pathways regulating pluripotency of stem cells, organism-specific biosystem (from KEGG)
      Signaling pathways regulating pluripotency of stem cells, organism-specific biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
    • Signaling pathways regulating pluripotency of stem cells, conserved biosystem (from KEGG)
      Signaling pathways regulating pluripotency of stem cells, conserved biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
    • TGF Beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF Beta Signaling Pathway, organism-specific biosystemThe Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiat...
    • TGF-beta signaling pathway, organism-specific biosystem (from KEGG)
      TGF-beta signaling pathway, organism-specific biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
    • TGF-beta signaling pathway, conserved biosystem (from KEGG)
      TGF-beta signaling pathway, conserved biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
    • Thyroid hormone signaling pathway, organism-specific biosystem (from KEGG)
      Thyroid hormone signaling pathway, organism-specific biosystemThe thyroid hormones (THs) are important regulators of growth, development and metabolism. The action of TH is mainly mediated by T3 (3,5,3'-triiodo-L-thyronine). Thyroid hormones, L-thyroxine (T4) a...
    • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
      XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    BMP receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    BMP receptor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    chemoattractant activity ISO
    Inferred from Sequence Orthology
    more info
     
    co-receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytokine activity ISO
    Inferred from Sequence Orthology
    more info
     
    growth factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    heparin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    transforming growth factor beta receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    BMP signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    BMP signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    BMP signaling pathway involved in heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    BMP signaling pathway involved in heart induction ISO
    Inferred from Sequence Orthology
    more info
     
    BMP signaling pathway involved in nephric duct formation ISO
    Inferred from Sequence Orthology
    more info
     
    BMP signaling pathway involved in renal system segmentation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    BMP signaling pathway involved in ureter morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    SMAD protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    SMAD protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    activation of MAPKK activity ISO
    Inferred from Sequence Orthology
    more info
     
    anatomical structure formation involved in morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    anterior/posterior axis specification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    aortic valve morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT apoptotic process involved in endocardial cushion morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    blood vessel development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    bone development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    branching involved in prostate gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    branching involved in ureteric bud morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    branching involved in ureteric bud morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    branching morphogenesis of an epithelial tube ISO
    Inferred from Sequence Orthology
    more info
     
    bronchus development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    bud dilation involved in lung branching ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    bud elongation involved in lung branching IDA
    Inferred from Direct Assay
    more info
    PubMed 
    camera-type eye development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    camera-type eye development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    camera-type eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT cardiac jelly development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac muscle cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cardiac muscle cell differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    NOT cardiac right ventricle morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cartilage development IEA
    Inferred from Electronic Annotation
    more info
     
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cell fate commitment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to BMP stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to dexamethasone stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    chondrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cloacal septation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    common-partner SMAD protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    coronary vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cranial suture morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    deltoid tuberosity development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dorsal/ventral neural tube patterning IDA
    Inferred from Direct Assay
    more info
    PubMed 
    embryonic cranial skeleton morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic digit morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    embryonic hindlimb morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    embryonic limb morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    embryonic limb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic skeletal joint morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    embryonic skeletal joint morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic skeletal system morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endocardial cushion development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endochondral ossification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endoderm development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    epithelial cell proliferation involved in lung morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    NOT epithelial to mesenchymal transition involved in endocardial cushion formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epithelial tube branching involved in lung morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    epithelial-mesenchymal cell signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    epithelium development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    erythrocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT eye development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    forebrain development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    forebrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    germ cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glomerular capillary formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glomerular visceral epithelial cell development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hematopoietic progenitor cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hematopoietic progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    inner ear receptor cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    intermediate mesodermal cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    kidney development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    kidney development ISO
    Inferred from Sequence Orthology
    more info
     
    lens induction in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lung alveolus development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lung morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    lymphoid progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    macrophage differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    mammary gland formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    membranous septum morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mesenchymal cell differentiation involved in kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mesenchymal cell differentiation involved in renal system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mesenchymal cell proliferation involved in ureter development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    mesenchymal cell proliferation involved in ureteric bud development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    mesenchymal to epithelial transition involved in metanephros morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    mesoderm formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mesodermal cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mesodermal cell fate determination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    metanephric collecting duct development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    metanephros development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metanephros development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    monocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    NOT muscular septum morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of T cell differentiation in thymus ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of branching involved in ureteric bud morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of branching involved in ureteric bud morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of cell proliferation involved in heart morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of chondrocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of glomerular mesangial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of glomerulus development ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of immature T cell proliferation in thymus ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of mesenchymal cell proliferation involved in ureter development ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of metanephric S-shaped body morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of metanephric comma-shaped body morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of mitotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of myoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of oligodendrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of prostatic bud formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of prostatic bud formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of striated muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of thymocyte apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    neural tube closure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron fate commitment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    odontogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    odontogenesis of dentin-containing tooth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    odontogenesis of dentin-containing tooth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    organ induction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ossification IEA
    Inferred from Electronic Annotation
    more info
     
    osteoblast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    outflow tract morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    outflow tract septum morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ovarian follicle development ISO
    Inferred from Sequence Orthology
    more info
     
    pharyngeal arch artery morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pituitary gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of BMP signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of DNA-dependent DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of SMAD protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of bone mineralization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of branching involved in lung morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of branching involved in ureteric bud morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of calcium ion transport into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cardiac muscle fiber development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cartilage development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation involved in outflow tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of collagen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of endothelial cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of endothelial cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of endothelial cell migration TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of endothelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of epidermal cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of hepatocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of kidney development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mesenchymal stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ossification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of ossification ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of pathway-restricted SMAD protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of pathway-restricted SMAD protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of pri-miRNA transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of production of miRNAs involved in gene silencing by miRNA ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of store-operated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of vascular endothelial growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    post-embryonic development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    prostate gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    pulmonary artery endothelial tube morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    pulmonary valve morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of branching involved in prostate gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cartilage development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell fate commitment ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of endothelial cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of morphogenesis of a branching structure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of odontogenesis of dentin-containing tooth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of pathway-restricted SMAD protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of smooth muscle cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of smooth muscle cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of smooth muscle cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    renal system development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    renal system process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    secondary heart field specification ISO
    Inferred from Sequence Orthology
    more info
     
    skeletal system development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    smooth muscle cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    smooth muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    specification of animal organ position IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    steroid hormone mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    telencephalon development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    telencephalon regionalization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    telencephalon regionalization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    tendon cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    tissue development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    trachea development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    trachea formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    type B pancreatic cell development ISO
    Inferred from Sequence Orthology
    more info
     
    ureter epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ureter smooth muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ureteric bud development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ureteric bud development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ureteric bud development ISO
    Inferred from Sequence Orthology
    more info
     
    vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    proteinaceous extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    bone morphogenetic protein 4
    Names
    bone morphogenetic protein 2B

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316360.1NP_001303289.1  bone morphogenetic protein 4 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK136527, AK145359, CT009556
      Consensus CDS
      CCDS36897.1
      UniProtKB/Swiss-Prot
      P21275
      UniProtKB/TrEMBL
      Q3ULR1
      Related
      ENSMUSP00000098242.2, OTTMUSP00000021066, ENSMUST00000100676.2, OTTMUST00000046637
      Conserved Domains (2) summary
      smart00204
      Location:308408
      TGFB; Transforming growth factor-beta (TGF-beta) family
      pfam00688
      Location:41276
      TGFb_propeptide; TGF-beta propeptide
    2. NM_007554.3NP_031580.2  bone morphogenetic protein 4 preproprotein

      See identical proteins and their annotated locations for NP_031580.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK136527, AK145359, CT009556
      Consensus CDS
      CCDS36897.1
      UniProtKB/Swiss-Prot
      P21275
      UniProtKB/TrEMBL
      Q3ULR1
      Related
      ENSMUSP00000073720.5, OTTMUSP00000021065, ENSMUST00000074077.11, OTTMUST00000046636
      Conserved Domains (2) summary
      smart00204
      Location:308408
      TGFB; Transforming growth factor-beta (TGF-beta) family
      pfam00688
      Location:41276
      TGFb_propeptide; TGF-beta propeptide

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      46383525..46390669 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244935.2XP_011243237.1  bone morphogenetic protein 4 isoform X1

      See identical proteins and their annotated locations for XP_011243237.1

      UniProtKB/Swiss-Prot
      P21275
      UniProtKB/TrEMBL
      Q3ULR1
      Conserved Domains (2) summary
      smart00204
      Location:308408
      TGFB; Transforming growth factor-beta (TGF-beta) family
      pfam00688
      Location:41276
      TGFb_propeptide; TGF-beta propeptide
    2. XM_006518467.3XP_006518530.1  bone morphogenetic protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006518530.1

      UniProtKB/Swiss-Prot
      P21275
      UniProtKB/TrEMBL
      Q3ULR1
      Conserved Domains (2) summary
      smart00204
      Location:308408
      TGFB; Transforming growth factor-beta (TGF-beta) family
      pfam00688
      Location:41276
      TGFb_propeptide; TGF-beta propeptide
    3. XM_006518468.3XP_006518531.1  bone morphogenetic protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006518531.1

      UniProtKB/Swiss-Prot
      P21275
      UniProtKB/TrEMBL
      Q3ULR1
      Conserved Domains (2) summary
      smart00204
      Location:308408
      TGFB; Transforming growth factor-beta (TGF-beta) family
      pfam00688
      Location:41276
      TGFb_propeptide; TGF-beta propeptide
    4. XM_011244934.2XP_011243236.1  bone morphogenetic protein 4 isoform X1

      See identical proteins and their annotated locations for XP_011243236.1

      UniProtKB/Swiss-Prot
      P21275
      UniProtKB/TrEMBL
      Q3ULR1
      Conserved Domains (2) summary
      smart00204
      Location:308408
      TGFB; Transforming growth factor-beta (TGF-beta) family
      pfam00688
      Location:41276
      TGFb_propeptide; TGF-beta propeptide
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