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    Egfr epidermal growth factor receptor [ Mus musculus (house mouse) ]

    Gene ID: 13649, updated on 8-Oct-2017
    Official Symbol
    Egfrprovided by MGI
    Official Full Name
    epidermal growth factor receptorprovided by MGI
    Primary source
    MGI:MGI:95294
    See related
    Ensembl:ENSMUSG00000020122 Vega:OTTMUSG00000005185
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Wa5; wa2; Erbb; Errp; wa-2; Errb1; AI552599; 9030024J15Rik
    Orthologs
    Location:
    11 A2; 11 9.41 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (16752203..16913907)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (16652206..16813910)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene predicted gene 12664 Neighboring gene predicted gene, 39583 Neighboring gene predicted gene, 39584 Neighboring gene Egfr long non-coding downstream RNA Neighboring gene F-box protein 48

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    cadherin binding ISO
    Inferred from Sequence Orthology
    more info
     
    calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    epidermal growth factor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    epidermal growth factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    epidermal growth factor-activated receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    epidermal growth factor-activated receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to nitric-oxide synthase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    signal transducer activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transducer, downstream of receptor, with protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    activation of MAPKK activity ISO
    Inferred from Sequence Orthology
    more info
     
    astrocyte activation ISO
    Inferred from Sequence Orthology
    more info
     
    cell morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to amino acid stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to cadmium ion ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to epidermal growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to estradiol stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to reactive oxygen species ISO
    Inferred from Sequence Orthology
    more info
     
    cerebral cortex cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    digestive tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic placenta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epidermal growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    epidermal growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    epidermal growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    epidermis development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    eyelid development in camera-type eye IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    hair follicle development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    hair follicle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    learning or memory ISO
    Inferred from Sequence Orthology
    more info
     
    magnesium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    morphogenesis of an epithelial fold IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cardiocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    ovulation cycle ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-tyrosine autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of NIK/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of blood vessel diameter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of bone resorption ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of catenin import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of production of miRNAs involved in gene silencing by miRNA ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of prolactin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein kinase C activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of superoxide anion generation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of synaptic transmission, glutamatergic ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
     
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of nitric-oxide synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of phosphatidylinositol 3-kinase signaling ISO
    Inferred from Sequence Orthology
    more info
     
    response to UV-A ISO
    Inferred from Sequence Orthology
    more info
     
    response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    salivary gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    translation ISO
    Inferred from Sequence Orthology
    more info
     
    transmembrane receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    endocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    endosome ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with endosome ISO
    Inferred from Sequence Orthology
    more info
     
    endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    multivesicular body, internal vesicle lumen ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    receptor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    synapse ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    epidermal growth factor receptor
    Names
    avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
    waved 2
    NP_031938.1
    NP_997538.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007912.4NP_031938.1  epidermal growth factor receptor isoform 2 precursor

      See identical proteins and their annotated locations for NP_031938.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several exons and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK004883, AK004944
      Consensus CDS
      CCDS24444.1
      UniProtKB/TrEMBL
      Q9WVF5
      Related
      ENSMUSP00000099948.3, OTTMUSP00000005386, ENSMUST00000102884.9, OTTMUST00000011586
      Conserved Domains (5) summary
      smart00261
      Location:552598
      FU; Furin-like repeats
      cd00064
      Location:231274
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam00757
      Location:184335
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:57168
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:505636
      GF_recep_IV; Growth factor receptor domain IV
    2. NM_207655.2NP_997538.1  epidermal growth factor receptor isoform 1 precursor

      See identical proteins and their annotated locations for NP_997538.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AF275367, AK004883, AK163338, BQ553815, BY725722
      Consensus CDS
      CCDS24443.1
      UniProtKB/Swiss-Prot
      Q01279
      UniProtKB/TrEMBL
      Q3TQS6, Q9EP98, Q9WVF5
      Related
      ENSMUSP00000020329.6, OTTMUSP00000005385, ENSMUST00000020329.12, OTTMUST00000011585
      Conserved Domains (8) summary
      smart00219
      Location:715970
      TyrKc; Tyrosine kinase, catalytic domain
      cd12093
      Location:634679
      TM_ErbB1; Transmembrane domain of Epidermal Growth Factor Receptor or ErbB1, a Protein Tyrosine Kinase
      smart00261
      Location:552598
      FU; Furin-like repeats
      cd00064
      Location:231274
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      cd05108
      Location:7061018
      PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
      pfam00757
      Location:184335
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:57168
      Recep_L_domain; Receptor L domain
      pfam14843
      Location:505636
      GF_recep_IV; Growth factor receptor domain IV

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      16752203..16913907
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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