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    DNAJB11 DnaJ heat shock protein family (Hsp40) member B11 [ Homo sapiens (human) ]

    Gene ID: 51726, updated on 22-Apr-2017
    Official Symbol
    DNAJB11provided by HGNC
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member B11provided by HGNC
    Primary source
    HGNC:HGNC:14889
    See related
    Ensembl:ENSG00000090520 MIM:611341; Vega:OTTHUMG00000156614
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DJ9; EDJ; Dj-9; ERj3; ABBP2; ERdj3; ERj3p; ABBP-2; UNQ537; PRO1080
    Summary
    This gene encodes a soluble glycoprotein of the endoplasmic reticulum (ER) lumen that functions as a co-chaperone of binding immunoglobulin protein, a 70 kilodalton heat shock protein chaperone required for the proper folding and assembly of proteins in the ER. The encoded protein contains a highly conserved J domain of about 70 amino acids with a characteristic His-Pro-Asp (HPD) motif and may regulate the activity of binding immunoglobulin protein by stimulating ATPase activity. [provided by RefSeq, Mar 2014]
    Orthologs
    Location:
    3q27.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 3 NC_000003.12 (186570676..186585800)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (186288467..186303589)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene crystallin gamma S Neighboring gene TBCC domain containing 1 Neighboring gene uncharacterized LOC100287402 Neighboring gene alpha 2-HS glycoprotein

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 is identified to have a physical interaction with DnaJ (Hsp40) homolog, subfamily B, member 11 (DNAJB11) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 is identified to have a physical interaction with DnaJ (Hsp40) homolog, subfamily B, member 11 (DNAJB11) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    • IRE1alpha activates chaperones, organism-specific biosystem (from REACTOME)
      IRE1alpha activates chaperones, organism-specific biosystemIRE1-alpha is a single-pass transmembrane protein that resides in the endoplasmic reticulum (ER) membrane. The C-terminus of IRE1-alpha is located in the cytosol; the N-terminus is located in the ER ...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Photodynamic therapy-induced unfolded protein response, organism-specific biosystem (from WikiPathways)
      Photodynamic therapy-induced unfolded protein response, organism-specific biosystemPhotodynamic therapy may induce a proteotoxic stress response mediated by transcription factors heat shock factor 1 (HSF1), X-box binding protein 1 (XBP1), activating transcription factor (ATF) 6, an...
    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Unfolded Protein Response (UPR), organism-specific biosystem (from REACTOME)
      Unfolded Protein Response (UPR), organism-specific biosystemThe Unfolded Protein Response (UPR) is a regulatory system that protects the Endoplasmic Reticulum (ER) from overload. The UPR is provoked by the accumulation of improperly folded protein in the ER d...
    • XBP1(S) activates chaperone genes, organism-specific biosystem (from REACTOME)
      XBP1(S) activates chaperone genes, organism-specific biosystemXbp-1 (S) binds the sequence CCACG in ER Stress Responsive Elements (ERSE, consensus sequence CCAAT (N)9 CCACG) located upstream from many genes. The ubiquitous transcription factor NF-Y, a heterotri...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    IRE1-mediated unfolded protein response TAS
    Traceable Author Statement
    more info
     
    positive regulation of ATPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein folding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum TAS
    Traceable Author Statement
    more info
    PubMed 
    endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    dnaJ homolog subfamily B member 11
    Names
    APOBEC1-binding protein 2
    DnaJ (Hsp40) homolog, subfamily B, member 11
    DnaJ protein 9
    ER-associated DNAJ protein 3
    ER-associated Hsp40 co-chaperone
    ER-resident protein ERdj3
    PWP1-interacting protein 4
    endoplasmic reticulum DNA J domain-containing protein 3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034024.1 RefSeqGene

      Range
      5001..20125
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_016306.5NP_057390.1  dnaJ homolog subfamily B member 11 precursor

      See identical proteins and their annotated locations for NP_057390.1

      Status: REVIEWED

      Source sequence(s)
      AI446699, AY359043, BM754506, DA058195
      Consensus CDS
      CCDS3277.1
      UniProtKB/Swiss-Prot
      Q9UBS4
      Related
      ENSP00000265028.3, ENST00000265028.7
      Conserved Domains (3) summary
      cd10747
      Location:132329
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      COG0484
      Location:22344
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:2587
      DnaJ; DnaJ domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p7 Primary Assembly

      Range
      186570676..186585800
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018914.2 Alternate CHM1_1.1

      Range
      186252403..186267524
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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