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    Klrk1 killer cell lectin-like receptor subfamily K, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 27007, updated on 12-Mar-2017
    Official Symbol
    Klrk1provided by MGI
    Official Full Name
    killer cell lectin-like receptor subfamily K, member 1provided by MGI
    Primary source
    MGI:MGI:1196250
    See related
    Ensembl:ENSMUSG00000030149 Vega:OTTMUSG00000032505
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nkg2d; NKG2-D; D6H12S2489E
    Orthologs
    Location:
    6 F3; 6 63.44 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (129610323..129623864, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (129560339..129573859, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene killer cell lectin-like receptor family E member 1 Neighboring gene killer cell lectin-like receptor, subfamily D, member 1 Neighboring gene killer cell lectin-like receptor subfamily C, member 3 Neighboring gene killer cell lectin-like receptor subfamily C, member 2

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    MHC class I protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    MHC class Ib receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    defense response to Gram-positive bacterium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    natural killer cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    natural killer cell activation IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interferon-gamma production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of myeloid dendritic cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of natural killer cell mediated cytotoxicity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of natural killer cell mediated cytotoxicity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of nitric oxide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    stimulatory C-type lectin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    NKG2-D type II integral membrane protein
    Names
    NK cell receptor D
    NKG2-D-activating NK receptor
    natural killer cell group 2D

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083322.2NP_001076791.1  NKG2-D type II integral membrane protein isoform b

      See identical proteins and their annotated locations for NP_001076791.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform b, which has a shorter and distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AC171002, AF030313, BY207066
      Consensus CDS
      CCDS39661.1
      UniProtKB/Swiss-Prot
      O54709
      Related
      ENSMUSP00000093061, OTTMUSP00000073439, ENSMUST00000095412, OTTMUST00000140016
      Conserved Domains (1) summary
      cd03593
      Location:102216
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    2. NM_001286018.1NP_001272947.1  NKG2-D type II integral membrane protein isoform c

      See identical proteins and their annotated locations for NP_001272947.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform c, which contains a distinct N-terminus and an additional internal in-frame segment, and is shorter, compared to isoform a.
      Source sequence(s)
      AC171002
      Consensus CDS
      CCDS71846.1
      UniProtKB/TrEMBL
      Q3TCW7
      Related
      ENSMUSP00000130398, OTTMUSP00000073438, ENSMUST00000168919, OTTMUST00000140014
      Conserved Domains (2) summary
      cd03593
      Location:108222
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
      PHA03097
      Location:70223
      PHA03097; C-type lectin-like protein; Provisional
    3. NM_033078.4NP_149069.1  NKG2-D type II integral membrane protein isoform a

      See identical proteins and their annotated locations for NP_149069.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AA174479, AC171002, AK040436
      Consensus CDS
      CCDS39660.1
      UniProtKB/Swiss-Prot
      O54709
      UniProtKB/TrEMBL
      Q4FJM0
      Related
      ENSMUSP00000032252, OTTMUSP00000043132, ENSMUST00000032252, OTTMUST00000080884
      Conserved Domains (1) summary
      cd03593
      Location:115229
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      129610323..129623864 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241369.2XP_011239671.1  NKG2-D type II integral membrane protein isoform X1

      Conserved Domains (1) summary
      cd03593
      Location:115193
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
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