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    IL1A interleukin 1 alpha [ Homo sapiens (human) ]

    Gene ID: 3552, updated on 6-Dec-2016
    Official Symbol
    IL1Aprovided by HGNC
    Official Full Name
    interleukin 1 alphaprovided by HGNC
    Primary source
    HGNC:HGNC:5991
    See related
    Ensembl:ENSG00000115008 MIM:147760; Vega:OTTHUMG00000131315
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IL1; IL-1A; IL1F1; IL1-ALPHA
    Summary
    The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    2q14.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 2 NC_000002.12 (112773915..112785398, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (113531492..113542971, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724955 Neighboring gene 5'-nucleotidase domain containing 4 Neighboring gene cytoskeleton associated protein 2 like Neighboring gene interleukin 1 beta Neighboring gene X-linked inhibitor of apoptosis pseudogene 3

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.
    NHGRI GWA Catalog
    Meta-analysis of genome-wide association scans for genetic susceptibility to endometriosis in Japanese population.
    NHGRI GWA Catalog

    Replication interactions

    Interaction Pubs
    Infectious wild type HIV-1 production is enhanced by 293T cells over-expressing IL1A PubMed
    Knockdown of interleukin 1, alpha (IL1A) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta PubMed
    env HIV-1 gp120 increases the levels of prostaglandin E2 (PGE2) and IL-1 in human cells PubMed
    env Addition of HIV-1 gp120 to IL-1 treated human granulocytes or monocytes results in a slower movement that is chemokinetic (loss of directionality or random) in nature PubMed
    Envelope surface glycoprotein gp160, precursor env IL-1 and TNF-alpha production are induced by the treatment of cells with HIV-1 gp160 PubMed
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 or gp120 synthetic peptides induce the production of interleukin (IL)-1 and tumor necrosis factor (TNF); in contrast, gp41 or gp120 synthetic peptides are able to depress the production of interferon (IFN)-alpha, IFN-gamma, and IL-2 PubMed
    Tat tat IL1A is upregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed
    tat IL-1 stimulated NO production and iNOS mRNA expression are down-regulated by pretreatment with HIV-1 Tat-SOD fusion proteins in cultured chondrocytes PubMed
    tat HIV-1 Tat upregulates IL-1beta expression in a variety of cell types, including primary blood mononuclear cells (PBMCs), Jurkat and microglia PubMed
    tat HIV-1 Tat downregulates IL-1alpha expression in Raji cells PubMed
    Vpr vpr HIV-1 Vpr upregulates the gene expression of IL1A in human monocyte-derived dendritic cells PubMed
    nucleocapsid gag IL1A is upregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed

    Go to the HIV-1, Human Interaction Database

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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    copper ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytokine activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    interleukin-1 receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular response to heat IDA
    Inferred from Direct Assay
    more info
    PubMed 
    connective tissue replacement involved in inflammatory response wound healing IEA
    Inferred from Electronic Annotation
    more info
     
    cytokine-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ectopic germ cell programmed cell death IEA
    Inferred from Electronic Annotation
    more info
     
    extrinsic apoptotic signaling pathway in absence of ligand IEA
    Inferred from Electronic Annotation
    more info
     
    fever generation IEA
    Inferred from Electronic Annotation
    more info
     
    immune response IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    interleukin-1-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of extrinsic apoptotic signaling pathway in absence of ligand TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cytokine secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of interleukin-2 biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interleukin-6 production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of mitotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of monocyte chemotactic protein-1 production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of neutrophil extravasation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of vascular endothelial growth factor production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to copper ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Preferred Names
    interleukin-1 alpha
    Names
    IL-1 alpha
    hematopoietin-1
    preinterleukin 1 alpha
    pro-interleukin-1-alpha

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008850.1 RefSeqGene

      Range
      4997..16480
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000575.4NP_000566.3  interleukin-1 alpha precursor

      See identical proteins and their annotated locations for NP_000566.3

      Status: REVIEWED

      Source sequence(s)
      AA856674, AC079753, AK314850, BC035169, CA307202
      Consensus CDS
      CCDS2101.1
      UniProtKB/Swiss-Prot
      P01583
      Related
      ENSP00000263339, OTTHUMP00000161990, ENST00000263339, OTTHUMT00000254084
      Conserved Domains (2) summary
      smart00125
      Location:129267
      IL1; Interleukin-1 homologues
      pfam02394
      Location:1107
      IL1_propep; Interleukin-1 propeptide

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p7 Primary Assembly

      Range
      112773915..112785398 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018913.2 Alternate CHM1_1.1

      Range
      113535646..113546810 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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