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    Dtnbp1 dystrobrevin binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 94245, updated on 9-Jul-2017
    Official Symbol
    Dtnbp1provided by MGI
    Official Full Name
    dystrobrevin binding protein 1provided by MGI
    Primary source
    MGI:MGI:2137586
    See related
    Ensembl:ENSMUSG00000057531
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    sdy; Bloc1s8; AW048963; dysbindin; 5430437B18Rik
    Orthologs
    Location:
    13 A5; 13 21.73 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (44922077..45002096, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (45017448..45097465, complement)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 40931 Neighboring gene jumonji, AT rich interactive domain 2 Neighboring gene heat shock protein 25, pseudogene 1 Neighboring gene predicted gene, 34409

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Spontaneous (1) 
    • Targeted (4)  1 citation
    • Chemically induced (ENU) (1) 
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    actin cytoskeleton reorganization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    anterograde axonal transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    anterograde synaptic vesicle transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    blood coagulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    muscle organ development TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of dendritic spine morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    neuron projection morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    organelle organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    platelet dense granule organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neurotransmitter secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of JUN kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of dopamine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of dopamine secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    BLOC-1 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    BLOC-1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    midbody ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density of dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic density of dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    sarcolemma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sarcoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synapse IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    dysbindin
    Names
    BLOC-1 subunit 8
    HPS7 protein homolog
    biogenesis of lysosome-related organelles complex 1 subunit 8
    dysbindin-1
    hermansky-Pudlak syndrome 7 protein homolog
    sandy

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025772.4NP_080048.2  dysbindin

      See identical proteins and their annotated locations for NP_080048.2

      Status: PROVISIONAL

      Source sequence(s)
      AC159210, AC166074
      Consensus CDS
      CCDS36647.1
      UniProtKB/Swiss-Prot
      Q91WZ8
      Related
      ENSMUSP00000072170.7, ENSMUST00000072329.14
      Conserved Domains (1) summary
      pfam04440
      Location:175316
      Dysbindin; Dysbindin (Dystrobrevin binding protein 1)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      44922077..45002096 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516984.3XP_006517047.1  dysbindin isoform X1

      Conserved Domains (1) summary
      pfam04440
      Location:19160
      Dysbindin; Dysbindin (Dystrobrevin binding protein 1)
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