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    Amot angiomotin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300289, updated on 22-Apr-2017
    Official Symbol
    Amotprovided by RGD
    Official Full Name
    angiomotinprovided by RGD
    Primary source
    RGD:1564027
    See related
    Ensembl:ENSRNOG00000007345
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564027
    Orthologs
    Location:
    Xq34
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (116751231..116810238, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) X NC_005120.3 (116890173..116949168, complement)

    Chromosome X - NC_005120.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein C19orf43 homolog Neighboring gene lipoma HMGIC fusion partner-like 1 Neighboring gene rCG23154-like Neighboring gene olfactory receptor pseudogene 1758

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016
    • Hippo signaling pathway, organism-specific biosystem (from KEGG)
      Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
    • Hippo signaling pathway, conserved biosystem (from KEGG)
      Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Signaling by Hippo, organism-specific biosystem (from REACTOME)
      Signaling by Hippo, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Tight junction, organism-specific biosystem (from KEGG)
      Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • Tight junction, conserved biosystem (from KEGG)
      Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    angiostatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    angiostatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    blood vessel endothelial cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    blood vessel endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    blood vessel morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    cell migration involved in gastrulation IEA
    Inferred from Electronic Annotation
    more info
     
    cell migration involved in gastrulation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular protein localization IEA
    Inferred from Electronic Annotation
    more info
     
    cellular protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of cell polarity involved in ameboidal cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    establishment of cell polarity involved in ameboidal cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    gastrulation with mouth forming second IEA
    Inferred from Electronic Annotation
    more info
     
    gastrulation with mouth forming second ISO
    Inferred from Sequence Orthology
    more info
     
    hippo signaling IEA
    Inferred from Electronic Annotation
    more info
     
    hippo signaling ISO
    Inferred from Sequence Orthology
    more info
     
    in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of vascular permeability ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of blood vessel endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of small GTPase mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    vasculogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    vasculogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    COP9 signalosome IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with COP9 signalosome ISO
    Inferred from Sequence Orthology
    more info
     
    actin filament IEA
    Inferred from Electronic Annotation
    more info
     
    actin filament ISO
    Inferred from Sequence Orthology
    more info
     
    bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
     
    bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    endocytic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    ruffle IEA
    Inferred from Electronic Annotation
    more info
     
    ruffle ISO
    Inferred from Sequence Orthology
    more info
     
    stress fiber ISO
    Inferred from Sequence Orthology
    more info
     

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005120.4 Reference Rnor_6.0 Primary Assembly

      Range
      116751231..116810238 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006257424.3XP_006257486.1  angiomotin isoform X2

      Conserved Domains (3) summary
      pfam12200
      Location:692725
      DUF3597; Domain of unknown function (DUF3597)
      pfam12240
      Location:189435
      Angiomotin_C; Angiomotin C terminal
      pfam16034
      Location:121233
      JAKMIP_CC3; JAKMIP CC3 domain
    2. XM_006257423.3XP_006257485.1  angiomotin isoform X1

      See identical proteins and their annotated locations for XP_006257485.1

      UniProtKB/TrEMBL
      A0A0G2JX94
      Related
      ENSRNOP00000070184.1, ENSRNOT00000090918.1
      Conserved Domains (4) summary
      pfam03153
      Location:160392
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam12200
      Location:10811114
      DUF3597; Domain of unknown function (DUF3597)
      pfam12240
      Location:578824
      Angiomotin_C; Angiomotin C terminal
      cl12013
      Location:436617
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    3. XM_006257420.3XP_006257482.1  angiomotin isoform X1

      See identical proteins and their annotated locations for XP_006257482.1

      UniProtKB/TrEMBL
      A0A0G2JX94
      Conserved Domains (4) summary
      pfam03153
      Location:160392
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam12200
      Location:10811114
      DUF3597; Domain of unknown function (DUF3597)
      pfam12240
      Location:578824
      Angiomotin_C; Angiomotin C terminal
      cl12013
      Location:436617
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    4. XM_006257422.1XP_006257484.1  angiomotin isoform X1

      See identical proteins and their annotated locations for XP_006257484.1

      UniProtKB/TrEMBL
      A0A0G2JX94
      Conserved Domains (4) summary
      pfam03153
      Location:160392
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam12200
      Location:10811114
      DUF3597; Domain of unknown function (DUF3597)
      pfam12240
      Location:578824
      Angiomotin_C; Angiomotin C terminal
      cl12013
      Location:436617
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    5. XM_006257421.1XP_006257483.1  angiomotin isoform X1

      See identical proteins and their annotated locations for XP_006257483.1

      UniProtKB/TrEMBL
      A0A0G2JX94
      Conserved Domains (4) summary
      pfam03153
      Location:160392
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam12200
      Location:10811114
      DUF3597; Domain of unknown function (DUF3597)
      pfam12240
      Location:578824
      Angiomotin_C; Angiomotin C terminal
      cl12013
      Location:436617
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    Alternate Rn_Celera

    Genomic

    1. AC_000089.1 Alternate Rn_Celera

      Range
      108364426..108423279 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006227508.3XP_006227570.1  angiomotin isoform X2

      Conserved Domains (3) summary
      pfam12200
      Location:643676
      DUF3597; Domain of unknown function (DUF3597)
      pfam12240
      Location:189386
      Angiomotin_C; Angiomotin C terminal
      pfam16034
      Location:121233
      JAKMIP_CC3; JAKMIP CC3 domain
    2. XM_006227507.3XP_006227569.1  angiomotin isoform X1

      See identical proteins and their annotated locations for XP_006227569.1

      Conserved Domains (5) summary
      pfam03153
      Location:160392
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam12200
      Location:10321065
      DUF3597; Domain of unknown function (DUF3597)
      pfam12240
      Location:578775
      Angiomotin_C; Angiomotin C terminal
      pfam15619
      Location:420589
      Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
      cl12013
      Location:436617
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    3. XM_006227504.3XP_006227566.1  angiomotin isoform X1

      See identical proteins and their annotated locations for XP_006227566.1

      Conserved Domains (5) summary
      pfam03153
      Location:160392
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam12200
      Location:10321065
      DUF3597; Domain of unknown function (DUF3597)
      pfam12240
      Location:578775
      Angiomotin_C; Angiomotin C terminal
      pfam15619
      Location:420589
      Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
      cl12013
      Location:436617
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    4. XM_006227506.1XP_006227568.1  angiomotin isoform X1

      See identical proteins and their annotated locations for XP_006227568.1

      Conserved Domains (5) summary
      pfam03153
      Location:160392
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam12200
      Location:10321065
      DUF3597; Domain of unknown function (DUF3597)
      pfam12240
      Location:578775
      Angiomotin_C; Angiomotin C terminal
      pfam15619
      Location:420589
      Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
      cl12013
      Location:436617
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    5. XM_006227505.1XP_006227567.1  angiomotin isoform X1

      See identical proteins and their annotated locations for XP_006227567.1

      Conserved Domains (5) summary
      pfam03153
      Location:160392
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam12200
      Location:10321065
      DUF3597; Domain of unknown function (DUF3597)
      pfam12240
      Location:578775
      Angiomotin_C; Angiomotin C terminal
      pfam15619
      Location:420589
      Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
      cl12013
      Location:436617
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
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