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    PPP1R12A protein phosphatase 1 regulatory subunit 12A [ Homo sapiens (human) ]

    Gene ID: 4659, updated on 6-May-2018
    Official Symbol
    PPP1R12Aprovided by HGNC
    Official Full Name
    protein phosphatase 1 regulatory subunit 12Aprovided by HGNC
    Primary source
    HGNC:HGNC:7618
    See related
    Ensembl:ENSG00000058272 MIM:602021; Vega:OTTHUMG00000170100
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MBS; M130; MYPT1
    Summary
    Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
    Expression
    Ubiquitous expression in endometrium (RPKM 18.7), esophagus (RPKM 16.4) and 24 other tissues See more
    Orthologs
    See PPP1R12A in Genome Data Viewer
    Location:
    12q21.2-q21.31
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (79773563..79935764, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (80167343..80329235, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene NOP56 ribonucleoprotein pseudogene 3 Neighboring gene pro-apoptotic WT1 regulator Neighboring gene uncharacterized LOC105369864 Neighboring gene RNA, 5S ribosomal pseudogene 363 Neighboring gene PPP1R12A antisense RNA 1 Neighboring gene small nuclear ribonucleoprotein polypeptide G pseudogene 20 Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 20

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Treatment of human brain endothelial cells with Tat markedly elevate GTP-RhoA levels and the potential downstream effectors, such as myosin phosphatase target subunit 1 and myosin light chain PubMed
    nucleocapsid gag HIV-1 NC is identified to have a physical interaction with protein phosphatase 1, regulatory subunit 12A (PPP1R12A; YMPT1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • G2/M Transition, organism-specific biosystem (from REACTOME)
      G2/M Transition, organism-specific biosystemCyclin A can also form complexes with Cdc2 (Cdk1). Together with three B-type cyclins, Cdc2 (Cdk1) regulates the transition from G2 into mitosis. These complexes are activated by dephosphorylation of...
    • Mitotic G2-G2/M phases, organism-specific biosystem (from REACTOME)
      Mitotic G2-G2/M phases, organism-specific biosystem
      Mitotic G2-G2/M phases
    • Oxytocin signaling pathway, organism-specific biosystem (from KEGG)
      Oxytocin signaling pathway, organism-specific biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
    • Oxytocin signaling pathway, conserved biosystem (from KEGG)
      Oxytocin signaling pathway, conserved biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
    • PLK1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      PLK1 signaling events, organism-specific biosystem
      PLK1 signaling events
    • Platelet activation, organism-specific biosystem (from KEGG)
      Platelet activation, organism-specific biosystemPlatelets play a key and beneficial role for primary hemostasis on the disruption of the integrity of vessel wall. Platelet adhesion and activation at sites of vascular wall injury is initiated by ad...
    • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
      Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • Proteoglycans in cancer, conserved biosystem (from KEGG)
      Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
      RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
    • RHO GTPases Activate ROCKs, organism-specific biosystem (from REACTOME)
      RHO GTPases Activate ROCKs, organism-specific biosystemRHO associated, coiled-coil containing protein kinases ROCK1 and ROCK2 consist of a serine/threonine kinase domain, a coiled-coil region, a RHO-binding domain and a plekstrin homology (PH) domain int...
    • RHO GTPases activate PAKs, organism-specific biosystem (from REACTOME)
      RHO GTPases activate PAKs, organism-specific biosystemThe PAKs (p21-activated kinases) are a family of serine/threonine kinases mainly implicated in cytoskeletal rearrangements. All PAKs share a conserved catalytic domain located at the carboxyl terminu...
    • RHO GTPases activate PKNs, organism-specific biosystem (from REACTOME)
      RHO GTPases activate PKNs, organism-specific biosystemProtein kinases N (PKN), also known as protein kinase C-related kinases (PKR) feature a C-terminal serine/threonine kinase domain and three RHO-binding motifs at the N-terminus. RHO GTPases RHOA, RHO...
    • Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
      Regulation of Actin Cytoskeleton, organism-specific biosystemhttp://www.genome.jp/kegg/pathway/hsa/hsa04810.html
    • Regulation of PLK1 Activity at G2/M Transition, organism-specific biosystem (from REACTOME)
      Regulation of PLK1 Activity at G2/M Transition, organism-specific biosystemThe kinase activity of PLK1 is required for cell cycle progression as PLK1 phosphorylates and regulates a number of cellular proteins during mitosis. Centrosomic AURKA (Aurora A kinase), catalyticall...
    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
      Regulation of actin cytoskeleton, organism-specific biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
      Regulation of actin cytoskeleton, conserved biosystem
      Regulation of actin cytoskeleton
    • RhoA signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      RhoA signaling pathway, organism-specific biosystem
      RhoA signaling pathway
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
      Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
    • Vascular smooth muscle contraction, organism-specific biosystem (from KEGG)
      Vascular smooth muscle contraction, organism-specific biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
    • Vascular smooth muscle contraction, conserved biosystem (from KEGG)
      Vascular smooth muscle contraction, conserved biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
    • cAMP signaling pathway, organism-specific biosystem (from KEGG)
      cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    • cAMP signaling pathway, conserved biosystem (from KEGG)
      cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    • cGMP-PKG signaling pathway, organism-specific biosystem (from KEGG)
      cGMP-PKG signaling pathway, organism-specific biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
    • cGMP-PKG signaling pathway, conserved biosystem (from KEGG)
      cGMP-PKG signaling pathway, conserved biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC133042

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    14-3-3 protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enzyme inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enzyme inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    phosphatase regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatase regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    G2/M transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
     
    cellular response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    centrosome cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of catalytic activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of myosin-light-chain-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of myosin-light-chain-phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT regulation of establishment of endothelial barrier IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of myosin-light-chain-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of nucleocytoplasmic transport IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    A band IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    A band ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    PTW/PP1 phosphatase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Z disc IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Z disc ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
     
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contractile fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    focal adhesion HDA PubMed 
    kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    protein phosphatase 1 regulatory subunit 12A
    Names
    myosin binding subunit
    myosin phosphatase, target subunit 1
    myosin phosphatase-targeting subunit 1
    protein phosphatase 1, regulatory (inhibitor) subunit 12A
    protein phosphatase myosin-binding subunit

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001143885.1NP_001137357.1  protein phosphatase 1 regulatory subunit 12A isoform a

      See identical proteins and their annotated locations for NP_001137357.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode isoform a.
      Source sequence(s)
      AC073569, AF458589, AK314193, BC111752
      Consensus CDS
      CCDS44947.1
      UniProtKB/Swiss-Prot
      O14974
      UniProtKB/TrEMBL
      B2RAH5
      Related
      ENSP00000261207.5, ENST00000261207.9
      Conserved Domains (5) summary
      cd00204
      Location:67252
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:47136
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:199252
      Ank_4; Ankyrin repeats (many copies)
      pfam15898
      Location:9311029
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:72103
      ANK; ANK repeat [structural motif]
    2. NM_001143886.1NP_001137358.1  protein phosphatase 1 regulatory subunit 12A isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AC073569, AK302692, BC111752
      Consensus CDS
      CCDS44948.1
      UniProtKB/Swiss-Prot
      O14974
      Related
      ENSP00000449514.1, OTTHUMP00000242814, ENST00000546369.5, OTTHUMT00000407256
      Conserved Domains (5) summary
      cd00204
      Location:13165
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam13637
      Location:112165
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:558
      Ank_5; Ankyrin repeats (many copies)
      pfam15898
      Location:844942
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:1849
      ANK; ANK repeat [structural motif]
    3. NM_001244990.1NP_001231919.1  protein phosphatase 1 regulatory subunit 12A isoform c

      See identical proteins and their annotated locations for NP_001231919.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an exon in the coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
      Source sequence(s)
      AC018476, AC073569, AC074270
      Consensus CDS
      CCDS58260.1
      UniProtKB/Swiss-Prot
      O14974
      Related
      ENSP00000416769.2, OTTHUMP00000242813, ENST00000437004.6, OTTHUMT00000407255
      Conserved Domains (5) summary
      cd00204
      Location:67252
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:47136
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:199252
      Ank_4; Ankyrin repeats (many copies)
      pfam15898
      Location:933994
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:72103
      ANK; ANK repeat [structural motif]
    4. NM_001244992.1NP_001231921.1  protein phosphatase 1 regulatory subunit 12A isoform d

      See identical proteins and their annotated locations for NP_001231921.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an exon in the coding region, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
      Source sequence(s)
      AC018476, AC073569, AC074270
      Consensus CDS
      CCDS58259.1
      UniProtKB/Swiss-Prot
      O14974
      Related
      ENSP00000446855.1, OTTHUMP00000242815, ENST00000550107.5, OTTHUMT00000407257
      Conserved Domains (5) summary
      cd00204
      Location:67252
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:47136
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:199252
      Ank_4; Ankyrin repeats (many copies)
      pfam15898
      Location:875973
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:72103
      ANK; ANK repeat [structural motif]
    5. NM_002480.2NP_002471.1  protein phosphatase 1 regulatory subunit 12A isoform a

      See identical proteins and their annotated locations for NP_002471.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode isoform a.
      Source sequence(s)
      AC073569, AK314193, BC111752, DC350703
      Consensus CDS
      CCDS44947.1
      UniProtKB/Swiss-Prot
      O14974
      UniProtKB/TrEMBL
      B2RAH5
      Related
      ENSP00000389168.2, OTTHUMP00000242812, ENST00000450142.6, OTTHUMT00000407254
      Conserved Domains (5) summary
      cd00204
      Location:67252
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:47136
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:199252
      Ank_4; Ankyrin repeats (many copies)
      pfam15898
      Location:9311029
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:72103
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

      Range
      79773563..79935764 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017019328.2XP_016874817.1  protein phosphatase 1 regulatory subunit 12A isoform X16

    2. XM_017019325.2XP_016874814.1  protein phosphatase 1 regulatory subunit 12A isoform X11

    3. XM_017019329.2XP_016874818.1  protein phosphatase 1 regulatory subunit 12A isoform X17

    4. XM_017019324.2XP_016874813.1  protein phosphatase 1 regulatory subunit 12A isoform X10

    5. XM_011538377.2XP_011536679.1  protein phosphatase 1 regulatory subunit 12A isoform X4

      Conserved Domains (5) summary
      cd00204
      Location:67252
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:47136
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:199252
      Ank_4; Ankyrin repeats (many copies)
      pfam15898
      Location:9451043
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:72103
      ANK; ANK repeat [structural motif]
    6. XM_011538385.2XP_011536687.1  protein phosphatase 1 regulatory subunit 12A isoform X19

      Conserved Domains (5) summary
      cd00204
      Location:67252
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:47136
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:199252
      Ank_4; Ankyrin repeats (many copies)
      pfam15898
      Location:816914
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:72103
      ANK; ANK repeat [structural motif]
    7. XM_017019326.2XP_016874815.1  protein phosphatase 1 regulatory subunit 12A isoform X13

    8. XM_017019323.2XP_016874812.1  protein phosphatase 1 regulatory subunit 12A isoform X6

    9. XM_011538383.3XP_011536685.1  protein phosphatase 1 regulatory subunit 12A isoform X12

      UniProtKB/Swiss-Prot
      O14974
      Conserved Domains (5) summary
      cd00204
      Location:67252
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:47136
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:199252
      Ank_4; Ankyrin repeats (many copies)
      pfam15898
      Location:872970
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:72103
      ANK; ANK repeat [structural motif]
    10. XM_011538384.2XP_011536686.1  protein phosphatase 1 regulatory subunit 12A isoform X14

      Conserved Domains (5) summary
      cd00204
      Location:67252
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:47136
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:199252
      Ank_4; Ankyrin repeats (many copies)
      pfam15898
      Location:855953
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:72103
      ANK; ANK repeat [structural motif]
    11. XM_011538379.2XP_011536681.1  protein phosphatase 1 regulatory subunit 12A isoform X7

      Conserved Domains (5) summary
      cd00204
      Location:67252
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:47136
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:199252
      Ank_4; Ankyrin repeats (many copies)
      pfam15898
      Location:9141012
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:72103
      ANK; ANK repeat [structural motif]
    12. XM_011538375.2XP_011536677.1  protein phosphatase 1 regulatory subunit 12A isoform X2

      Conserved Domains (5) summary
      cd00204
      Location:67252
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:47136
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:199252
      Ank_4; Ankyrin repeats (many copies)
      pfam15898
      Location:9581056
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:72103
      ANK; ANK repeat [structural motif]
    13. XM_011538380.2XP_011536682.1  protein phosphatase 1 regulatory subunit 12A isoform X8

      Conserved Domains (5) summary
      cd00204
      Location:67252
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:47136
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:199252
      Ank_4; Ankyrin repeats (many copies)
      pfam15898
      Location:9111009
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:72103
      ANK; ANK repeat [structural motif]
    14. XM_011538374.2XP_011536676.1  protein phosphatase 1 regulatory subunit 12A isoform X1

      Conserved Domains (5) summary
      cd00204
      Location:67252
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:47136
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:199252
      Ank_4; Ankyrin repeats (many copies)
      pfam15898
      Location:9701068
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:72103
      ANK; ANK repeat [structural motif]
    15. XM_005268887.4XP_005268944.1  protein phosphatase 1 regulatory subunit 12A isoform X9

      Conserved Domains (5) summary
      cd00204
      Location:67252
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:47136
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:199252
      Ank_4; Ankyrin repeats (many copies)
      pfam15898
      Location:931985
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:72103
      ANK; ANK repeat [structural motif]
    16. XM_011538378.3XP_011536680.1  protein phosphatase 1 regulatory subunit 12A isoform X5

      Conserved Domains (5) summary
      cd00204
      Location:67252
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:47136
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:199252
      Ank_4; Ankyrin repeats (many copies)
      pfam15898
      Location:9701024
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:72103
      ANK; ANK repeat [structural motif]
    17. XM_011538376.3XP_011536678.1  protein phosphatase 1 regulatory subunit 12A isoform X3

      Conserved Domains (5) summary
      cd00204
      Location:67252
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:47136
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:199252
      Ank_4; Ankyrin repeats (many copies)
      pfam15898
      Location:9701024
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:72103
      ANK; ANK repeat [structural motif]
    18. XM_017019327.2XP_016874816.1  protein phosphatase 1 regulatory subunit 12A isoform X15

    19. XM_017019330.2XP_016874819.1  protein phosphatase 1 regulatory subunit 12A isoform X18

    RNA

    1. XR_001748712.2 RNA Sequence

    2. XR_001748713.2 RNA Sequence

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