Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    Csf2 colony stimulating factor 2 (granulocyte-macrophage) [ Mus musculus (house mouse) ]

    Gene ID: 12981, updated on 13-Dec-2017
    Official Symbol
    Csf2provided by MGI
    Official Full Name
    colony stimulating factor 2 (granulocyte-macrophage)provided by MGI
    Primary source
    MGI:MGI:1339752
    See related
    Ensembl:ENSMUSG00000018916 Vega:OTTMUSG00000005663
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Csfgm; GMCSF; Gm-CSf; MGI-IGM
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    Location:
    11 B1.3; 11 32.13 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (54247270..54249899, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (54060772..54063401, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene predicted gene 12223 Neighboring gene Sdccag3 pseudogene Neighboring gene RIKEN cDNA 4933405E24 gene Neighboring gene acyl-CoA-binding protein ACBP pseudogene Neighboring gene interleukin 3 Neighboring gene acyl-CoA synthetase long-chain family member 6 Neighboring gene uncharacterized LOC108167900

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Clone Names

    • MGC151255, MGC151257

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cytokine activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytokine activity ISO
    Inferred from Sequence Orthology
    more info
     
    granulocyte macrophage colony-stimulating factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cellular response to granulocyte macrophage colony-stimulating factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    embryonic placenta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epithelial fluid transport ISO
    Inferred from Sequence Orthology
    more info
     
    histamine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    immune response IEA
    Inferred from Electronic Annotation
    more info
     
    macrophage activation ISO
    Inferred from Sequence Orthology
    more info
     
    monocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myeloid dendritic cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myeloid dendritic cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cytolysis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    neutrophil differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-23 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of macrophage derived foam cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of podosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of tyrosine phosphorylation of STAT protein ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of circadian sleep/wake cycle, sleep ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    granulocyte-macrophage colony-stimulating factor
    Names
    CSF
    colony-stimulating factor
    granulocyte-macrophage colony stimulating factor 2
    put. GM-CSF

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009969.4NP_034099.2  granulocyte-macrophage colony-stimulating factor precursor

      See identical proteins and their annotated locations for NP_034099.2

      Status: PROVISIONAL

      Source sequence(s)
      AL596103
      Consensus CDS
      CCDS24692.1
      UniProtKB/Swiss-Prot
      P01587
      UniProtKB/TrEMBL
      Q5SX78
      Related
      ENSMUSP00000019060.5, OTTMUSP00000005830, ENSMUST00000019060.5, OTTMUST00000012596
      Conserved Domains (1) summary
      smart00040
      Location:18135
      CSF2; Granulocyte-macrophage colony-simulating factor (GM-CSF)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      54247270..54249899 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532127.2XP_006532190.1  granulocyte-macrophage colony-stimulating factor isoform X1

      Conserved Domains (1) summary
      cl23816
      Location:1990
      CSF2; Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) is a member of the large family of polypeptide growth factors called cytokines. It stimulates a wide variety of hematopoietic and nonhematopoietic cell types via binding to members of the cytokine ...
    Support Center