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    CYLD CYLD lysine 63 deubiquitinase [ Homo sapiens (human) ]

    Gene ID: 1540, updated on 25-May-2017
    Official Symbol
    CYLDprovided by HGNC
    Official Full Name
    CYLD lysine 63 deubiquitinaseprovided by HGNC
    Primary source
    HGNC:HGNC:2584
    See related
    Ensembl:ENSG00000083799 MIM:605018; Vega:OTTHUMG00000173404
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EAC; MFT; SBS; TEM; BRSS; CDMT; MFT1; CYLD1; CYLDI; USPL2
    Summary
    This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    16q12.1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 16 NC_000016.10 (50742026..50801935)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (50775961..50835847)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927272 Neighboring gene sorting nexin 20 Neighboring gene nucleotide binding oligomerization domain containing 2 Neighboring gene uncharacterized LOC102724907 Neighboring gene microRNA 3181 Neighboring gene uncharacterized LOC105371251 Neighboring gene long intergenic non-protein coding RNA 2168 Neighboring gene RNA, 5S ribosomal pseudogene 426

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Cylindromatosis, familial
    MedGen: C1851526 OMIM: 132700 GeneReviews: Not available
    Compare labs
    Familial multiple trichoepitheliomata
    MedGen: C1275122 OMIM: 601606 GeneReviews: Not available
    Compare labs
    Spiegler-Brooke syndrome
    MedGen: C1857941 OMIM: 605041 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
    NHGRI GWA Catalog
    Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.
    NHGRI GWA Catalog
    Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
    NHGRI GWA Catalog
    Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy.
    NHGRI GWA Catalog

    Replication interactions

    Interaction Pubs
    Knockdown of CYLD by siRNA enhances HIV-1 infection in a single-cycle assay in HEK 293T cells, and the CYLD catalytic mutant C698A fails to reduce HIV-1 infection in 293T cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag HIV-1 transcription increases upon CYLD knockdown in CD4+ T lymphocytes, leading to upregulation of HIV-1 Gag/p24 levels in cells PubMed

    Go to the HIV-1, Human Interaction Database

    • Canonical NF-kappaB pathway, organism-specific biosystem (from Pathway Interaction Database)
      Canonical NF-kappaB pathway, organism-specific biosystem
      Canonical NF-kappaB pathway
    • Death Receptor Signalling, organism-specific biosystem (from REACTOME)
      Death Receptor Signalling, organism-specific biosystemThe death receptors, all cell-surface receptors, begin the process of caspase activation. The common feature of these type 1 transmembrane proteins is the "death-domain" a conserved cytoplasmic motif...
    • Deubiquitination, organism-specific biosystem (from REACTOME)
      Deubiquitination, organism-specific biosystemUbiquitination, the modification of proteins by the covalent attachment of ubiquitin (Ub), is a key regulatory mechanism for many many cellular processes, including protein degradation by the 26S pro...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • NOD1/2 Signaling Pathway, organism-specific biosystem (from REACTOME)
      NOD1/2 Signaling Pathway, organism-specific biosystemNOD1 is ubiquitously expressed, while NOD2 expression is restricted to monocytes, macrophages, dendritic cells, and intestinal Paneth cells (Inohara et al. 2005). NOD1 and NOD2 activation induces tra...
    • Negative regulators of RIG-I/MDA5 signaling, organism-specific biosystem (from REACTOME)
      Negative regulators of RIG-I/MDA5 signaling, organism-specific biosystemAs with other cytokine systems, production of type I IFN is a transient process, and can be hazardous to the host if unregulated, resulting in chronic cellular toxicity or inflammatory and autoimmune...
    • Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystem (from REACTOME)
      Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystemThe innate immune system is the first line of defense against invading microorganisms, a broad specificity response characterized by the recruitment and activation of phagocytes and the release of an...
    • Osteoclast differentiation, organism-specific biosystem (from KEGG)
      Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Osteoclast differentiation, conserved biosystem (from KEGG)
      Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • RIG-I-like Receptor Signaling, organism-specific biosystem (from WikiPathways)
      RIG-I-like Receptor Signaling, organism-specific biosystemViral pathogen RNA are recognized by host helicases called RIG-I-like receptors (RLRs) that include DDX58 (RIG-I), DHX58 (LGP2), IFIH1 (MDA5), SNW1, and DDX17. These RLR proteins then go on to initia...
    • RIG-I-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      RIG-I-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
    • RIG-I-like receptor signaling pathway, conserved biosystem (from KEGG)
      RIG-I-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
    • RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystem (from REACTOME)
      RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystemRIG-I-like helicases (RLHs) the retinoic acid inducible gene-I (RIG-I) and melanoma differentiation associated gene 5 (MDA5) are RNA helicases that recognize viral RNA present within the cytoplasm. F...
    • Regulation of TNFR1 signaling, organism-specific biosystem (from REACTOME)
      Regulation of TNFR1 signaling, organism-specific biosystemTumor necrosis factor-alpha (TNFalpha) is an inflammatory cytokine, that activates either cell survival (e.g.,inflammation, proliferation) or cell death upon association with TNF receptor 1 (TNFR1). ...
    • Regulation of toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
      Regulation of toll-like receptor signaling pathway, organism-specific biosystem
      Regulation of toll-like receptor signaling pathway
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • TNF receptor signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      TNF receptor signaling pathway, organism-specific biosystem
      TNF receptor signaling pathway
    • TNF signaling, organism-specific biosystem (from REACTOME)
      TNF signaling, organism-specific biosystemThe inflammatory cytokine tumor necrosis factor alpha (TNF-alpha) is expressed in immune and nonimmune cell types including macrophages, T cells, mast cells, granulocytes, natural killer (NK) cells, ...
    • TNFR1-induced NFkappaB signaling pathway, organism-specific biosystem (from REACTOME)
      TNFR1-induced NFkappaB signaling pathway, organism-specific biosystemActivation of tumor necrosis factor receptor 1 (TNFR1) can trigger multiple signal transduction pathways to induce inflammation, cell proliferation, survival or cell death (Ward C et al. 1999; Michea...
    • TNFR1-induced proapoptotic signaling, organism-specific biosystem (from REACTOME)
      TNFR1-induced proapoptotic signaling, organism-specific biosystemActivation of tumor necrosis factor receptor 1 (TNFR1) can trigger multiple signal transduction pathways to induce cell survival or cell death (Ward C et al. 1999; Micheau O and Tschopp J 2003; Wider...
    • Ub-specific processing proteases, organism-specific biosystem (from REACTOME)
      Ub-specific processing proteases, organism-specific biosystemUb-specific processing proteases (USPs) are the largest of the DUB families with more than 50 members in humans. The USP catalytic domain varies considerably in size and consists of six conserved mo...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • HSPC057, FLJ20180, FLJ31664, FLJ78684, KIAA0849

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    Lys48-specific deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Lys63-specific deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Lys63-specific deubiquitinase activity TAS
    Traceable Author Statement
    more info
     
    proline-rich region binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    thiol-dependent ubiquitin-specific protease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    thiol-dependent ubiquitinyl hydrolase activity TAS
    Traceable Author Statement
    more info
     
    zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    CD4-positive or CD8-positive, alpha-beta T cell lineage commitment IEA
    Inferred from Electronic Annotation
    more info
     
    Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    homeostasis of number of cells IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    necroptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of NF-kappaB import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of type I interferon production TAS
    Traceable Author Statement
    more info
     
    nucleotide-binding oligomerization domain containing signaling pathway TAS
    Traceable Author Statement
    more info
     
    positive regulation of T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of T cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cellular protein localization IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein K48-linked deubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    protein K63-linked deubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein deubiquitination TAS
    Traceable Author Statement
    more info
     
    protein linear deubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of B cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of tumor necrosis factor-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of tumor necrosis factor-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    ripoptosome assembly involved in necroptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ciliary basal body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ciliary tip ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    colocalizes_with cytoplasmic microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    extrinsic component of cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    ubiquitin carboxyl-terminal hydrolase CYLD
    Names
    cylindromatosis (turban tumor syndrome)
    deubiquitinating enzyme CYLD
    probable ubiquitin carboxyl-terminal hydrolase CYLD
    ubiquitin specific peptidase like 2
    ubiquitin thioesterase CYLD
    ubiquitin thiolesterase CYLD
    ubiquitin-specific-processing protease CYLD
    NP_001035814.1
    NP_001035877.1
    NP_056062.1
    XP_005255869.1
    XP_006721212.1
    XP_011521209.1
    XP_011521210.1
    XP_011521213.1
    XP_016878466.1
    XP_016878467.1
    XP_016878468.1
    XP_016878469.1
    XP_016878470.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012061.1 RefSeqGene

      Range
      5001..64886
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_491

    mRNA and Protein(s)

    1. NM_001042355.1NP_001035814.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 2

      See identical proteins and their annotated locations for NP_001035814.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks one exon in the 5' UTR and a second in-frame exon in the coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1. Variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AJ250014, AK056226, AL050166, BI458962, BX642061, DA157717, DA785459, DA940312
      Consensus CDS
      CCDS42164.1
      UniProtKB/Swiss-Prot
      Q9NQC7
      UniProtKB/TrEMBL
      A0A024R6T1
      Related
      ENSP00000457576.1, OTTHUMP00000250356, ENST00000569418.5, OTTHUMT00000422990
      Conserved Domains (3) summary
      smart01052
      Location:469537
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:590945
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:304468
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    2. NM_001042412.1NP_001035877.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 2

      See identical proteins and their annotated locations for NP_001035877.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an alternate 5' terminal exon, and lacks one exon in the 5' UTR and another in-frame exon in the coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1. Variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AB020656, AJ250014, AL050166, BC012342, DA157717, DA940312, DB119480
      Consensus CDS
      CCDS42164.1
      UniProtKB/Swiss-Prot
      Q9NQC7
      UniProtKB/TrEMBL
      A0A024R6T1
      Related
      ENSP00000381574.2, OTTHUMP00000250361, ENST00000398568.6, OTTHUMT00000422997
      Conserved Domains (3) summary
      smart01052
      Location:469537
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:590945
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:304468
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    3. NM_015247.2NP_056062.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform 1

      See identical proteins and their annotated locations for NP_056062.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AJ250014, AL050166, BX642061, DA157717, DA785459, DA940312
      Consensus CDS
      CCDS45482.1
      UniProtKB/Swiss-Prot
      Q9NQC7
      Related
      ENSP00000308928.9, OTTHUMP00000258945, ENST00000311559.13, OTTHUMT00000422992
      Conserved Domains (3) summary
      smart01052
      Location:472540
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:593948
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:307471
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p7 Primary Assembly

      Range
      50742026..50801935
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017022979.1XP_016878468.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

      UniProtKB/Swiss-Prot
      Q9NQC7
      UniProtKB/TrEMBL
      A0A024R6T1
      Related
      ENSP00000454515.1, OTTHUMP00000250357, ENST00000564326.5, OTTHUMT00000422993
      Conserved Domains (3) summary
      smart01052
      Location:469537
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:590945
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:304468
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    2. XM_017022981.1XP_016878470.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

      Conserved Domains (3) summary
      smart01052
      Location:459527
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:580935
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:304458
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    3. XM_005255812.2XP_005255869.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

      See identical proteins and their annotated locations for XP_005255869.1

      UniProtKB/Swiss-Prot
      Q9NQC7
      UniProtKB/TrEMBL
      A0A024R6T1
      Conserved Domains (3) summary
      smart01052
      Location:469537
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:590945
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:304468
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    4. XM_006721149.1XP_006721212.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

      See identical proteins and their annotated locations for XP_006721212.1

      UniProtKB/Swiss-Prot
      Q9NQC7
      UniProtKB/TrEMBL
      A0A024R6T1
      Conserved Domains (3) summary
      smart01052
      Location:469537
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:590945
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:304468
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    5. XM_011522908.1XP_011521210.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

      Conserved Domains (3) summary
      smart01052
      Location:459527
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:580935
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:304458
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    6. XM_011522911.2XP_011521213.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X3

      Conserved Domains (3) summary
      smart01052
      Location:469537
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cl02553
      Location:590619
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam16607
      Location:304468
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    7. XM_011522907.2XP_011521209.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

      See identical proteins and their annotated locations for XP_011521209.1

      UniProtKB/Swiss-Prot
      Q9NQC7
      UniProtKB/TrEMBL
      A0A024R6T1
      Conserved Domains (3) summary
      smart01052
      Location:469537
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:590945
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:304468
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    8. XM_017022977.1XP_016878466.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

      UniProtKB/Swiss-Prot
      Q9NQC7
      UniProtKB/TrEMBL
      A0A024R6T1
      Conserved Domains (3) summary
      smart01052
      Location:469537
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:590945
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:304468
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    9. XM_017022980.1XP_016878469.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

      UniProtKB/Swiss-Prot
      Q9NQC7
      UniProtKB/TrEMBL
      A0A024R6T1
      Conserved Domains (3) summary
      smart01052
      Location:469537
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:590945
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:304468
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured
    10. XM_017022978.1XP_016878467.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

      UniProtKB/Swiss-Prot
      Q9NQC7
      UniProtKB/TrEMBL
      A0A024R6T1
      Conserved Domains (3) summary
      smart01052
      Location:469537
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd02670
      Location:590945
      Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam16607
      Location:304468
      CYLD_phos_site; Phosphorylation region of CYLD, unstructured

    RNA

    1. XR_933218.1 RNA Sequence

    2. XR_001751849.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018927.2 Alternate CHM1_1.1

      Range
      52183487..52243322
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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