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    ARHGEF11 Rho guanine nucleotide exchange factor 11 [ Homo sapiens (human) ]

    Gene ID: 9826, updated on 22-Apr-2017
    Official Symbol
    ARHGEF11provided by HGNC
    Official Full Name
    Rho guanine nucleotide exchange factor 11provided by HGNC
    Primary source
    HGNC:HGNC:14580
    See related
    Ensembl:ENSG00000132694 MIM:605708; Vega:OTTHUMG00000041292
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GTRAP48; PDZ-RHOGEF
    Summary
    Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    1q23.1
    Exon count:
    47
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (156934840..157046903, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156904632..157015512, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene neurotrophic receptor tyrosine kinase 1 Neighboring gene insulin receptor related receptor Neighboring gene platelet endothelial aggregation receptor 1 Neighboring gene leucine rich repeat containing 71 Neighboring gene microRNA 765 Neighboring gene RNA, 7SL, cytoplasmic 612, pseudogene Neighboring gene uncharacterized LOC102724222 Neighboring gene homolog of C. elegans smu-1 pseudogene

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem (from REACTOME)
      Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystemp75NTR is a key regulator of neuronal apoptosis, both during development and after injury. Apoptosis is triggered by binding of either mature neurotrophin or proneurotrophin (proNGF, proBDNF). ProNG...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • G alpha (12/13) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (12/13) signalling events, organism-specific biosystemThe G12/13 family is probably the least well characterized subtype, partly because G12/13 coupling is difficult to determine when compared with the other subtypes which predominantly rely on assay te...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • NRAGE signals death through JNK, organism-specific biosystem (from REACTOME)
      NRAGE signals death through JNK, organism-specific biosystemOnce bound by either NGF or proNGF, p75NTR interacts with NRAGE, thus leading to phosphorylation and activation of JUN Kinase (JNK). JNK controls apoptosis in two ways: it induces transcription of pr...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Regulation of RhoA activity, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of RhoA activity, organism-specific biosystem
      Regulation of RhoA activity
    • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
      Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
    • Sema4D in semaphorin signaling, organism-specific biosystem (from REACTOME)
      Sema4D in semaphorin signaling, organism-specific biosystemSemaphorin 4D (Sema 4D/CD100) is an axon guidance molecule with two disulfide-linked 150-kDa subunits. SEMA4D is structurally defined by a conserved 500-amino acid extracellular domain with 16 cyste...
    • Sema4D induced cell migration and growth-cone collapse, organism-specific biosystem (from REACTOME)
      Sema4D induced cell migration and growth-cone collapse, organism-specific biosystemSema4D-mediated attraction of endothelial cells requires Rho, but not R-Ras, signaling. Sema4D-mediated plexinB1 activation activates Rho and its downstream effector ROCK. ROCK then phosphorylates ML...
    • Semaphorin interactions, organism-specific biosystem (from REACTOME)
      Semaphorin interactions, organism-specific biosystemSemaphorins are a large family of cell surface and secreted guidance molecules divided into eight classes on the basis of their structures. They all have an N-terminal conserved sema domain. Semaphor...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
      Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
    • Signaling events mediated by focal adhesion kinase, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by focal adhesion kinase, organism-specific biosystem
      Signaling events mediated by focal adhesion kinase
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
    • Vascular smooth muscle contraction, organism-specific biosystem (from KEGG)
      Vascular smooth muscle contraction, organism-specific biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
    • Vascular smooth muscle contraction, conserved biosystem (from KEGG)
      Vascular smooth muscle contraction, conserved biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
    • p75 NTR receptor-mediated signalling, organism-specific biosystem (from REACTOME)
      p75 NTR receptor-mediated signalling, organism-specific biosystemBesides signalling through the tyrosine kinase receptors TRK A, B, and C, the mature neurotrophins NGF, BDNF, and NT3/4 signal through their common receptor p75NTR. NGF binding to p75NTR activates a ...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • KIAA0380, DKFZp667F1223

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G-protein coupled receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    Rho guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    G-protein coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    Rho protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin cytoskeleton organization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cytokinesis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    establishment of cell polarity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    movement of cell or subcellular component NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of apoptotic process TAS
    Traceable Author Statement
    more info
     
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell growth NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
     
    striated muscle contraction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    intracellular IC
    Inferred by Curator
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    rho guanine nucleotide exchange factor 11
    Names
    Rho guanine exchange factor (GEF) 11
    Rho guanine nucleotide exchange factor (GEF) 11
    RhoA-specific guanine nucleotide exchange factor
    RhoGEF glutamate transport modulator
    glutamate transporter EAAT4-associated protein 48

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014784.3NP_055599.1  rho guanine nucleotide exchange factor 11 isoform 1

      See identical proteins and their annotated locations for NP_055599.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the predominant isoform (1).
      Source sequence(s)
      AB002378, AL157713, BC057394
      Consensus CDS
      CCDS1162.1
      UniProtKB/Swiss-Prot
      O15085
      Related
      ENSP00000354644.2, OTTHUMP00000038717, ENST00000361409.2, OTTHUMT00000098931
      Conserved Domains (6) summary
      cd08753
      Location:290434
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      COG0265
      Location:61139
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:46120
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:9391081
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:9991079
      PH; PH domain
      pfam00621
      Location:738922
      RhoGEF; RhoGEF domain
    2. NM_198236.2NP_937879.1  rho guanine nucleotide exchange factor 11 isoform 2

      See identical proteins and their annotated locations for NP_937879.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate in-frame exon, compared to variant 1. The resulting protein (isoform 2) is longer, compared to isoform 1.
      Source sequence(s)
      AL157713, BC057394
      Consensus CDS
      CCDS1163.1
      UniProtKB/Swiss-Prot
      O15085
      Related
      ENSP00000357177.3, OTTHUMP00000038716, ENST00000368194.7, OTTHUMT00000098930
      Conserved Domains (6) summary
      cd08753
      Location:330474
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      COG0265
      Location:61139
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:46120
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:9791121
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:10391119
      PH; PH domain
      pfam00621
      Location:778962
      RhoGEF; RhoGEF domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

      Range
      156934840..157046903 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006711663.3XP_006711726.1  rho guanine nucleotide exchange factor 11 isoform X8

      Conserved Domains (6) summary
      cd08753
      Location:326470
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      COG0265
      Location:57135
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:42116
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:9761118
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:10361116
      PH; PH domain
      pfam00621
      Location:775959
      RhoGEF; RhoGEF domain
    2. XM_017002923.1XP_016858412.1  rho guanine nucleotide exchange factor 11 isoform X13

    3. XM_017002921.1XP_016858410.1  rho guanine nucleotide exchange factor 11 isoform X9

    4. XM_005245629.4XP_005245686.1  rho guanine nucleotide exchange factor 11 isoform X7

      Conserved Domains (6) summary
      cd08753
      Location:330474
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      COG0265
      Location:61139
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:46120
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:9801122
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:10401120
      PH; PH domain
      pfam00621
      Location:779963
      RhoGEF; RhoGEF domain
    5. XM_017002920.1XP_016858409.1  rho guanine nucleotide exchange factor 11 isoform X5

    6. XM_017002924.1XP_016858413.1  rho guanine nucleotide exchange factor 11 isoform X14

    7. XM_011510185.2XP_011508487.1  rho guanine nucleotide exchange factor 11 isoform X3

      Conserved Domains (6) summary
      cd08753
      Location:341485
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      COG0265
      Location:72150
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:57131
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:9911133
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:10511131
      PH; PH domain
      pfam00621
      Location:790974
      RhoGEF; RhoGEF domain
    8. XM_017002922.1XP_016858411.1  rho guanine nucleotide exchange factor 11 isoform X12

    9. XM_006711665.3XP_006711728.1  rho guanine nucleotide exchange factor 11 isoform X11

      Conserved Domains (6) summary
      cd08753
      Location:306450
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      COG0265
      Location:77155
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:62136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:9551097
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:10151095
      PH; PH domain
      pfam00621
      Location:754938
      RhoGEF; RhoGEF domain
    10. XM_011510186.2XP_011508488.1  rho guanine nucleotide exchange factor 11 isoform X10

      Conserved Domains (6) summary
      cd08753
      Location:306450
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      COG0265
      Location:77155
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:62136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:9561098
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:10161096
      PH; PH domain
      pfam00621
      Location:755939
      RhoGEF; RhoGEF domain
    11. XM_006711662.2XP_006711725.1  rho guanine nucleotide exchange factor 11 isoform X6

      Conserved Domains (6) summary
      cd08753
      Location:346490
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      COG0265
      Location:77155
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:62136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:9851127
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:10451125
      PH; PH domain
      pfam00621
      Location:784968
      RhoGEF; RhoGEF domain
    12. XM_006711660.3XP_006711723.1  rho guanine nucleotide exchange factor 11 isoform X2

      Conserved Domains (6) summary
      cd08753
      Location:346490
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      COG0265
      Location:77155
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:62136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:9951137
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:10551135
      PH; PH domain
      pfam00621
      Location:794978
      RhoGEF; RhoGEF domain
    13. XM_006711661.2XP_006711724.1  rho guanine nucleotide exchange factor 11 isoform X4

      Conserved Domains (6) summary
      cd08753
      Location:346490
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      COG0265
      Location:77155
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:62136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:9861128
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:10461126
      PH; PH domain
      pfam00621
      Location:785969
      RhoGEF; RhoGEF domain
    14. XM_006711659.2XP_006711722.1  rho guanine nucleotide exchange factor 11 isoform X1

      Conserved Domains (6) summary
      cd08753
      Location:346490
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      COG0265
      Location:77155
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      cd00992
      Location:62136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13391
      Location:9961138
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:10561136
      PH; PH domain
      pfam00621
      Location:795979
      RhoGEF; RhoGEF domain
    15. XM_011510187.2XP_011508489.1  rho guanine nucleotide exchange factor 11 isoform X15

      Conserved Domains (5) summary
      cd08753
      Location:252396
      RGS_PDZRhoGEF; Regulator of G protein signaling (RGS) domain found in the PDZ-Rho guanine nucleotide exchange factor (RhoGEF) protein
      smart00228
      Location:242
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd13391
      Location:9021044
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:9621042
      PH; PH domain
      pfam00621
      Location:701885
      RhoGEF; RhoGEF domain
    16. XM_005245633.4XP_005245690.1  rho guanine nucleotide exchange factor 11 isoform X16

      Conserved Domains (4) summary
      cd13391
      Location:558700
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:618698
      PH; PH domain
      pfam00621
      Location:357541
      RhoGEF; RhoGEF domain
      cl02565
      Location:2105
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    17. XM_011510189.2XP_011508491.1  rho guanine nucleotide exchange factor 11 isoform X17

      Conserved Domains (3) summary
      cd13391
      Location:362504
      PH_PRG; PDZ Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00169
      Location:422502
      PH; PH domain
      pfam00621
      Location:161345
      RhoGEF; RhoGEF domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      158301064..158411558 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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