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    secM regulator of secA translation [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944831, updated on 19-Nov-2016
    Gene symbol
    secM
    Gene description
    regulator of secA translation
    Primary source
    EcoGene:EG11087
    Locus tag
    b0097
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0098; JW5007; srrA; yacA
    Summary
    Translation and secretion of SecM regulates downstream secA gene expression. [More information is available at EcoGene: EG11087]. SecM regulates production of co-translated SecA; reduced secretion of SecM acts as a "sensor" that stimulates translation of the SecA translocation factor via a translational pause at Pro166 that is caused by an arrest sequence that interacts with the ribosomal exit tunnel . [More information is available at EcoCyc: EG11087].
    Sequence:
    NC_000913.3 (107705..108217)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene GTP-binding tubulin-like cell division protein Neighboring gene UDP-3-O-acyl N-acetylglucosamine deacetylase Neighboring gene preprotein translocase subunit, ATPase Neighboring gene dGTP-preferring nucleoside triphosphate pyrophosphohydrolase

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Bacterial secretion system, organism-specific biosystem (from KEGG)
      Bacterial secretion system, organism-specific biosystemGram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other to...
    • Bacterial secretion system, conserved biosystem (from KEGG)
      Bacterial secretion system, conserved biosystemGram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other to...
    • Protein export, organism-specific biosystem (from KEGG)
      Protein export, organism-specific biosystemThe protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the ge...
    • Protein export, conserved biosystem (from KEGG)
      Protein export, conserved biosystemThe protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the ge...
    • Sec (secretion) system, organism-specific biosystem (from KEGG)
      Sec (secretion) system, organism-specific biosystemStructural complex; Environmental information processing; Bacterial secretion system
    • Sec (secretion) system, conserved biosystem (from KEGG)
      Sec (secretion) system, conserved biosystemStructural complex; Environmental information processing; Bacterial secretion system

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    translation regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    periplasmic space IDA
    Inferred from Direct Assay
    more info
    PubMed 

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      107705..108217
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414639.2 regulator of secA translation [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414639.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P62395
      Conserved Domains (1) summary
      PRK02943
      Location:2169
      PRK02943; SecA regulator SecM; Provisional
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