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    St14 suppression of tumorigenicity 14 (colon carcinoma) [ Mus musculus (house mouse) ]

    Gene ID: 19143, updated on 25-May-2017
    Official Symbol
    St14provided by MGI
    Official Full Name
    suppression of tumorigenicity 14 (colon carcinoma)provided by MGI
    Primary source
    MGI:MGI:1338881
    See related
    Ensembl:ENSMUSG00000031995 Vega:OTTMUSG00000029771
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mCAP3; MT-SP1; Prss14; Epithin; Tmprss14; matriptase
    Orthologs
    Location:
    9 A4; 9 16.61 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (31088590..31131882, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (30896175..30939384, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 29724 Neighboring gene zinc finger and BTB domain containing 44 Neighboring gene uncharacterized LOC105244993 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene amyloid beta (A4) precursor-like protein 2 Neighboring gene protein CEBPZOS pseudogene Neighboring gene predicted gene, 33535

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    serine-type endopeptidase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    serine-type peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    serine-type peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell migration TAS
    Traceable Author Statement
    more info
    PubMed 
    epithelial cell morphogenesis involved in placental branching IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    keratinocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    neural tube closure IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extrinsic component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    suppressor of tumorigenicity 14 protein homolog
    Names
    matriptase/MT-SP1
    protease, serine, 14 (epithin)
    serine protease 14
    NP_035306.2
    XP_006510161.1
    XP_006510162.1
    XP_017168702.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011176.4NP_035306.2  suppressor of tumorigenicity 14 protein homolog

      See identical proteins and their annotated locations for NP_035306.2

      Status: PROVISIONAL

      Source sequence(s)
      AC114542, CT025653
      Consensus CDS
      CCDS22948.1
      UniProtKB/Swiss-Prot
      P56677
      UniProtKB/TrEMBL
      Q543E3
      Related
      ENSMUSP00000034478.2, OTTMUSP00000038298, ENSMUST00000034478.2, OTTMUST00000073883
      Conserved Domains (5) summary
      smart00020
      Location:614849
      Tryp_SPc; Trypsin-like serine protease
      cd00041
      Location:340444
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00112
      Location:525559
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:615852
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam01390
      Location:88179
      SEA; SEA domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      31088590..31131882 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510098.3XP_006510161.1  suppressor of tumorigenicity 14 protein homolog isoform X2

      Conserved Domains (5) summary
      smart00020
      Location:592827
      Tryp_SPc; Trypsin-like serine protease
      cd00041
      Location:318422
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00112
      Location:503537
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:593830
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam01390
      Location:66157
      SEA; SEA domain
    2. XM_006510099.3XP_006510162.1  suppressor of tumorigenicity 14 protein homolog isoform X3

      Conserved Domains (4) summary
      smart00020
      Location:442677
      Tryp_SPc; Trypsin-like serine protease
      cd00041
      Location:168272
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00112
      Location:353387
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:443680
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    3. XM_017313213.1XP_017168702.1  suppressor of tumorigenicity 14 protein homolog isoform X1

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