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    Serpinf1 serpin family F member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287526, updated on 22-Apr-2017
    Official Symbol
    Serpinf1provided by RGD
    Official Full Name
    serpin family F member 1provided by RGD
    Primary source
    RGD:631369
    See related
    Ensembl:ENSRNOG00000003172
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pedf; Dmrs91
    Summary
    mouse homolog is a proteinase inhibitor involved in vascularization [RGD, Feb 2006]
    Orthologs
    Location:
    10q24
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (62241750..62254145, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (61954919..61969094, complement)

    Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene replication protein A1 Neighboring gene F-box only protein 5-like Neighboring gene SET and MYND domain containing 4 Neighboring gene similar to ribosomal protein L37 Neighboring gene serpin family F member 2 Neighboring gene WD repeat domain 81

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Wnt signaling pathway, organism-specific biosystem (from KEGG)
      Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt signaling pathway, conserved biosystem (from KEGG)
      Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    serine-type endopeptidase inhibitor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    aging IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to cobalt ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to dexamethasone stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to glucose stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to retinoic acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    kidney development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of angiogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of epithelial cell proliferation involved in prostate gland development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of epithelial cell proliferation involved in prostate gland development ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuron death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ovulation cycle IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    positive regulation of neurogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to acidic pH IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to arsenic-containing substance IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    retina development in camera-type eye IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    short-term memory IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon hillock IDA
    Inferred from Direct Assay
    more info
    PubMed 
    basement membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    pigment epithelium-derived factor
    Names
    alpha-2 antiplasmin
    serine (or cysteine) peptidase inhibitor, clade F, member 1
    serine (or cysteine) proteinase inhibitor, clade F), member 1
    serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
    sserpin family F member 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177927.2NP_808788.1  pigment epithelium-derived factor precursor

      See identical proteins and their annotated locations for NP_808788.1

      Status: PROVISIONAL

      Source sequence(s)
      AY216659
      UniProtKB/TrEMBL
      Q80ZA3
      Related
      ENSRNOP00000004313.4, ENSRNOT00000004313.5
      Conserved Domains (1) summary
      cd02052
      Location:40415
      PEDF; Pigment epithelium-derived factor (PEDF)_like. PEDF is non-inhibitory member of the Serpin superfamily. It exhibits neurotrophic, neuroprotective and antiangiogenic properties and is widely expressed in the developing and adult nervous systems. This ...

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

      Range
      62241750..62254145 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000078.1 Alternate Rn_Celera

      Range
      59279849..59291539 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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