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    PRLR prolactin receptor [ Homo sapiens (human) ]

    Gene ID: 5618, updated on 22-Apr-2017
    Official Symbol
    PRLRprovided by HGNC
    Official Full Name
    prolactin receptorprovided by HGNC
    Primary source
    HGNC:HGNC:9446
    See related
    Ensembl:ENSG00000113494 MIM:176761; Vega:OTTHUMG00000090789
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HPRL; MFAB; hPRLrI
    Summary
    This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011]
    Orthologs
    Location:
    5p13.2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 5 NC_000005.10 (35048295..35230589, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (35048861..35230823, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C21 Neighboring gene alanine--glyoxylate aminotransferase 2 Neighboring gene uncharacterized LOC105374724 Neighboring gene sperm flagellar 2 Neighboring gene interleukin 7 receptor

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Adipogenesis, organism-specific biosystem (from WikiPathways)
      Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • ErbB4 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      ErbB4 signaling events, organism-specific biosystem
      ErbB4 signaling events
    • Growth hormone receptor signaling, organism-specific biosystem (from REACTOME)
      Growth hormone receptor signaling, organism-specific biosystemGrowth hormone (Somatotropin or GH) is a key factor in determining lean body mass, stimulating the growth and metabolism of muscle, bone and cartilage cells, while reducing body fat. It has many othe...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
      Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
      Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, organism-specific biosystem
      Neuroactive ligand-receptor interaction
    • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, conserved biosystem
      Neuroactive ligand-receptor interaction
    • Ovarian Infertility Genes, organism-specific biosystem (from WikiPathways)
      Ovarian Infertility Genes, organism-specific biosystemOvarian bottleneck genes associated with infertility. A valuable approach to the study of infertility is the comparison of mutations of individual human and mouse genes associated with infertility ph...
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • Prolactin Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Prolactin Signaling Pathway, organism-specific biosystemProlactin (PRL), a pleiotropic polypeptide hormone, mostly secreted by the lactotrophic cells of anterior pituitary gland and to a lesser extent expressed in numerous extra pituitary tissues such as ...
    • Prolactin receptor signaling, organism-specific biosystem (from REACTOME)
      Prolactin receptor signaling, organism-specific biosystemProlactin (PRL) is a hormone secreted mainly by the anterior pituitary gland. It was originally identified by its ability to stimulate the development of the mammary gland and lactation, but is now k...
    • Prolactin signaling pathway, organism-specific biosystem (from KEGG)
      Prolactin signaling pathway, organism-specific biosystemProlactin (PRL) is a polypeptide hormone known to be involved in a wide range of biological functions including osmoregulation, lactation, reproduction, growth and development, endocrinology and meta...
    • Prolactin signaling pathway, conserved biosystem (from KEGG)
      Prolactin signaling pathway, conserved biosystemProlactin (PRL) is a polypeptide hormone known to be involved in a wide range of biological functions including osmoregulation, lactation, reproduction, growth and development, endocrinology and meta...
    • Signaling events mediated by PTP1B, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by PTP1B, organism-specific biosystem
      Signaling events mediated by PTP1B
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    ornithine decarboxylase activator activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    peptide hormone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    prolactin receptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    JAK-STAT cascade involved in growth hormone signaling pathway TAS
    Traceable Author Statement
    more info
     
    T cell activation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    activation of transmembrane receptor protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    embryo implantation TAS
    Traceable Author Statement
    more info
    PubMed 
    lactation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    negative regulation of apoptotic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    prolactin signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    steroid biosynthetic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endosome lumen TAS
    Traceable Author Statement
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    prolactin receptor
    Names
    hPRL receptor
    secreted prolactin binding protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029042.2 RefSeqGene

      Range
      5133..180025
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000949.6NP_000940.1  prolactin receptor isoform 1 precursor

      See identical proteins and their annotated locations for NP_000940.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript, and encodes the longest isoform (1, also known as long form).
      Source sequence(s)
      AC010368, AI079645, AK313270, BP357907, KF573643
      Consensus CDS
      CCDS3909.1
      UniProtKB/Swiss-Prot
      P16471
      Related
      ENSP00000482954.1, OTTHUMP00000275876, ENST00000618457.4, OTTHUMT00000207575
      Conserved Domains (3) summary
      cd00063
      Location:127225
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam12772
      Location:286362
      GHBP; Growth hormone receptor binding
      cl21522
      Location:24120
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    2. NM_001204314.2NP_001191243.1  prolactin receptor isoform 6 precursor

      See identical proteins and their annotated locations for NP_001191243.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks two in-frame coding exons compared to variant 1. This results in a shorter isoform (6, also known as deltaS1) missing an internal protein segment coding for the S1 motif, compared to isoform 1. This isoform has been shown to be expressed at the protein level on the cell surface, and is functional (PMID:12351696).
      Source sequence(s)
      AC010368, AF349939, AI079645, DA640476, KF573643
      Consensus CDS
      CCDS56358.1
      UniProtKB/Swiss-Prot
      P16471
      Related
      ENSP00000482689.1, ENST00000620785.4
      Conserved Domains (2) summary
      cd00063
      Location:26124
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam12772
      Location:185261
      GHBP; Growth hormone receptor binding
    3. NM_001204315.1NP_001191244.1  prolactin receptor isoform 2 precursor

      See identical proteins and their annotated locations for NP_001191244.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is alternatively spliced at the 3' end compared to variant 1. This results in a frame-shift and a shorter isoform (2, also known as intermediate form) with a distinct C-terminus compared to isoform 1. This isoform is functional, but has different tissue specific expression and signaling pattern from isoform 1 (PMID:10585417).
      Source sequence(s)
      AF166329, M31661
      Consensus CDS
      CCDS56362.1
      UniProtKB/Swiss-Prot
      P16471
      Related
      ENSP00000484768.1, ENST00000619676.4
      Conserved Domains (2) summary
      cd00063
      Location:127225
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:24120
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    4. NM_001204316.1NP_001191245.1  prolactin receptor isoform 3 precursor

      See identical proteins and their annotated locations for NP_001191245.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate 3' terminal exon compared to variant 1. This results in a frame-shift and a shorter isoform (3, also known as SF1a for short form 1a) with a distinct C-terminus compared to isoform 1. This isoform is functional with a dominant-negative effect on the function of isoform 1 (PMID:12580759).
      Source sequence(s)
      AF416619, M31661
      Consensus CDS
      CCDS56361.1
      UniProtKB/Swiss-Prot
      P16471
      Related
      ENSP00000441813.2, ENST00000542609.5
      Conserved Domains (2) summary
      cd00063
      Location:127225
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:24120
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    5. NM_001204317.1NP_001191246.1  prolactin receptor isoform 4 precursor

      See identical proteins and their annotated locations for NP_001191246.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) is missing an exon at the 3' end, and contains an alternate 3' terminal exon compared to variant 1. This results in a frame-shift and a shorter isoform (4, also known as SF1b for short form 1b) with a distinct C-terminus compared to isoform 1. This isoform is functional with a strong dominant-negative effect on the function of isoform 1 (PMID:12580759).
      Source sequence(s)
      AF416618, M31661
      Consensus CDS
      CCDS56360.1
      UniProtKB/Swiss-Prot
      P16471
      Related
      ENSP00000425300.2, ENST00000509140.5
      Conserved Domains (2) summary
      cd00063
      Location:127225
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:24120
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    6. NM_001204318.1NP_001191247.1  prolactin receptor isoform 5 precursor

      See identical proteins and their annotated locations for NP_001191247.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) is missing 3 consecutive exons, and contains an alternate 3' terminal exon compared to variant 1. This results in a frame-shift and a shorter isoform (5, also known as delta 7/11) with a distinct C-terminus compared to isoform 1. This isoform, lacking a transmembrane domain, but containing a complete extracellular binding domain, was shown to be a secreted, prolactin-binding protein (PMID:12580759).
      Source sequence(s)
      AF416619, M31661
      Consensus CDS
      CCDS56359.1
      UniProtKB/Swiss-Prot
      P16471
      Related
      ENSP00000422935.2, ENST00000514088.5
      Conserved Domains (2) summary
      cd00063
      Location:127225
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:24120
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RNA

    1. NR_037910.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks two non-consecutive exons, and contains an alternate 3' terminal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF416619, AF493069, M31661
      Related
      ENST00000618625.4, OTTHUMT00000366862

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p7 Primary Assembly

      Range
      35048295..35230589 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017009646.1XP_016865135.1  prolactin receptor isoform X3

      UniProtKB/Swiss-Prot
      P16471
      Conserved Domains (2) summary
      cd00063
      Location:127225
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:24120
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    2. XM_017009645.1XP_016865134.1  prolactin receptor isoform X2

    3. XM_006714484.2XP_006714547.1  prolactin receptor isoform X1

      See identical proteins and their annotated locations for XP_006714547.1

      UniProtKB/Swiss-Prot
      P16471
      Conserved Domains (3) summary
      cd00063
      Location:127225
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam12772
      Location:286362
      GHBP; Growth hormone receptor binding
      cl21522
      Location:24120
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    4. XM_011514068.2XP_011512370.1  prolactin receptor isoform X1

      See identical proteins and their annotated locations for XP_011512370.1

      UniProtKB/Swiss-Prot
      P16471
      Conserved Domains (3) summary
      cd00063
      Location:127225
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam12772
      Location:286362
      GHBP; Growth hormone receptor binding
      cl21522
      Location:24120
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    5. XM_011514069.2XP_011512371.1  prolactin receptor isoform X1

      See identical proteins and their annotated locations for XP_011512371.1

      UniProtKB/Swiss-Prot
      P16471
      Conserved Domains (3) summary
      cd00063
      Location:127225
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam12772
      Location:286362
      GHBP; Growth hormone receptor binding
      cl21522
      Location:24120
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    Alternate CHM1_1.1

    Genomic

    1. NC_018916.2 Alternate CHM1_1.1

      Range
      35051181..35232962 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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