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    TRPV4 transient receptor potential cation channel subfamily V member 4 [ Homo sapiens (human) ]

    Gene ID: 59341, updated on 5-Nov-2017
    Official Symbol
    TRPV4provided by HGNC
    Official Full Name
    transient receptor potential cation channel subfamily V member 4provided by HGNC
    Primary source
    HGNC:HGNC:18083
    See related
    Ensembl:ENSG00000111199 MIM:605427; Vega:OTTHUMG00000169277
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SMAL; VRL2; BCYM3; CMT2C; SPSMA; TRP12; VROAC; HMSN2C; OTRPC4; SSQTL1
    Summary
    This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
    Orthologs
    Location:
    12q24.11
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 12 NC_000012.12 (109783087..109833407, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (110220892..110271212, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SK small nuclear pseudogene 250 Neighboring gene family with sequence similarity 222 member A Neighboring gene FAM222A antisense RNA 1 Neighboring gene uncharacterized LOC105369975 Neighboring gene microRNA 4497 Neighboring gene glycolipid transfer protein Neighboring gene RNA, 7SL, cytoplasmic 441, pseudogene

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Avascular necrosis of femoral head, primary, 2
    MedGen: CN240839 OMIM: 617383 GeneReviews: Not available
    Compare labs
    Brachyrachia (short spine dysplasia)
    MedGen: C0432227 OMIM: 113500 GeneReviews: TRPV4-Associated Disorders
    Compare labs
    Charcot-Marie-Tooth disease type 2C Compare labs
    Digital arthropathy-brachydactyly, familial
    MedGen: C1847406 OMIM: 606835 GeneReviews: Not available
    Compare labs
    Distal spinal muscular atrophy, congenital nonprogressive
    MedGen: C1838492 OMIM: 600175 GeneReviews: TRPV4-Associated Disorders
    Compare labs
    Metatrophic dysplasia
    MedGen: C0265281 OMIM: 156530 GeneReviews: TRPV4-Associated Disorders
    Compare labs
    Parastremmatic dwarfism
    MedGen: C1868616 OMIM: 168400 GeneReviews: TRPV4-Associated Disorders
    Compare labs
    Scapuloperoneal spinal muscular atrophy
    MedGen: C0751335 OMIM: 181405 GeneReviews: TRPV4-Associated Disorders
    Compare labs
    Sodium serum level quantitative trait locus 1
    MedGen: C3150755 OMIM: 613508 GeneReviews: Not available
    Compare labs
    Spondyloepiphyseal dysplasia Maroteaux type
    MedGen: C3159322 OMIM: 184095 GeneReviews: TRPV4-Associated Disorders
    Compare labs
    Spondylometaphyseal dysplasia, Kozlowski type
    MedGen: C0265280 OMIM: 184252 GeneReviews: TRPV4-Associated Disorders
    Compare labs
    • Fluid shear stress and atherosclerosis, organism-specific biosystem (from KEGG)
      Fluid shear stress and atherosclerosis, organism-specific biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
    • Fluid shear stress and atherosclerosis, conserved biosystem (from KEGG)
      Fluid shear stress and atherosclerosis, conserved biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
    • Inflammatory mediator regulation of TRP channels, organism-specific biosystem (from KEGG)
      Inflammatory mediator regulation of TRP channels, organism-specific biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
    • Inflammatory mediator regulation of TRP channels, conserved biosystem (from KEGG)
      Inflammatory mediator regulation of TRP channels, conserved biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
    • Ion channel transport, organism-specific biosystem (from REACTOME)
      Ion channel transport, organism-specific biosystemIon channels mediate the flow of ions across the plasma membrane of cells. They are integral membrane proteins, typically a multimer of proteins, which, when arranged in the membrane, create a pore f...
    • Stimuli-sensing channels, organism-specific biosystem (from REACTOME)
      Stimuli-sensing channels, organism-specific biosystemIon channels that mediate sensations such as pain, warmth, cold, taste pressure and vision. Channels that mediate these sensations include acid-sensing ion channels (ASICs) (Wang & Xu 2011, Qadri et ...
    • TRP channels, organism-specific biosystem (from REACTOME)
      TRP channels, organism-specific biosystemTransient receptor potential (TRP) channel proteins were first discovered in Drosophila melanogaster and have many homologues in other species including humans. TRPs form cationic channels that can ...
    • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
      Transmembrane transport of small molecules, organism-specific biosystem
      Transmembrane transport of small molecules
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    SH2 domain binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    actin filament binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    alpha-tubulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    beta-tubulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    calcium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium channel activity TAS
    Traceable Author Statement
    more info
     
    calmodulin binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cation channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    osmosensor activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase C binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    stretch-activated, cation-selective, calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    actin cytoskeleton reorganization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    actin filament organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    blood vessel endothelial cell delamination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    calcium ion import ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    calcium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    calcium ion transmembrane transport TAS
    Traceable Author Statement
    more info
     
    calcium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium ion transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cartilage development involved in endochondral bone morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell volume homeostasis TAS
    Traceable Author Statement
    more info
    PubMed 
    cell-cell junction assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular calcium ion homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular hypotonic response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular hypotonic response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular hypotonic salinity response IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to heat ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to osmotic stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cortical microtubule organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    diet induced thermogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    hyperosmotic salinity response IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    multicellular organismal water homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of brown fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    osmosensory signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    osmosensory signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of JNK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of chemokine (C-C motif) ligand 5 production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of chemokine (C-X-C motif) ligand 1 production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of energy homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-6 secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of macrophage chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of macrophage inflammatory protein 1 alpha production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of microtubule depolymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of monocyte chemotactic protein-1 production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of vascular permeability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of response to osmotic stress IEA
    Inferred from Electronic Annotation
    more info
     
    response to insulin IEA
    Inferred from Electronic Annotation
    more info
     
    response to mechanical stimulus TAS
    Traceable Author Statement
    more info
    PubMed 
    signal transduction involved in regulation of aerobic respiration IEA
    Inferred from Electronic Annotation
    more info
     
    vasopressin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    adherens junction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cortical actin cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    colocalizes_with cytoplasmic microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    filopodium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    focal adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    growth cone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    integral component of membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    lamellipodium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    ruffle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    transient receptor potential cation channel subfamily V member 4
    Names
    OSM9-like transient receptor potential channel 4
    osm-9-like TRP channel 4
    osmosensitive transient receptor potential channel 4
    transient receptor potential protein 12
    vanilloid receptor-like channel 2
    vanilloid receptor-related osmotically activated channel

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_017090.1 RefSeqGene

      Range
      5001..55321
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_372

    mRNA and Protein(s)

    1. NM_001177428.1NP_001170899.1  transient receptor potential cation channel subfamily V member 4 isoform e

      See identical proteins and their annotated locations for NP_001170899.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a.
      Source sequence(s)
      AB032427, AC007834, DA869138, DQ059644
      Consensus CDS
      CCDS53828.1
      UniProtKB/Swiss-Prot
      Q9HBA0
      Related
      ENSP00000442167.1, OTTHUMP00000240664, ENST00000541794.5, OTTHUMT00000403275
      Conserved Domains (5) summary
      cd00204
      Location:236343
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00520
      Location:511683
      Ion_trans; Ion transport protein
      pfam09685
      Location:502548
      DUF4870; Domain of unknown function (DUF4870)
      pfam12796
      Location:242347
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:191231
      ANK; ANK repeat [structural motif]
    2. NM_001177431.1NP_001170902.1  transient receptor potential cation channel subfamily V member 4 isoform d

      See identical proteins and their annotated locations for NP_001170902.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks a segment in the 5' coding region coding region, compared to variant 1. The encoded isoform (d) is shorter, compared to isoform a.
      Source sequence(s)
      AB032427, AC007834, AF279673, DQ059645
      Consensus CDS
      CCDS53829.1
      UniProtKB/Swiss-Prot
      Q9HBA0
      Related
      ENSP00000444336.1, OTTHUMP00000240665, ENST00000536838.1, OTTHUMT00000403276
      Conserved Domains (5) summary
      cd00204
      Location:204356
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00520
      Location:524696
      Ion_trans; Ion transport protein
      pfam09685
      Location:515561
      DUF4870; Domain of unknown function (DUF4870)
      pfam12796
      Location:255360
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:203234
      ANK; ANK repeat [structural motif]
    3. NM_001177433.1NP_001170904.1  transient receptor potential cation channel subfamily V member 4 isoform c

      See identical proteins and their annotated locations for NP_001170904.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two in-frame exons in the coding region, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a.
      Source sequence(s)
      AB032427, BC143315, DQ059646
      Consensus CDS
      CCDS53827.1
      UniProtKB/Swiss-Prot
      Q9HBA0
      Related
      ENSP00000443611.1, OTTHUMP00000240662, ENST00000544971.5, OTTHUMT00000403273
      Conserved Domains (4) summary
      cd00204
      Location:236336
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      TIGR00870
      Location:149692
      trp; transient-receptor-potential calcium channel protein
      pfam09685
      Location:442488
      DUF4870; Domain of unknown function (DUF4870)
      sd00045
      Location:191231
      ANK; ANK repeat [structural motif]
    4. NM_021625.4NP_067638.3  transient receptor potential cation channel subfamily V member 4 isoform a

      See identical proteins and their annotated locations for NP_067638.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AB032427, AC007834, AJ296305
      Consensus CDS
      CCDS9134.1
      UniProtKB/Swiss-Prot
      Q9HBA0
      Related
      ENSP00000261740.2, OTTHUMP00000240660, ENST00000261740.6, OTTHUMT00000403271
      Conserved Domains (5) summary
      cd00204
      Location:238390
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00520
      Location:558730
      Ion_trans; Ion transport protein
      pfam09685
      Location:549595
      DUF4870; Domain of unknown function (DUF4870)
      pfam12796
      Location:289394
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:237268
      ANK; ANK repeat [structural motif]
    5. NM_147204.2NP_671737.1  transient receptor potential cation channel subfamily V member 4 isoform b

      See identical proteins and their annotated locations for NP_671737.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1, resulting in an isoform (b) that lacks an internal segment compared to isoform a.
      Source sequence(s)
      AB032427, AB073669, AC007834, BC143315
      Consensus CDS
      CCDS9135.1
      UniProtKB/Swiss-Prot
      Q9HBA0
      Related
      ENSP00000442738.1, OTTHUMP00000240663, ENST00000537083.5, OTTHUMT00000403274
      Conserved Domains (4) summary
      cd00204
      Location:238383
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      TIGR00870
      Location:149739
      trp; transient-receptor-potential calcium channel protein
      pfam09685
      Location:489535
      DUF4870; Domain of unknown function (DUF4870)
      sd00045
      Location:237268
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p7 Primary Assembly

      Range
      109783087..109833407 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005253918.1XP_005253975.1  transient receptor potential cation channel subfamily V member 4 isoform X3

      See identical proteins and their annotated locations for XP_005253975.1

      UniProtKB/Swiss-Prot
      Q9HBA0
      Conserved Domains (5) summary
      cd00204
      Location:238390
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00520
      Location:558730
      Ion_trans; Ion transport protein
      pfam09685
      Location:549595
      DUF4870; Domain of unknown function (DUF4870)
      pfam12796
      Location:289394
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:237268
      ANK; ANK repeat [structural motif]
    2. XM_017019774.1XP_016875263.1  transient receptor potential cation channel subfamily V member 4 isoform X3

      UniProtKB/Swiss-Prot
      Q9HBA0
      Conserved Domains (5) summary
      cd00204
      Location:238390
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00520
      Location:558730
      Ion_trans; Ion transport protein
      pfam09685
      Location:549595
      DUF4870; Domain of unknown function (DUF4870)
      pfam12796
      Location:289394
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:237268
      ANK; ANK repeat [structural motif]
    3. XM_011538633.2XP_011536935.2  transient receptor potential cation channel subfamily V member 4 isoform X5

    4. XM_011538631.2XP_011536933.2  transient receptor potential cation channel subfamily V member 4 isoform X2

    5. XM_011538632.2XP_011536934.2  transient receptor potential cation channel subfamily V member 4 isoform X4

    6. XM_011538630.2XP_011536932.2  transient receptor potential cation channel subfamily V member 4 isoform X1

    7. XM_011538634.2XP_011536936.2  transient receptor potential cation channel subfamily V member 4 isoform X6

    8. XM_011538635.2XP_011536937.1  transient receptor potential cation channel subfamily V member 4 isoform X7

      Conserved Domains (4) summary
      cd00204
      Location:289441
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam09685
      Location:600646
      DUF4870; Domain of unknown function (DUF4870)
      pfam12796
      Location:340445
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:288319
      ANK; ANK repeat [structural motif]
    9. XM_011538636.2XP_011536938.1  transient receptor potential cation channel subfamily V member 4 isoform X8

      Related
      ENSP00000437449.1, OTTHUMP00000240661, ENST00000538125.5, OTTHUMT00000403272
      Conserved Domains (3) summary
      cd00204
      Location:289441
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:340445
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:288319
      ANK; ANK repeat [structural motif]

    Alternate CHM1_1.1

    Genomic

    1. NC_018923.2 Alternate CHM1_1.1

      Range
      110188702..110239020 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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