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    FAAH fatty acid amide hydrolase [ Homo sapiens (human) ]

    Gene ID: 2166, updated on 8-Apr-2018
    Official Symbol
    FAAHprovided by HGNC
    Official Full Name
    fatty acid amide hydrolaseprovided by HGNC
    Primary source
    HGNC:HGNC:3553
    See related
    Ensembl:ENSG00000117480 MIM:602935; Vega:OTTHUMG00000007811
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PSAB; FAAH-1
    Summary
    This gene encodes a protein that is responsible for the hydrolysis of a number of primary and secondary fatty acid amides, including the neuromodulatory compounds anandamide and oleamide. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in prostate (RPKM 30.1), thyroid (RPKM 21.8) and 23 other tissues See more
    Orthologs
    Location:
    1p33
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (46394267..46413848)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (46859939..46879520)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ubiquinol-cytochrome c reductase hinge protein Neighboring gene NOP2/Sun RNA methyltransferase family member 4 Neighboring gene fatty acid amide hydrolase pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 1398

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Arachidonic acid metabolism, organism-specific biosystem (from REACTOME)
      Arachidonic acid metabolism, organism-specific biosystemEicosanoids, oxygenated, 20-carbon fatty acids, are autocrine and paracrine signaling molecules that modulate physiological processes including pain, fever, inflammation, blood clot formation, smooth...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • Retrograde endocannabinoid signaling, organism-specific biosystem (from KEGG)
      Retrograde endocannabinoid signaling, organism-specific biosystemEndogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic...
    • Retrograde endocannabinoid signaling, conserved biosystem (from KEGG)
      Retrograde endocannabinoid signaling, conserved biosystemEndogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic...
    • anandamide degradation, organism-specific biosystem (from BIOCYC)
      anandamide degradation, organism-specific biosystemAnandamide, a member of the endocannabinoid class of signaling lipids, is the amide of ethanolamine and arachidonate. It is part of the endocannabinoid system, a neural signaling pathway consisting...
    • anandamide degradation, conserved biosystem (from BIOCYC)
      anandamide degradation, conserved biosystemAnandamide, a member of the endocannabinoid class of signaling lipids, is the amide of ethanolamine and arachidonate. It is part of the endocannabinoid system, a neural signaling pathway consisting...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC102823, MGC138146

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    acylglycerol lipase activity IEA
    Inferred from Electronic Annotation
    more info
     
    amidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    anandamide amidohydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    fatty acid amide hydrolase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fatty acid amide hydrolase activity TAS
    Traceable Author Statement
    more info
     
    oleamide hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    arachidonic acid metabolic process TAS
    Traceable Author Statement
    more info
     
    fatty acid catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    organelle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    fatty-acid amide hydrolase 1
    Names
    anandamide amidohydrolase 1
    oleamide hydrolase 1
    NP_001432.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012195.1 RefSeqGene

      Range
      5001..24582
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001441.2NP_001432.2  fatty-acid amide hydrolase 1

      See identical proteins and their annotated locations for NP_001432.2

      Status: REVIEWED

      Source sequence(s)
      AL050372, BG718115, U82535
      Consensus CDS
      CCDS535.1
      UniProtKB/Swiss-Prot
      O00519
      UniProtKB/TrEMBL
      Q9UG55
      Related
      ENSP00000243167.8, OTTHUMP00000009480, ENST00000243167.8, OTTHUMT00000021443
      Conserved Domains (1) summary
      pfam01425
      Location:95562
      Amidase; Amidase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      46394267..46413848
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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