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    Kitl kit ligand [ Mus musculus (house mouse) ]

    Gene ID: 17311, updated on 10-Oct-2017
    Official Symbol
    Kitlprovided by MGI
    Official Full Name
    kit ligandprovided by MGI
    Primary source
    MGI:MGI:96974
    See related
    Ensembl:ENSMUSG00000019966 Vega:OTTMUSG00000020799
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gb; SF; Sl; Clo; Con; Mgf; SCF; SLF; blz; Kitlg; contrasted
    Orthologs
    Location:
    10 D1; 10 51.4 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (100015635..100100416)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (99478458..99563046)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 35437 Neighboring gene keratin 18 pseudogene Neighboring gene predicted gene, 35533 Neighboring gene THO complex 4 pseudogene

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cytokine activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    stem cell factor receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    ectopic germ cell programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic apoptotic signaling pathway in absence of ligand IDA
    Inferred from Direct Assay
    more info
    PubMed 
    germ cell development TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of mast cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neural crest cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ovarian follicle development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAP kinase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of Ras protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of hematopoietic stem cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of leukocyte migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of mast cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of melanocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of myeloid leukocyte differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    filopodium ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    kit ligand
    Names
    C-kit ligand
    Steel factor
    cloud gray
    grizzle-belly
    hematopoietic growth factor KL
    mast cell growth factor
    stem cell factor
    NP_038626.1
    XP_006513377.1
    XP_006513378.1
    XP_017169312.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347156.1NP_001334085.1  kit ligand isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) has a distinct internal amino acid and is shorter than isoform 1.
      Source sequence(s)
      AC159910, BU700928, U44725
      Consensus CDS
      CCDS83751.1
      UniProtKB/Swiss-Prot
      P20826
    2. NM_013598.3NP_038626.1  kit ligand isoform 1 precursor

      See identical proteins and their annotated locations for NP_038626.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC159910, BU700928, U44725
      Consensus CDS
      CCDS36046.1
      UniProtKB/Swiss-Prot
      P20826
      Related
      ENSMUSP00000100920.1, OTTMUSP00000022753, ENSMUST00000105283.8, OTTMUST00000049195
      Conserved Domains (1) summary
      pfam02404
      Location:1273
      SCF; Stem cell factor

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      100015635..100100416
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313823.1XP_017169312.1  kit ligand isoform X3

      Related
      ENSMUSP00000020129.7, OTTMUSP00000022754, ENSMUST00000020129.7, OTTMUST00000049196
    2. XM_006513315.2XP_006513378.1  kit ligand isoform X2

      Conserved Domains (1) summary
      pfam02404
      Location:46285
      SCF; Stem cell factor
    3. XM_006513314.3XP_006513377.1  kit ligand isoform X1

      Conserved Domains (1) summary
      pfam02404
      Location:46313
      SCF; Stem cell factor
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