Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    Ptgs2 prostaglandin-endoperoxide synthase 2 [ Mus musculus (house mouse) ]

    Gene ID: 19225, updated on 14-Sep-2017
    Official Symbol
    Ptgs2provided by MGI
    Official Full Name
    prostaglandin-endoperoxide synthase 2provided by MGI
    Primary source
    MGI:MGI:97798
    See related
    Ensembl:ENSMUSG00000032487 Vega:OTTMUSG00000049547
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    COX2; Cox-2; PES-2; PHS-2; Pghs2; TIS10; PGHS-2; PHS II; gripghs
    Summary
    This gene encodes an enzyme that is a member of the prostaglandin G/H synthase family. The encoded protein converts arachidonic acid to prostaglandin endoperoxide H2 which is a key enzymatic step in prostaglandin biosynthesis. This gene is the inducible prostaglandin G/H synthase family member that is upregulated during inflammation. Aberrant regulation of this gene is associated with cancer progression in several tissues and an increased risk of cardiovascular events. This gene is the target of many non-steroidal anti-inflammatory drugs. [provided by RefSeq, Sep 2015]
    Orthologs
    Location:
    1 G1; 1 63.84 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (150100031..150108234)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (151947254..151955147)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene heat shock protein 90, alpha (cytosolic), class A member 1 pseudogene Neighboring gene prostaglandin-endoperoxide synthase 2, opposite strand Neighboring gene 40S ribosomal protein S8 pseudogene Neighboring gene prostaglandin-endoperoxide synthase 2, opposite strand 2

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    heme binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ISO
    Inferred from Sequence Orthology
    more info
     
    peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    prostaglandin-endoperoxide synthase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    prostaglandin-endoperoxide synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    anagen IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    bone mineralization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    brown fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to fluid shear stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to non-ionic osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cyclooxygenase pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cyclooxygenase pathway ISO
    Inferred from Sequence Orthology
    more info
     
    decidualization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    decidualization ISO
    Inferred from Sequence Orthology
    more info
     
    embryo implantation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryo implantation ISO
    Inferred from Sequence Orthology
    more info
     
    fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    keratinocyte differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    learning ISO
    Inferred from Sequence Orthology
    more info
     
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    maintenance of permeability of blood-brain barrier ISO
    Inferred from Sequence Orthology
    more info
     
    memory ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of blood vessel diameter ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of synaptic transmission, dopaminergic ISO
    Inferred from Sequence Orthology
    more info
     
    ovulation ISO
    Inferred from Sequence Orthology
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of NF-kappaB import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of brown fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fever generation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of fever generation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fibroblast growth factor production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of platelet-derived growth factor production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of prostaglandin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of synaptic transmission, glutamatergic ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transforming growth factor beta production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vascular endothelial growth factor production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
     
    prostaglandin biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    prostaglandin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    prostaglandin metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to cytokine ISO
    Inferred from Sequence Orthology
    more info
     
    response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    colocalizes_with caveola ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    NOT nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    prostaglandin G/H synthase 2
    Names
    PGH synthase 2
    cyclooxygenase-2
    glucocorticoid-regulated inflammatory cyclooxygenase
    macrophage activation-associated marker protein P71/73
    prostaglandin H2 synthase 2
    NP_035328.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011198.4NP_035328.2  prostaglandin G/H synthase 2 precursor

      See identical proteins and their annotated locations for NP_035328.2

      Status: REVIEWED

      Source sequence(s)
      AC114655, AK049923, AK149820, BY033144, CD547477
      Consensus CDS
      CCDS15353.1
      UniProtKB/Swiss-Prot
      Q05769
      Related
      ENSMUSP00000035065.7, OTTMUSP00000068320, ENSMUST00000035065.8, OTTMUST00000126288
      Conserved Domains (2) summary
      cd09816
      Location:75562
      prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
      pfam00008
      Location:2153
      EGF; EGF-like domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      150100031..150108234
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center